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BC-1215

Catalog No. T5821 CAS 1507370-20-8

BC-1215 is an inhibitor of F-box protein 3 (FBXO3, a ubiquitin E3 ligase component, IC50=0.9 μg/mL for IL-1β release).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

BC-1215, CAS 1507370-20-8

Pack Size	Availability	Price/USD
5 mg	In stock	$ 47.00
10 mg	In stock	$ 77.00
25 mg	In stock	$ 128.00
50 mg	In stock	$ 189.00
100 mg	In stock	$ 279.00
1 mL * 10 mM (in DMSO)	In stock	$ 52.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	BC-1215 is an inhibitor of F-box protein 3 (FBXO3, a ubiquitin E3 ligase component, IC50=0.9 μg/mL for IL-1β release).
Targets&IC50	FBXO3:0.9 μg/mL
In vivo	A small molecule inhibitor BC-1215 argeting Fbxo3 was sufficient to lessen severity of cytokine-driven inflammation in several murine disease models.
Animal Research	Tested effects of administration of BC-1215 in a model of a cecal ligation and puncture (CLP)-induced sepsis. Mice with CLP had significantly increased cytokine release compared to sham treated mice. BC-1215 treatment significantly attenuated CLP-induced secretion of all three circulating pro-inflammatory cytokines in mice . BC-1215 also decreased bacterial counts in the CLP model and modestly produced inhibition of bacterial growth using Kirby Bauer testing

Molecular Weight	394.51
Formula	C26H26N4
CAS No.	1507370-20-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 3.94 mg/mL (10 mM)

References and Literature

1. Bill B. Chen,Tiffany A. Coon,Jennifer R. Glasser,et, al. A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation[J].Nat Immunol. 2013 May; 14(5): 470–479.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Ubiquitination Compound Library NO PAINS Compound Library Anti-COVID-19 Compound Library Bioactive Compounds Library Max Bioactive Compound Library Immunology/Inflammation Compound Library HIF-1 Signaling Pathway Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BC-1215 1507370-20-8 Others PROTAC Ligand for E3 Ligase Ligands for E3 Ligase E3 ligase-recruiting Moiety F-box protein 3 (Fbxo3) Inhibitor inhibit inflammation MLE cells BC1215 PBMC cells U937 cells TRAF BC 1215 inhibitor

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