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Lenalidomide-Br

Catalog No. T18064 CAS 2093387-36-9

Lenalidomide-Br (Compound 41) is a derivative of Lenalidomide, which serves as a ligand for cereblon (CRBN) - an E3 ubiquitin ligase involved in protein recruitment. This compound, Lenalidomide-Br, can be conjugated to a protein ligand through a linker to create PROTACs. For instance, Lenalidomide-Br is utilized as a component in the PROTAC STAT3 degrader SD-36.

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Lenalidomide-Br, CAS 2093387-36-9

Pack Size	Availability	Price/USD	Quantity
100 mg	In stock	$ 50.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 98.37%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Lenalidomide-Br (Compound 41) is a derivative of Lenalidomide, which serves as a ligand for cereblon (CRBN) - an E3 ubiquitin ligase involved in protein recruitment. This compound, Lenalidomide-Br, can be conjugated to a protein ligand through a linker to create PROTACs. For instance, Lenalidomide-Br is utilized as a component in the PROTAC STAT3 degrader SD-36.
In vitro	Lenalidomide-Br can be conjugated to a protein ligand via a linker, forming PROTACs that induce the ubiquitination-mediated degradation of oncogenic proteins.
In vivo	Lenalidomide-Br can form a PROTAC by coupling with a protein's ligand. PROTAC acts as an inducer of ubiquitin-mediated degradation of oncogenic proteins [1][2].

Molecular Weight	323.14
Formula	C13H11BrN2O3
CAS No.	2093387-36-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (92.84 mM), Sonication is recommended.

References and Literature

1. Bai L, et al. A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo. Cancer Cell. 2019 Nov 11;36(5):498-511.e17. 2. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.

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Keywords

Lenalidomide-Br 2093387-36-9 PROTAC Ligand for E3 Ligase Ligands for E3 Ligase analog Inhibitor recruitment ubiquitin inhibit LenalidomideBr E3 ligase-recruiting Moiety cereblon Lenalidomide Br ligase protein inhibitor

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