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Thalidomide

Catalog No. T0213   CAS 50-35-1
Synonyms: Thalomid, Sedoval

Thalidomide (Thalomid) is a synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic properties.

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Thalidomide Chemical Structure
Thalidomide, CAS 50-35-1
Pack Size Availability Price/USD Quantity
200 mg In stock $ 50.00
500 mg In stock $ 97.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 99.88%
Purity: 98.88%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Thalidomide (Thalomid) is a synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic properties.
Targets&IC50 CRL4CRBN:250 nM (Kd)
Synonyms Thalomid, Sedoval
Molecular Weight 258.23
Formula C13H10N2O4
CAS No. 50-35-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 6.5 mg/mL (25 mM)

TargetMolReferences and Literature

1. D'Amato RJ, et al. Proc Natl Acad Sci U S A, 1994, 91(9), 4082-4085. 2. Sampaio EP, et al. J Exp Med, 1991, 173(3), 699-703. 3. Moreira AL, et al. J Exp Med, 1993, 177(6), 1675-1680. 4. Hideshima T, et al. Blood, 2000, 96(9), 2943-2950. 5. Haslett PA, et al. J Exp Med, 1998, 187(11), 1885-1892. 6. Bian C, et al. Thalidomide (THD) alleviates radiation induced lung fibrosis (RILF) via down-regulation of TGF-β/Smad3 signaling pathway in an Nrf2-dependent manner. Free Radic Biol Med. 2018 Dec;129:446-453. 7. Sun X, et al. Synergistic Inhibition of Thalidomide and Icotinib on Human Non-Small Cell Lung Carcinomas Through ERK and AKT Signaling. Med Sci Monit. 2018 May 15;24:3193-3203. 8. Guo Y, Fan Y, Pei X. Fangjihuangqi Decoction inhibits MDA‐MB‐231 cell invasion in vitro and decreases tumor growth and metastasis in triple‐negative breast cancer xenografts tumor zebrafish model[J]. Cancer Medicine. 2020, 9(7): 2564-2578.

TargetMolCitations

1. Lü Z, Li X, Li K, et al. Nitazoxanide and related thiazolides induce cell death in cancer cells by targeting the 20S proteasome with novel binding modes. Biochemical Pharmacology. 2022: 114913. 2. Guo Y, Fan Y, Pei X. Fangjihuangqi Decoction inhibits MDA‐MB‐231 cell invasion in vitro and decreases tumor growth and metastasis in triple‐negative breast cancer xenografts tumor zebrafish model. Cancer Medicine. 2020, 9(7): 2564-2578.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Active Compound Library Approved Drug Library Pyroptosis Compound Library Cardiotoxicity Compound Library FDA-Approved Drug Library Angiogenesis related Compound Library Cytokine Inhibitor Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Thalidomide 50-35-1 Apoptosis Autophagy PROTAC TNF Ligand for E3 Ligase Molecular Glues Ligands for E3 Ligase inhibit Thalomid E3 ligase-recruiting Moiety Inhibitor Sedoval inhibitor

 

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