errα — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T11230	ERRα antagonist-1	ERR+/- antagonist-1,ERRa antagonist-1	Estrogen/progestogen Receptor
	ERRα antagonist-1 (ERR+/- antagonist-1) is a high-affinity, selective antagonist of the estrogen-related receptor α (ERRα). It effectively prevents the interaction of ERRα with both Proliferator-activated Receptor γ Coac...		Estrogen/progestogen Receptor
T5835	PROTAC ERRα ligand 2		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	PROTAC ERRα ligand 2 is an estrogen-related receptor α (ERRα) inverse agonist( IC50 : 5.67 nM)		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
T15191	PROTAC ERRα ligand 1		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	PROTAC ERRα ligand 1 is an α (ERRα) antagonist of estrogen-related receptor (IC50s of 0.04 and 2.8 μM for ERRα and ERRγ, respectively).		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
T39837	PROTAC ERRα Degrader-3
	PROTAC ERRα Degrader-3 is a highly effective and selective von Hippel-Lindau-based ligand that efficiently degrades the ERRα protein. At a concentration of 30 nM, this compound exhibits a remarkable degradation capabilit...
T18609	PROTAC ERRα Degrader-2		Others
	PROTAC ERRα Degrader-2 is a compound consisting of an MDM2 ligand binding group, a linker, and an estrogen-related receptor alpha (ERRα) binding group. This compound is designed to specifically degrade estrogen-related r...		Others
T17941	ERRα Ligand-Linker Conjugates 1		Others
	ERRα Ligand-Linker Conjugates 1 refers to a chemical compound that consists of a ligand targeting estrogen-related receptor alpha (ERRα), and a PROTAC linker that facilitates the recruitment of E3 ligases MDM2. It finds ...		Others
T18651	(rel)-PROTAC ERRα Degrader-1		Others
	(rel)-PROTAC ERRα Degrader-1 is a relative configuration of PROTAC ERRα Degrader-1, which is an estrogen-related receptor alpha (ERRa) degrader. PROTAC ERRα Degrader-1 consists of an MDM2 ligand binding moiety, a linker ...		Others
T61923	ERRα antagonist-2
	ERRα antagonist-2 (Compound 11) is a potential Reverse agonist of ERR α (estrogen receptor related receptor α) (IC50=0.80 μ M). ERRα antagonist-2 can inhibit the migration and invasion of ER-negative MDA-MB-231 cells. ER...
T0760	Cholesterol	Cholesterin,Cholesteryl alcohol	Estrogen Receptor/ERR , MRP , Endogenous Metabolite , ROR
	Cholesterol (cholesteryl alcohol) is a natural product that is the major sterol in mammals and an agonist of estrogen-related receptor α (ERRα). Cholesterol is widely found in the cell membranes of animals and is also us...		Estrogen Receptor/ERR , MRP , Endogenous Metabolite , ROR
T74559	PROTAC_ERRα
	PROTAC_ERRα is a potent, selective degrader of ERRα, efficiently facilitating its proteasomal degradation. This compound specifically targets ERRα protein, achieving a degradation efficiency of over 80% [1].
T0593	XCT790		Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Autophagy
	XCT790 is a potent, selective and inverse agonist of estrogen-related receptor alpha(ERRα).
T2177	Kaempferol	Kempferol,Robigenin	Apoptosis , Estrogen Receptor/ERR , Mitophagy , Estrogen/progestogen Receptor , HIV Protease , Endogenous Metabolite , Parasite , Autophagy
	Kaempferol (Robigenin) is a natural flavonoid and an inverse agonist of ERRα and ERRγ. Kaempferol has a wide range of antitumor, anti-inflammatory, antioxidant, antibacterial and antiviral activities.
T77552	SLU-PP-1072		Apoptosis , Estrogen/progestogen Receptor
	SLU-PP-1072 is an ERRα and ERRγ inverse dual agonist that disrupts PCa cell metabolism and induces apoptosis through cell cycle dysregulation.SLU-PP-1072 is used to study prostate cancer (PCa).		Apoptosis , Estrogen/progestogen Receptor
T77577	SLU-PP-332		Estrogen/progestogen Receptor
	SLU-PP-332 is a pan-estrogen receptor-related receptor (ERR) agonist with high affinity for ERRα, ERRβ, and ERRγ with EC50 values of 98, 230, and 430 nM, respectively.SLUPP-332 enhances mitochondrial function and cellula...		Estrogen/progestogen Receptor
T2250	DY131	DY 131,GSK 9089,DY-131	Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Smo
	DY131 (DY-131) is a novel selective agonist of ERRβ and ERRγ.		Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Smo
T8370	GSK5182		Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Reactive Oxygen Species
	GSK5182 is a highly selective inverse estrogen-related receptor γ agonist (IC50 : 79 nM)
T60441	DK3
	DK3 is a potent and selective agonist of estrogen-related receptor alpha (ERRα). ERRα is a potential drug target for cancer and metabolic diseases [1].
T40349	DS45500853
	DS45500853, an estrogen-related receptor α (ERRα) agonist, acts as an inhibitor of the binding interaction between receptor-interacting protein 140 (RIP140) corepressor peptide (10 nM) and GST-ERRα ligand-binding domain ...
T73152	SLU-PP-915
	SLU-PP-915 is an agonist for Estrogen Related Receptors (ERR), exhibiting an EC50 value of roughly 400 nM across ERRα, ERRβ, and ERRγ. This compound shows promise for applications in enhancing oxidative metabolism and ma...
T39838	(S,R,S)-AHPC-C7-amine	VH032-C7-amine,(S,R,S)-AHPC-C7-amine
	(S,R,S)-AHPC-C7-amine, also known as VH032-C7-amine, is a chemically synthesized conjugate that functions as an E3 ligase ligand-linker. This compound combines the VH032-based VHL ligand with a specific linker designed f...