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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T60940 | ChE/Aβ1-42-IN-1 | ||
ChE/Aβ1-42-IN-1 (compound 28) is a potent aggregation inhibitor of ChE and Aβ 1-42 with excellent BBB permeability. The IC50 values of ChE/Aβ1-42-IN-1 for AChE, BuChE and Aβ 1-42 aggregation are 0.062, 0.767 and 1.227 μM... | |||
TN1091 | Dehydronuciferine | AChE | |
Dehydronuciferine is isolated from the leaves of Nelumbo nucifera Gaertn. Dehydronuciferine shows inhibitory of acetylcholinesterase with the IC50 of 25 ug/mL. | |||
T3852 | Rhodiosin | Antioxidant , AChE | |
Rhodiosin is a compound with antioxidant activity. | |||
TN1011 | Rhodionin | P450 , AChE | |
Rhodionin and rhodionin can inhibit cytochrome P450 2D6 non-competitively with high specificity which could have implications for interactions with co-administered drugs; they can significantly suppress the elevation of ... | |||
T13301 | Violanthin | AChE | |
Violanthin is a natural product isolated from the aerial parts of Piper bavinum and inhibits acetylcholinesterase (AChE) (IC50: 79.80 μM). It has potent antioxidant and antibacterial activities. | |||
T2846 | Isoimperatorin | Antibacterial , AChE | |
Isoimperatorin is an anti-inflammatory agent, exhibits significant inhibitory effects on acetylcholinesterase (AChE). | |||
T5855 | Edrophonium chloride | AChE | |
Edrophonium chloride is an acetylcholinesterase (AChE) inhibitor that is known to prevent the breakdown of the neurotransmitter acetylcholine by binding specifically to its catalytic site. | |||
T5S2361 | Epiberberine | ERK , Beta-Secretase , MEK , BACE , AMPK , AChR , AChE | |
1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf/MEK1/ERK1/2 and AMPKα/Akt pathways during 3T3-L1 adipocyte diffe... | |||
TN1589 | Dihydrowithaferin A | AChE | |
Dihydrowithaferin A is a withanolide isolated from Withania somnifera with activity against acetylcholinesterase (AChE). Dihydrowithaferin A in the diet may prevent or decrease the growth of tumors. | |||
T13469 | (±)-Huperzine A | AChE | |
(±)-Huperzine A is an active Lycopodium alkaloid extracted from traditional Chinese herbs. (±)-Huperzine A is a selective and reversible inhibitor of AChE and can be used in studies about the treatment of Alzheimer's dis... | |||
TN1858 | Leptomerine | AChE | |
Leptomerine (IC50 = 2.5 mM) shows potent anticholinesterasic activity. | |||
T5S1408 | Pteryxin | (+)-Pteryxin | Others , AChE |
(+)-Pteryxin ((+)-Pteryxin) has muscle-relaxant props. (+)-Pteryxin shows hepatoprotective and nitric oxide prodn. inhibitory activity. | |||
TN1899 | Lycoramine | AChE | |
Lycoramine is a natural product isolated from Lycoris radiate. Lycoramine is a potent acetylcholinesterase (AChE) inhibitor | |||
T13681 | Epi-galantamine | AChE | |
Epi-galantamine, a diastereomer of galantamine, is an alkaloid extracted from the bulbs and flowers of the Caucasian snowdrop (Galanthus woronowii). It acts as an AChE inhibitor, featuring an EC50 of 45.7 μM. | |||
T14194 | β-NETA | α-NETA | AChE |
β-NETA (α-NETA) is a stable, noncompetitive, slowly reversible choline acetyltransferase (ChAT) inhibitor with an IC50 of 9 μM and is a potent chemokine-like receptor-1 (CMKLR1) antagonist. β-NETA has anti-cancer activit... | |||
T19084 | 1-Naphthyl acetate | AChE | |
1-Naphthyl acetate is usually used in a rapid staining method for identification of macrophages. 1-Naphthyl acetate is a potent chromogenic substrate for the detection of erythrocyte acetylcholinesterase (AChE) activity.... | |||
T4S1725 | Galanthamine | Galantamine | Apoptosis , AChE |
Galanthamine (Galantamine) is an acetylcholinesterase (AChE)inhibitor(IC50 : 500 nM), can reduce brain damage induced by hypoxia-ischemia. | |||
TN1786 | Isomerazin | Isomeranzin | ERK , NF-κB , AChE |
Isomerazin (Isomeranzin) has anti-inflammatory activity, it suppresses inflammation by inhibiting M1 macrophage polarization through the p65, NF-κB and ERK pathway. | |||
T9989 | AChE-IN-27 | Others | |
AChE-IN-27 is a small molecule used for high-throughput assays. | |||
T3769 | Tenuifolin | Others , Beta-Secretase , AChE | |
Tenuifolin has no inherent toxicity to either the transfected or wild type cells at the effective concentrations, it inhibits amyloid-β secretion in vitro. |