20
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T17879 | E3 ligase Ligand 8 | Others , Ligand for E3 Ligase | |
E3 ligase Ligand 8 is a ligand for E3 ubiquitin ligase. The E3 ligase Ligand 8 can be linked to protein ligands through linkers to form PROTACs, which are inducers of ubiquitination-mediated degradation of cancer-promoti... | |||
T40503 | Thalidomide-5-methyl | Ligand for E3 Ligase | |
Thalidomide-5-methyl is the Thalidomide-based cereblon (CRBN) ligand. Thalidomide-5-methyl is used in the recruitment of CRBN protein. | |||
T18831 | Thalidomide-propargyl | Others , Ligand for E3 Ligase | |
Thalidomide-propargyl, a Thalidomide-derived Cereblon ligand, facilitates the recruitment of Cereblon. It can be attached to the protein ligand via a linker, producing IMiD-containing PROTACs. | |||
T18066 | Lenalidomide-OH | Ligand for E3 Ligase | |
Lenalidomide-OH is an analog of Lenalidomide, a cereblon ligand for E3 ubiquitin ligase (CRBN), used for CRBN protein recruitment. It is able to attach to protein ligands using linkers to form PROTAC. | |||
T14893 | CC-885 | Others , Ligand for E3 Ligase | |
CC-885 is a modulator of cereblon (CRBN). It has potent anti-tumour activity. | |||
T5334 | VL285 | Others , Ligand for E3 Ligase | |
VL285 is a potent VHL ligand, degrading HaloTag7 fusion proteins. | |||
T9809 | E3 ligase Ligand 23 | Ligand for E3 Ligase | |
E3 ligase Ligand 23 is a cereblon binding agent that degrades Ikaros or Aiolos via the ubiquitin proteasome. | |||
TQ0121 | VH-298 | Others , HIF , Ligand for E3 Ligase | |
VH-298 is a potent inhibitor of VHL that stabilizes HIF-α and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL:HIF-α protein-protein interaction downstream of HIF-α hydroxylation by P... | |||
T18064 | Lenalidomide-Br | Ligand for E3 Ligase | |
Lenalidomide-Br is an analog of the cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, which is used in the recruitment of CRBN proteins. It is able to utilize linkers to attach to protein ligands to form PROTA... | |||
T7763 | Thalidomide-4-OH | Cereblon ligand 2,E3 ligase Ligand 2 | Ligand for E3 Ligase |
Thalidomide-4-OH (E3 ligase Ligand 2) (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used to recruit of CRBN protein. Thalidomide-4-OH (Cereblon ligand 2) is a linker to form PROTACs | |||
T0213 | Thalidomide | Thalomid,Sedoval | Apoptosis , TNF , Autophagy , Ligand for E3 Ligase , Molecular Glues |
Thalidomide (Thalomid) is a synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic properties. | |||
T7752 | (S,R,S)-AHPC-Me | VHL ligand 2,E3 ligase Ligand 1A | Ligand for E3 Ligase |
(S,R,S)-AHPC-Me is a VHL ligand based on (S,R,S)-AHPC that can be used to recruit von Hippel-Lindau (VHL) proteins. It efficiently degrades BET proteins in desmoplasia-resistant prostate cancer cells with a DC50 < 1 nM, ... | |||
T8824 | CRBN modulator-1 | WUN29654 | Others , Ligand for E3 Ligase |
CRBN modulator-1 (WUN29654) is a Thalidomide analog and CRBN modulator,has an IC50 of 3.5 μM and a Ki of 0.98 μM. | |||
T60024 | CFT7455 | Cemsidomide | Ligand for E3 Ligase |
CFT7455 (Cemsidomide) is an anti-cancer agent showing high affinity to the cereblon E3 ligase with a Kd of 0.9 nM. CFT7455 is an orally active degrader of zinc finger transcription factors Ikaros (IKZF1), and Aiolos (IKZ... | |||
T22922 | Lenalidomide hemihydrate | TNF , Ligand for E3 Ligase , Molecular Glues | |
Lenalidomide hemihydrate is a derivative of Thalidomide, an orally active immunomodulator that acts as a molecular gel. It is a ligand for the ubiquitin E3 ligase cereblon, which selectively ubiquitinates and degrades tw... | |||
T40019 | Thalidomide-5-NH2-CH2-COOH | Others | |
Thalidomide-5-NH2-CH2-COOH (compound 114) is a selective inhibitor of the protomyosin receptor kinase. It is a ligand for E3 ligase and has potential for studying one or more diseases. | |||
T10359 | AR antagonist 1 | Androgen Receptor , Ligand for E3 Ligase , Ligands for Target Protein for PROTAC | |
AR antagonist 1 is a potent antagonist of the androgen receptor. It binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PROTAC ARD-266. | |||
T7753 | Thalidomide-O-COOH | Cereblon ligand 3,E3 ligase Ligand 3,TCE35031 | Others , Ligand for E3 Ligase |
Thalidomide-O-COOH (Cereblon ligand 3) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. It can be connected to the ligand for protein by a linker to form PROTACs. | |||
T5821 | BC-1215 | Others , Ligand for E3 Ligase | |
BC-1215 is an inhibitor of F-box protein 3 (FBXO3, a ubiquitin E3 ligase component, IC50=0.9 μg/mL for IL-1β release). | |||
T2384 | Pomalidomide | CC-4047 | Apoptosis , TNF , Ligand for E3 Ligase , Molecular Glues |
Pomalidomide (CC-4047) inhibits TNF-α release in LPS stimulated human PBMCs (IC50: 13 nM). It is an anti-angiogenic agent and an immunomodulator. |