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LC3-mHTT-IN-AN1

Catalog No. T8081   CAS 486443-73-6

LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound that interacts with both mutant huntingtin protein (mHTT) and LC3B. LC3-mHTT-IN-AN1 targeted mHTT to autophagosomes reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
LC3-mHTT-IN-AN1 Chemical Structure
LC3-mHTT-IN-AN1, CAS 486443-73-6
Pack Size Availability Price/USD Quantity
1 mg In stock $ 119.00
2 mg In stock $ 168.00
5 mg In stock $ 255.00
10 mg In stock $ 378.00
25 mg In stock $ 639.00
50 mg In stock $ 913.00
100 mg In stock $ 1,230.00
1 mL * 10 mM (in DMSO) In stock $ 279.00
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Purity: 97.26%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound that interacts with both mutant huntingtin protein (mHTT) and LC3B. LC3-mHTT-IN-AN1 targeted mHTT to autophagosomes reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons.
In vitro LC3-mHTT-IN-AN1 targeted mHTT to autophagosomes, reduced mHTT levels in an allele-selective manner, and rescued disease-relevant phenotypes in cells and in vivo in fly and mouse models of Huntington's disease.
Molecular Weight 411.04
Formula C15H9Br2NO3
CAS No. 486443-73-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 120 mg/ml(291.94 mM), sonification is recommended.

TargetMolReferences and Literature

1. Li Z, et al. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019 Nov;575(7781):203-209.

Related compound libraries

This product is contained In the following compound libraries:
Autophagy Compound Library Bioactive Compound Library Bioactive Compounds Library Max

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LC3-mHTT-IN-AN2

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Keywords

LC3-mHTT-IN-AN1 486443-73-6 Autophagy Others PROTAC ATTECs Autophagosome-tethering compounds LC3mHTTINAN1 LC3 mHTT IN AN1 Inhibitor LC-3-mHTT-IN-AN1 inhibit inhibitor

 

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