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PROTAC ERRα Degrader-3

Catalog No. T39837 CAS 2306388-65-6

PROTAC ERRα Degrader-3 is a highly effective and selective von Hippel-Lindau-based ligand that efficiently degrades the ERRα protein. At a concentration of 30 nM, this compound exhibits a remarkable degradation capability, reducing the ERRα protein levels by <80%. Importantly, PROTAC ERRα Degrader-3 shows no activity against the ERRβ and ERRγ proteins.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

PROTAC ERRα Degrader-3 Chemical Structure

PROTAC ERRα Degrader-3, CAS 2306388-65-6

Pack Size	Availability	Price/USD
5 mg	Inquiry	$ 249.00
10 mg	Inquiry	$ 398.00
25 mg	Inquiry	$ 788.00
50 mg	Inquiry	$ 1,190.00
100 mg	Inquiry	Inquiry
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Biological Description

Chemical Properties

Storage & Solubility Information

Description

PROTAC ERRα Degrader-3 is a highly effective and selective von Hippel-Lindau-based ligand that efficiently degrades the ERRα protein. At a concentration of 30 nM, this compound exhibits a remarkable degradation capability, reducing the ERRα protein levels by >80%. Importantly, PROTAC ERRα Degrader-3 shows no activity against the ERRβ and ERRγ proteins.

In vitro

PROTAC ERRα Degrader-3 (compound 6c; 0.3 nM-10 μM; 4 hours) effectively induces the degradation of ERRα in a dose-dependent manner, achieving significant degradation with doses as low as 3.0 nM within 4 hours. This compound also significantly reduces the levels of ERRα downstream target genes, such as ATP5B, medium-chain acyl CoA dehydrogenase (MCAD), and pyruvate dehydrogenase kinase 4 (PDK4), in MDA-MB-231 cells following 24 hours of exposure. Furthermore, PROTAC ERRα Degrader-3 disrupts the protein-protein interaction between ERRα and the PGC-1α peptide, marked by an IC50 of 12.67 nM, and induces approximately 96% degradation of the ERRα protein at a concentration of 100 nM after 4 hours. Western Blot analysis in MDA-MB-231 cells across a range of concentrations (0.3 nM to 10 μM) and a 4-hour incubation period corroborates the dose-dependent mechanism of ERRα degradation.

Molecular Weight	957.0
Formula	C47H50F6N6O7S
CAS No.	2306388-65-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Lijie Peng, et al. Identification of New Small-Molecule Inducers of Estrogen-related Receptor α (ERRα) Degradation. ACS Med Chem Lett. 2019 Apr 12;10(5):767-772.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

PROTAC ERRα Degrader-3 2306388-65-6 PROTAC ERRalpha Degrader-3 PROTAC ERRα Degrader3 PROTAC ERRα Degrader 3 PROTAC ERRa Degrader-3 inhibitor inhibit

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