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Search Results for " hmt "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T6364	Desfesoterodine	5-HMT,(R)-5-Hydroxymethyl Tolterodine,PNU-200577,5-HM,5-hydroxymethyl Tolterodine	AChR
	Desfesoterodine (5-HMT) is a new muscarinic receptor antagonist with Kb of 0.84 nM.		AChR
T8548	Metoprine		Histone Methyltransferase , Antifolate , Histamine Receptor
	Metoprine is a potent inhibitor of histamine N-methyltransferase (HMT), with potential antineoplastic activity.		Histone Methyltransferase , Antifolate , Histamine Receptor
T9419	Fesoterodine	(R) Fesoterodine	AChR
	Fesoterodine ((R) Fesoterodine) is an orally active, competitive mAChR antagonist with pKi values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. It is used for the overactive bladder (OAB).		AChR
T1475	Fesoterodine fumarate	Toviaz,SPM 907	AChR
	Fesoterodine fumarate (Toviaz) is the fumarate salt form of fesoterodine, a competitive muscarinic receptor antagonist with muscle relaxant and urinary antispasmodic properties. Fesoterodine is rapidly hydrolyzed in vivo...		AChR
T62512	IHMT-MST1-58		Hippo pathway
	IHMT-MST1-58 is a STE20-like protein 1 kinase (MST1) inhibitor (IC50:23 nM) with high efficiency, selectivity and oral activity. IHMT-MST1-58 can be used to study type 1 or type 2 diabetes.		Hippo pathway
T12902	SHMT-IN-1		Others
	SHMT-IN-1 is a potent plasmodial serine hydroxymethyltransferase (SHMT) inhibitor with antitumor activity.		Others
T60196	IHMT-PI3Kδ-372 S-isomer		PI3K
	IHMT-PI3Kδ-372 S-isomer is a potent and selective PI3Kδ inhibitor with an IC50 of 14 nM. IHMT-PI3Kδ-372 S-isomer shows high selectivity over other class I PI3Ks (56∼83 fold) and other protein kinases. IHMT-PI3Kδ-372 can ...		PI3K
T62404	SHMT-IN-2		Others
	SHMT-IN-2 (compound 2) is a specific human SHMT1/2 small molecule inhibitor that acts on SHMT1 (IC50: 13 nM) and SHMT2 (IC50: 66 nM). SHMT-IN-2 inhibits the growth of many human cancer cells and is sensitive to B-cell ly...		Others
T35530	IHMT-PI3Kδ-372	IHMT-PI3Kδ-372	PI3K
	IHMT-PI3Kδ-372 is a selective inhibitor of PI3Kδ with an IC50 of 14 nM and can be used in studies about chronic obstructive pulmonary disease.		PI3K
T11167	EHMT2-IN-2		Others
	EHMT2-IN-2 Used in the research of blood disease or cancer. EHMT2-IN-2 is a potent EHMT inhibitor, with IC50s of all <100 nM for EHMT1 peptide, EHMT2 peptide and cellular EHMT2.		Others
T11166	EHMT2-IN-1		Others
	EHMT2-IN-1 is a potent EHMT inhibitor, . Used in the research of blood disorder or cancer.with IC50s of all <100 nM for EHMT1 peptide, EHMT2 peptide and cellular EHMT2.		Others
TP1460	NH2-KLGADTDGEQDQHMTYGGQ-COOH
	NH2-QGGYTMHQDQEGDTDAGLK-COOH is a synthetic peptide chain consisting of a primary amine group attached to lysine and a carboxyl group attached to glutamine.
T79780	IHMT-EZH2-426		Histone Methyltransferase
	IHMT-EZH2-426 (compound 38) is a potent, covalent degrader of EZH2, demonstrating IC50 values of 1.3 nM for EZH2 wild-type, 1.2 nM for EZH2-A687V, and 1.7-3.5 nM for EZH2-Y641F/Y641N/Y641S mutants. The compound effective...		Histone Methyltransferase
T78836	IHMT-PI3K-455		PI3K
	IHMT-PI3K-455 (Compound 15u) is a potent, selective PI3Kγ/δ dual inhibitor, demonstrating oral activity, with IC50 values of 7.1 nM for PI3Kγ and 0.57 nM for PI3Kδ. This compound inhibits AKT phosphorylation and promotes...		PI3K
T78758	IHMT-IDH1-053		Isocitrate Dehydrogenase (IDH)
	IHMT-IDH1-053 (compound 16) is an irreversible inhibitor exhibiting high selectivity for the IDH1 R132H mutant, achieving an IC50 of 4.7 nM. It preferentially targets IDH1 mutants over wild-type IDH1 and IDH2, both wild-...		Isocitrate Dehydrogenase (IDH)
T63076	IHMT-TRK-284
	IHMT-TRK-284 (Compound 34) is a potent, orally active type II TRK kinase inhibitor that acts on TRKA (IC50: 10.5 nM), TRKB (IC50: 0.7 nM), and TRKC (IC50: 2.6 nM). IHMT-TRK-284 exhibits good selectivity in the kinase gro...
T8768	MM-102 TFA	HMTase Inhibitor IX TFA	Histone Methyltransferase
	MM-102 TFA (HMTase Inhibitor IX TFA) is a potent WDR5/MLL interaction inhibitor, achieves IC50 = 2.4 nM. MM-102 compound prevents the interaction between mixed lineage leukemia 1 (MLL1) and WD Trp-Asp repeat domain 5 (WD...		Histone Methyltransferase
T67947	WDR5-0102		Histone Methyltransferase
	WDR5-0102 is a compound that inhibits the WDR5-MLL1 interface (K dis = 7 μM, K d = 4 μM), selectively reducing MLL1 HMT activity without affecting the human H3K4 methyltransferase SETD7 or other HMTs, including G9a, EHMT...		Histone Methyltransferase
T2352	AMI-1		Histone Methyltransferase
	AMI-1 is an effective and selective Histone Methyltransferase (HMT) inhibitor (IC50: 3.0/8.8 μM, for yeast Hmt1p, and human PRMT1).		Histone Methyltransferase
T13334	WDR5-IN-1		Others
	WDR5-IN-1 is a potent and selective inhibitor of WD repeat domain 5 (WDR5) (Kd <0.02 nM), and also inhibits MLL1 histone methyltransferase (HMT) activity (IC50: 2.2 nM).		Others
T38784	Histone H3 (1-25), amide	Histone H3 (1-25), amide
	Histone H3 (1-25), amide is a N-terminal peptide fragment of histone H3 that serves as a substrate for histone methyltransferases (HMTs). It can be utilized to identify the substrate for HMTs. Compared to histone H3 (15-...
T12091	MM-589		JAK
	MM-589 is a potent WD repeat domain 5 (WDR5) inhibitor and mixed lineage leukemia (MLL) protein-protein interaction.		JAK
T12091L	MM-589 TFA		JAK
	MM-589 TFA is a potent WD repeat domain 5 (WDR5)inhibitor and mixed lineage leukemia (MLL) protein-protein interaction.		JAK

