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SAFit2

Name: SAFit2
Brand: TargetMol
SKU: T16836
Price: 80 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T16836Cas No. 1643125-33-0

SAFit2 is a highly potent and selective inhibitor of fk506 binding protein 51 (FKBP51) with a Ki value of 6 nM. SAFit2 can enhance the binding of AKT2-AS160 and participate in the downstream response of glucocorticoid release in vivo. It is a candidate compound for the treatment of obesity, chronic pain, depression and anxiety.

SAFit2

🥰Excellent

Purity: 99.96%

Catalog No. T16836Cas No. 1643125-33-0

Pack Size	Price	Availability
1 mg	$80	In Stock
5 mg	$197	In Stock
10 mg	$296	In Stock
25 mg	$503	In Stock
50 mg	$717	In Stock
100 mg	$938	In Stock
1 mL x 10 mM (in DMSO)	$261	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.96%

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COA

Product Introduction

Bioactivity

Description	SAFit2 is a highly potent and selective inhibitor of fk506 binding protein 51 (FKBP51) with a Ki value of 6 nM. SAFit2 can enhance the binding of AKT2-AS160 and participate in the downstream response of glucocorticoid release in vivo. It is a candidate compound for the treatment of obesity, chronic pain, depression and anxiety.
Targets&IC50	FKBP51:6 nM(ki)
In vitro	METHODS: The effects of SAFit2 (1, 5, 10 μM) on macrophage migration were evaluated in a Transwell assay. RESULTS SAFit2 significantly reduced macrophage migration in a concentration-dependent manner. [4]
In vivo	METHODS: SAFit2 (20 mg/kg, intraperitoneal injection, twice a day, 10 days) was administered to mice and glucose tolerance was observed. RESULTS SAFit2 treatment significantly improved glucose tolerance. [1]

Chemical Properties

Molecular Weight	802.99
Formula	C₄₆H₆₂N₂O₁₀
Cas No.	1643125-33-0
Smiles	COc1ccc(CC[C@@H](OC(=O)[C@@H]2CCCCN2C(=O)[C@@H](C2CCCCC2)c2cc(OC)c(OC)c(OC)c2)c2cccc(OCCN3CCOCC3)c2)cc1OC
Relative Density.	1.168 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90.0 mg/mL (112.1 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (4.11 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2453 mL	6.2267 mL	12.4535 mL	62.2673 mL
5 mM	0.2491 mL	1.2453 mL	2.4907 mL	12.4535 mL
10 mM	0.1245 mL	0.6227 mL	1.2453 mL	6.2267 mL
20 mM	0.0623 mL	0.3113 mL	0.6227 mL	3.1134 mL
50 mM	0.0249 mL	0.1245 mL	0.2491 mL	1.2453 mL
100 mM	0.0125 mL	0.0623 mL	0.1245 mL	0.6227 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc