19
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T2144 | Tacrolimus | Fujimycin,FK506,FR900506 | Phosphatase , Others , Antibacterial , Antibiotic , mTOR , Autophagy |
Tacrolimus (Fujimycin) can bind FKBP12 to form a high-affinity complex (Ki: 0.2 nM) which inhibits the activity of the calcium/calmodulin-dependent protein phosphatase. | |||
T14298 | Rimiducid | Apoptosis , Others , Fatty Acid Synthase | |
Rimiducid is a lipid-permeable tacrolimus analogue, homodimerizing an analogue of human protein fkbp12 and binding to wild-type fkbp12 with 1000-fold lower affinity. Rimiducid is a dimerizer agent that acts by cross-link... | |||
T20879 | Tacrolimus monohydrate | FK-506,FR 900506,Prograf,FR900506,Tacrolimus hydrate,LCP-Tacro,FK 506 | Phosphatase , Others , Antibacterial , Antibiotic , Autophagy |
Tacrolimus monohydrate (LCP-Tacro) is a macrolide from the culture broth of a strain of Streptomyces tsukubaensis, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, whi... | |||
T14299 | AP20187 | B/B Homodimerizer | Others |
AP20187 (B/B Homodimerizer) is a cell-permeable compound employed to dimerize FK506-binding protein (FKBP) fusion proteins, thereby initiating biological signaling cascades, gene expression, or disrupting protein-protein... | |||
T13884 | Shield-1 | Others | |
Shield-1 is a specific, high-affinity and cell-permeant ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused protein... | |||
T1784 | Everolimus | RAD001,SDZ-RAD | Apoptosis , Others , mTOR , Autophagy |
Everolimus (SDZ-RAD) is a potent mTOR inhibitor that binds to FKBP-12. It is used alone or in combination with calcineurin inhibitors. | |||
T11451 | GPI-1046 | Others , HIV Protease | |
GPI-1046 is an immunophilin ligand without antibiotic action and attenuates ethanol intake in part through the upregulation of glutamate transporter 1 (GLT1) in PFC and NAc-core. | |||
T2481 | Ascomycin | FK520,Immunomycin,FR-900520 | Phosphatase , Others , Antibiotic , Parasite , Antifungal |
Ascomycin (Immunomycin)(Immunomycin, FR-900520, FK520) is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties. | |||
T1537 | Rapamycin | Sirolimus,AY 22989,NSC-2260804 | Others , Endogenous Metabolite , Antibiotic , mTOR , Autophagy , Antifungal |
Rapamycin (AY 22989) is a natural product of macrolides, an mTOR inhibitor with specificity (HEK293 cells: IC50=0.1 nM). Rapamycin has immunosuppressive activity and induces autophagy. | |||
T2567 | Etonogestrel | 3-Oxodesogestrel,3-keto-Desogestrel,Nexplanon,Implanon | Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Progesterone Receptor , Endogenous Metabolite |
Etonogestrel (Implanon) is a steroidal progestin used as hormonal contraceptives. | |||
T16836 | SAFit2 | FKBP | |
SAFit2 is a highly effective and selective fk506 binding protein 51(FKBP51) inhibitor (Ki: 6 nM). SAFit2 can enhance AKT2-AS160 binding and participate in the downstream response of glucocorticoid release in vivo, and is... | |||
T16835 | SAFit1 | Others | |
SAFit1 is an inhibitor of FK506 binding protein 51 (FKBP51)-specific (Ki: 4±0.3 nM). | |||
T71771 | Supradamal | ||
Supradamal is a potent Inhibitor of Plasmodium FK506 Binding Protein 35 (FKBD35). It also acts as an HIV inhibitor. | |||
T80779 | WDB002 | ||
WDB002, a natural product belonging to the FK506/rapamycin family, targets CEP250 and may be employed in COVID-19 research [1]. | |||
T28790 | SKF1 | ||
SKF1 is a suppressor of the ability of FK506. SKF1 inhibits cell growth in the presence of high levels of NaCl, induces cell death in low salt conditions, interacts directly with yeast mitochodria. | |||
T13888 | SLF | Others | |
SLF is a synthetic ligand for FK506-binding protein (FKBP)( with an affinity of 3.1 μM for FKBP51 and an IC50 of 0.22 μM for FKBP12). SLF can be used in the synthesis of PROTAC. | |||
T36110 | L-Pyrohomoglutamic Acid | ||
L-Pyrohomoglutamic acid is an amino acid building block.1,2It has been used in the synthesis of ligands for FK506-binding proteins (FKBPs) and histone deacetylase (HDAC) inhibitors. 1.Pomplun, S., Wang, Y., Kirschner, A.... | |||
T73817 | SLF TFA | ||
SLF TFA, a synthetic ligand for FK506-binding protein (FKBP), exhibits affinity toward FKBP51 with a value of 3.1 μM and demonstrates an IC50 of 2.6 μM for FKBP12. This compound is utilized in the synthesis of PROTAC [1]... | |||
TP2079 | AD 01 | ||
FKBPL (FK506-binding protein like)-based peptide. Binds to and upregulates expression of CD44. Inhibits breast cancer stem cell (BCSC) growth. Decreases pluripotency markers and promotes differentiation of BCSCs. Also in... |