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Cholesterol

Catalog No. T0760 CAS 57-88-5

Synonyms: Cholesterin, Cholesteryl alcohol

Cholesterol (cholesteryl alcohol) is a natural product that is the major sterol in mammals and an agonist of estrogen-related receptor α (ERRα). Cholesterol is widely found in the cell membranes of animals and is also used in the synthesis of several important hormones and bile acids.

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Cholesterol, CAS 57-88-5

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500 mg	In stock	$ 45.00

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Purity: 99.94%

Purity: 99.74%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Cholesterol (cholesteryl alcohol) is a natural product that is the major sterol in mammals and an agonist of estrogen-related receptor α (ERRα). Cholesterol is widely found in the cell membranes of animals and is also used in the synthesis of several important hormones and bile acids.
In vitro	METHODS: CD4+ T lymphocytes were incubated with 7-KC (17.5-70 µM) and Cholesterol-MβCD (17.5-70 µM) for 10 min, and T cell membrane order and disorder were assessed using di-4 ANEPPDHQ fluorescent dye. RESULTS: After exposure to 7-KC, T cell membrane order was altered in a dose-dependent manner, with significant reconstitution of membrane order observed only in cells treated with 35 µM Cholesterol, while reconstitution with l7.5 µM Cholesterol induced minimal effects. [1] METHODS: Human gastric cancer cells SNU601, SNU638 and SNU216 were treated with Cholesterol (25-100 µM) for 48 h and cell viability was measured using MTT Assay. RESULTS: Cholesterol caused a dose-dependent decrease in cell viability in all three cell lines. [2]
In vivo	METHODS: To induce hypercholesterolemia, STD:ddY mice were fed a high cholesterol diet (1% cholesterol, 0.5% cholic acid, 0.5% olive oil and 93% standard mouse chow). RESULTS: Cholesterol can be used to construct a mouse model of hypercholesterolemia. [3] METHODS: To induce hyperlipidemia, CD-1 mice were fed a high cholesterol diet (2% cholesterol and 0.6% sodium deoxycholate). RESULTS: Cholesterol can be used to construct a mouse model of hyperlipidemia. [4]
Source	Natural Products > Oleaceae > Olea

Synonyms	Cholesterin, Cholesteryl alcohol
Molecular Weight	386.664
Formula	C27H46O
CAS No.	57-88-5

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Insoluble

Ethanol: 10 mg/mL(25.86 mM)

H2O: Insoluble

References and Literature

1. Sengupta S, et al. Cholesterol-dependent plasma membrane order (Lo) is critical for antigen-specific clonal expansion of CD4+ T cells. Sci Rep. 2021 Jul 7;11(1):13970. 2. Lim SC, et al. Cholesterol induces autophagic and apoptotic death in gastric carcinoma cells. Int J Oncol. 2014 Mar;44(3):805-11. 3. Tawara K, et al. Mode of action of probucol in reducing serum cholesterol in mice. Jpn J Pharmacol. 1986 Jan;40(1):123-33. 4. Díaz-Zagoya JC, et al. Effects of high rosuvastatin doses on hepatocyte mitochondria of hypercholesterolemic mice. Sci Rep. 2021 Aug 4;11(1):15809.

Citations

1. Qiao S, Bao L, Wang K, et al. Activation of a Specific Gut Bacteroides-Folate-Liver Axis Benefits for the Alleviation of Nonalcoholic Hepatic Steatosis. Cell Reports. 2020, 32(6): 108005 2. Fang X X, Wei P, Zhao K, et al.Fatty acid–binding proteins 3, 7, and 8 bind cholesterol and facilitate its egress from lysosomes.Journal of Cell Biology.2024, 223(4).

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Keywords

Cholesterol 57-88-5 Endocrinology/Hormones Immunology/Inflammation Metabolism Estrogen Receptor/ERR MRP Endogenous Metabolite ROR ERRα AKT SREBP2 exocytic Cholesterin signaling insulin Inhibitor inhibit IRS-1 unesterified Cholesteryl alcohol phosphorylation Diabetes transporters inhibitor

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