gaba-in-2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T82355	GABA-IN-2
	GABA-IN-2 (Compound 5), a GABA inhibitor, exhibits both larvicidal and insecticidal properties, achieving an 87% mortality rate at a concentration of 50 mg/L [1].
T12930	SKF89976A hydrochloride	d,l-SKF89976A hydrochloride	GABA Receptor
	SKF89976A hydrochloride (d,l-SKF89976A hydrochloride) is a selective inhibitor GABA transporter such as GAT-1 (IC50s = 0.28 μM), GAT-2 (IC50s = 137.34 μM) and GAT-3(IC50s = 202.8 μM) in CHO cells.		GABA Receptor
TN1217	2'-O-Methylisoliquiritigenin		Dopamine Receptor , 5-HT Receptor , GABA Receptor
	2'-O-Methylisoliquiritigenin, a compound synthesized by enzymes specifically induced in NR.2'-O-Methylisoliquiritigenin, isolated from the Arachis species, up-regulates 5-HT, NE, DA and GABA pathways, but does not put a ...		Dopamine Receptor , 5-HT Receptor , GABA Receptor
T16811	RWJ-51204		GABA Receptor
	RWJ-51204 is a selective adenosine A2A receptor antagonist and a partial agonist of GABA(A) receptor (IC50: 0.2-2 nM). It has neuroprotective and movement-improving effects and can be used in research related to Parkinso...		GABA Receptor
T2196	Fipronil	Fluocyanobenpyrazole,Termidor	P450 , GluCls , GABA Receptor
	Fipronil (Fluocyanobenpyrazole) is a broad-use insecticide that belongs to the phenylpyrazole chemical family. Fipronil is a broad-spectrum insecticide that disrupts the insect central nervous system by blocking GABA-gat...		P450 , GluCls , GABA Receptor
TN1308	6-Hydroxyflavanone		Others , Lipoxygenase , COX , GABA Receptor
	6-Hydroxyflavanone, extracted from the leaves of Acorus calamus, exhibits anti-inflammatory and anti-neuropathic pain activity by targeting cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX), as well as opioid and GABA-A r...		Others , Lipoxygenase , COX , GABA Receptor
TP1570	Cortistatin-14		Somatostatin
	Cortistatin-14, a neuropeptide structurally similar to growth inhibitor-14, has anticonvulsant and neuroprotective effects and impairs recognition memory consolidation in mice through activation of sst(2), growth hormone...		Somatostatin
T4814	(R)-5-Oxopyrrolidine-2-carboxylic acid	D-Pyroglutamic acid,(R)-(+)-2-Pyrrolidone-5-carboxylic acid	Others , Endogenous Metabolite
	(R)-5-Oxopyrrolidine-2-carboxylic acid (D-Pyroglutamic acid) is a cyclic derivative of glutamic acid, physiologically present in mammalian tissues. It has been shown that PCA releases GABA from the cerebral cortex and di...		Others , Endogenous Metabolite
T37190	L-Allylglycine		Dehydrogenase , GABA Receptor
	L-Allylglycine is an amino acid derivative that reduces glutamate decarboxylase (GAD) activity by 60% when administered at a dose of 39.8 μmol/g per hour ex vivo in mouse brain preparations. L-Allylglycine (1.2 mmol/kg, ...		Dehydrogenase , GABA Receptor
T0169	Nefiracetam	DM9384,DZL-221	GABA Receptor
	Nefiracetam (DM9384) are underway in Phase 2 trials. Nefiracetam, a GABAergic、 cholinergic、and monoaminergic neuronal system enhancer, is used for Ro 5-4864-induced convulsions.		GABA Receptor
T36520	COR659		Cannabinoid Receptor , GABA Receptor
	COR659 is a GABAB positive allosteric modulator (PAM) . COR659 suppresses alcohol and chocolate self-administration in rats[1]. COR659 apparently exerts its effects via a composite mechanism, including positive allosteri...		Cannabinoid Receptor , GABA Receptor
T5089	5-Aminovaleric acid		Others , Endogenous Metabolite
	5-aminovalerate (or 5-aminopentanoic acid) is a lysine degradation product. It can be produced both endogenously or through bacterial catabolism of lysine. 5-aminovalerate is formed via the following multi-step reaction:...		Others , Endogenous Metabolite
T3S2259	Methyl eugenol	4-allylveratrole,eugenyl methyl ether,O-methyleugenol,Eugenol Methyl ether	GABA Receptor
	1. Methyl eugenol (4-allylveratrole) is a natural constituent of the essential oils of a number of plants widely used in foodstuffs as flavouring agents, in view of the carcinogenic potential of ME, the need to check its...		GABA Receptor
TP2309	Neurotensin TFA	NEUROTENSIN TFA,Neurotensin TFA (39379-15-2 free base)	Others
	Neurotensin TFA (39379-15-2 free base) is an endogenous 13 amino acid neuropeptide with profound opioid-independent analgesic effects. It behaves as a neurotransmitter in the brain, as a hormone in the gut, and also as a...		Others
T38192	Unifiram		Others
	Unifiram is a nootropic agent.1It increases acetylcholine (ACh) release in the rat cerebral cortexin vivoand induces a long-lasting increase in the amplitude of field excitatory postsynaptic potentials (fEPSPs) in the ra...		Others
T28346	PD-217014 HCl	PD 217014,PD217014,PD-217,014,PD-217014
	PD-217014 is a GABA analog. It inhibits (3)H-gabapentin binding to alpha(2)delta subunit of voltage-gated calcium channels in a concentration-dependent manner (K(i) = 18 nmol/l). PD-217014 possesses visceral analgesic ac...
T70414	NNC-711
	NNC-711 is a potent and selective inhibitor of GABA uptake by GAT-1 (IC50 values are 0.04, 171, 1700 and 622 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively). NNC-711 is anticonvulsant following systemic administra...
T61625	GABAA receptor agonist 2
	GABAA receptor agonist 2 (compound 4c) is a highly potent GABAA receptor agonist which exhibits anti-depressive properties in classical mouse models of depression, such as the FST and TST. By binding to the GABA binding ...
T73818	Homocarnosine TFA
	Homocarnosine TFA, a unique dipeptide of γ-aminobutyric acid (GABA) and histidine found in the brain, acts as an inhibitory neuromodulator synthesized from GABA within neurons. It exhibits anticonvulsant effects [1], and...
T37201	CAY10787
	CAY10787 is an oxysterol and a negative allosteric modulator of GABAAreceptors.1,2It reduces GABA-induced currents in HEK cells expressing α1β1γ2or α4β3γ2subunit-containing GABAAreceptors (IC50s = 1.5 and 1 μM, respectiv...