Compounds

Desfesoterodine

T6364

Synonym: 5-HMT,(R)-5-Hydroxymethyl Tolterodine,PNU-200577,5-HM,5-hydroxymethyl Tolterodine

Target: Histone Methyltransferase, Antifolate, Histamine Receptor

Fesoterodine

T9419

Synonym: (R) Fesoterodine

Target: AChR

Fesoterodine fumarate

T1475

Synonym: Toviaz,SPM 907

Target: Hippo pathway

IHMT-PI3Kδ-372 S-isomer

Synonym: IHMT-PI3Kδ-372

NH2-KLGADTDGEQDQHMTYGGQ-COOH

Target: Histone Methyltransferase

Target: Isocitrate Dehydrogenase (IDH)

Synonym: HMTase Inhibitor IX TFA

Target: Histone Methyltransferase

WDR5-0102

T67947

Synonym:

Target: Histone Methyltransferase

AMI-1

T2352

Synonym:

Target: Histone Methyltransferase

Histone H3 (1-25), amide

T38784

Synonym: Histone H3 (1-25), amide

Cat No.	Product Name	Synonyms	Targets
T6803	Chaetocin		Histone Methyltransferase , Antibacterial , Antibiotic
	Chaetocin, a natural product from Chaetomium species, is a histone methyltransferase inhibitor with IC50 of 0.8 μM, 2.5 μM and 3 μM for dSU(VAR)3-9, mouse G9a and Neurospora crassa DIM5, respectively.		Histone Methyltransferase , Antibacterial , Antibiotic

Natural Products

Chaetocin

T6803

Synonym:

Target: Histone Methyltransferase, Antibacterial, Antibiotic

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-02340	HNMT Protein, Human, Recombinant (GST)	Human	E. coli
	HNMT (Histamine N-methyltransferase) is a Protein Coding gene. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. HNMT, the major enzyme for the metabol...
TMPY-02386	PTP4A2 Protein, Human, Recombinant (GST)	Human	E. coli
	PRL-2 (Protein-tyrosine phosphatase of regenerating liver 2), also known as PTP4A2 (Protein tyrosine phosphatase type IVA, member 2), is a member of PTP family and has an important function in controlling cell growth. PR...
TMPJ-00484	SHMT1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Serine Hydroxymethyltransferase Cytosolic (SHMT1) is a member of the SHMT family. SHMT1 is a cytoplasmic protein and exists as a homotetramer. SHMT1 catalyzes the reversible conversion of serine and tetrahydrofolate to g...
TMPK-01532	HLA-A02:01&B2M&P53 R175H (HMT*EVVRHC) Monomer Protein, Human, MHC (His & Avi)	Human	HEK293 Cells
	p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell prolifer...
TMPK-01552	HLA-A02:01&B2M&P53 R175H (HMT*EVVRHC) Monomer Protein, Human, MHC (His & Avi), Biotinylated	Human	HEK293 Cells
	p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell prolifer...
TMPK-01508	HLA-A02:01&B2M&P53 WT (HMT*EVVRRC) Tetramer Protein, Human, MHC (His & Avi)	Human	HEK293 Cells
	p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell prolifer...
TMPK-01437	HLA-A02:01&B2M&P53 R175H (HMT*EVVRHC) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled	Human	HEK293 Cells
	p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell prolifer...
TMPK-01531	HLA-A02:01&B2M&P53 R175H (HMT*EVVRHC) Tetramer Protein, Human, MHC (His & Avi)	Human	HEK293 Cells
	p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell prolifer...
TMPK-01442	HLA-A02:01&B2M&P53 WT (HMT*EVVRRC) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled	Human	HEK293 Cells
	p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell prolifer...
TMPK-01538	HLA-A02:01&B2M&P53 WT (HMT*EVVRRC) Monomer Protein, Human, MHC (His & Avi), Biotinylated	Human	HEK293 Cells
	p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell prolifer...
TMPK-01509	HLA-A02:01&B2M&P53 WT (HMT*EVVRRC) Monomer Protein, Human, MHC (His & Avi)	Human	HEK293 Cells
	p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell prolifer...
TMPH-02105	ASH2L Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Transcriptional regulator. Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters. Component of the Set1/Ash2 ...