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Search Result

Search Results for " chk2 "

Targets

Apoptosis Chk

28

Compounds

3

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T2033 BML-277 C 3742,Chk2 Inhibitor II,BML 277 Apoptosis , Chk
BML-277 (C 3742) is a selective checkpoint kinase 2 (Chk2) inhibitor.
T6028 PF 477736 PF 00477736,PF-477736,PF-736,PF-00477736,PF477736 c-Fms , VEGFR , FGFR , FLT , c-RET , Chk , CDK , Src , Aurora Kinase
PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (CSF1R), Ret and Yes.
T10718L CCT241533 hydrochloride Chk
CCT241533 hydrochloride is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).
T71259 GNE-900 GNE900,GNE 900 Apoptosis , Chk
GNE-900 is an ATP-competitive ChK1 inhibitor with selective and oral activity.GNE-900 inhibits ChKl and ChK2 with IC50 values of 0.0011 and 1.5 µM, respectively.GNE-900 enhances DNA damage and induces apoptosis. GNE-900 ...
T3700 SCH900776 (S-isomer) MK-8776 S-isomer,SCH900776 S-isomer Chk , CDK
SCH900776 S-isomer (MK-8776 S-isomer) is an effective, specific and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50: 3 nM). It also inhibitors Chk2 (IC50: 1500 nM) and cyclin-dependent kinase CDK2 (IC50: 16...
T4327 Prexasertib dihydrochloride LY2606368 (dihydrochloride),Prexasertib HCl,LY2606368 Apoptosis , Chk , S6 Kinase
Prexasertib dihydrochloride (LY2606368) is an ATP-competitive CHK1 inhibitor (Ki: 0.9 nmol/L). in the cell-free assay, its IC50 values are 8 nM and 9 nM for CHK2 and RSK, respectively.
T13148 CHK-IN-1 Chk
CHK-IN-1 is a dual inhibitor of CHK1 and CHK2 with antiproliferative activity.
T7080 CCT245737 SRA737 Chk
CCT245737 (SRA737) is an orally active and selective Chk1 inhibitor (IC50: 1.3 nM); CCT245737 shows much less activity against Chk2 (IC50: 2440 nM).
T6350 CHIR-124 CHIR124,CHIR 124 Apoptosis , GSK-3 , FLT , Chk , PDGFR , Src
CHIR-124 is an effective Chk1 inhibitor (IC50: 0.3 nM). It has 2, 000-fold selectivity against Chk2, 500- to 5, 000-fold less activity against Cdc2 and CDK2/4.
T6093 AZD-7762 AZD7762 Chk
AZD-7762, an effective and specific inhibitor of Chk1（IC50=5 nM）, is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck.
T6940 PHA-767491 hydrochloride CAY10572,PHA-767491,PHA767491 HCl,CAY-10572 hydrochloride Apoptosis , GSK-3 , CDK
PHA-767491 hydrochloride (CAY-10572 hydrochloride) is an effective ATP-competitive dual Cdc7/CDK9 inhibitor (IC50: 10/34 nM). It has ~20-fold selectivity against GSK3-β and CDK1/2, 50-fold selectivity against CDK5 and MK...
T2517 SCH900776 MK 8776,MK-8776 Chk , CDK
SCH900776 (MK-8776) is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities.
T21331 SAR-020106 Chk
SAR-020106 is a potent, ATP-competitive, and selective CHK1 inhibitor with an IC50 of 13.3 nmol/L on the isolated human enzyme.
T17223 VER-00158411 Chk
VER-00158411 is a checkpoint kinase 1 and CHK2 inhibitor (IC50: 4.4 nM and 4.5 nM, respectively).
T36704 CCT241533 dihydrochloride CCT 241533 dihydrochloride
Potent Chk2 inhibitor (IC50 = 3 nM). Shows >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. Inhibits Chk2 activation in response to etoposide-induced DNA damage in HT29 cells. Blocks ionizing radi...
T10718 CCT241533 Chk
CCT241533 is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).
T4310 Prexasertib LY2606368 Apoptosis , Chk
Prexasertib (LY2606368) is an inhibitor of checkpoint kinase 1 (chk1) with potential antineoplastic activity.
T24688 PV-1115 PV1115
PV-1115 is an effective and highly selective inhibitor of the Chk2.
T73411 PV-1019 NSC 744039
PV-1019 (NSC 744039) is a potent, selective inhibitor of Chk2, displaying an IC50 of 24 nM. It effectively inhibits Topotecan-induced Chk2 autophosphorylation and suppresses IR-induced apoptosis [1].
T23089 NSC 109555 ditosylate Others
Chk2 inhibitor,ATP-competitive
T29116 VRX-0466617
VRX-0466617 is a novel selective Chk2 inhibitor.
T38620 Prexasertib dimesylate LY2606368 dimesylate
Prexasertib dimesylate (LY2606368 dimesylate) is a highly selective ATP-competitive second-generation inhibitor of checkpoint kinase 1 (CHK1). With a K i of 0.9 nM and an IC 50 of <1 nM, Prexasertib dimesylate effectivel...
T4310L Prexasertib lactate hydrate Prexasertib monolactate monohydrate,LY-2606368,LY 2606368,LY2606368,Prexasertib monolactate monohydrate salt
Prexasertib is an effective and selective Chk1/Chk2 inhibitor. Prexasertib causes Replication Catastrophe and Antitumor Effects through CHK1-Dependent Mechanisms.
T4310L2 Prexasertib mesylate LY-2606368,LY2606368,LY 2606368
Prexasertib is a potent and selective Chk1/Chk2 inhibitor. Prexasertib increases the effectiveness of conventional therapy in B-/T- cell progenitor acute lymphoblastic leukemia. LY2606368 causes replication catastrophe a...
T71156 Poloxipan
Poloxipan is a potent and pan-specific PLK1 inhibitor. In vitro, Poloxipan has IC50 3.2 uM (Plk1); 1.7 uM (Plk2); and 3 uM (Plk3). Poloxipan showed minor inhibition over FHA dommain of Chk2, S2 domian of STAT1, STAT5b, L...
T15943 M443 p38 MAPK , Chk
M443 is a potent small molecule inhibitor of MRK that inhibits radiation-induced activation of p38 and Chk2 and can be used in cancer research.
T33737 NSC 109555 NSC-109555,DDUG dimethanesulfonate,NSC109555,DDUG diMS
NSC 109555 is a selective, reversible, ATP-competitive Chk2 inhibitor (IC50 = 0.2 μM) that displays no effect on a range of other kinases including Chk1 (IC50 > 10 μM). Inhibits histone H1 phosphorylation (IC50 = 0.24 μM...
T63152 Prexasertib Mesylate Hydrate
Prexasertib Mesylate Hydrate (LY2606368 Mesylate Hydrate) is an ATP-competitive, selective, second generation cell cycle detection site kinase 1 (CHK1) inhibitor (IC50<1 nM, Ki: 0.9 nM). Prexasertib Mesylate Hydrate inhi...

Compounds

BML-277
T2033
Synonym: C 3742,Chk2 Inhibitor II,BML 277
Target: Apoptosis, Chk
PF 477736
T6028
Synonym: PF 00477736,PF-477736,PF-736,PF-00477736,PF477736
Target: c-Fms, VEGFR, FGFR, FLT, c-RET, Chk, CDK, Src, Aurora Kinase
CCT241533 hydrochloride
T10718L
Synonym:
Target: Chk
GNE-900
T71259
Synonym: GNE900,GNE 900
Target: Apoptosis, Chk
SCH900776 (S-isomer)
T3700
Synonym: MK-8776 S-isomer,SCH900776 S-isomer
Target: Chk, CDK
Prexasertib dihydrochloride
T4327
Synonym: LY2606368 (dihydrochloride),Prexasertib HCl,LY2606368
Target: Apoptosis, Chk, S6 Kinase
CHK-IN-1
T13148
Synonym:
Target: Chk
CCT245737
T7080
Synonym: SRA737
Target: Chk
CHIR-124
T6350
Synonym: CHIR124,CHIR 124
Target: Apoptosis, GSK-3, FLT, Chk, PDGFR, Src
AZD-7762
T6093
Synonym: AZD7762
Target: Chk
PHA-767491 hydrochloride
T6940
Synonym: CAY10572,PHA-767491,PHA767491 HCl,CAY-10572 hydrochloride
Target: Apoptosis, GSK-3, CDK
SCH900776
T2517
Synonym: MK 8776,MK-8776
Target: Chk, CDK
SAR-020106
T21331
Synonym:
Target: Chk
VER-00158411
T17223
Synonym:
Target: Chk
CCT241533 dihydrochloride
T36704
Synonym: CCT 241533 dihydrochloride
Target:
CCT241533
T10718
Synonym:
Target: Chk
Prexasertib
T4310
Synonym: LY2606368
Target: Apoptosis, Chk
PV-1115
T24688
Synonym: PV1115
Target:
PV-1019
T73411
Synonym: NSC 744039
Target:
NSC 109555 ditosylate
T23089
Synonym:
Target: Others
VRX-0466617
T29116
Synonym:
Target:
Prexasertib dimesylate
T38620
Synonym: LY2606368 dimesylate
Target:
Prexasertib lactate hydrate
T4310L
Synonym: Prexasertib monolactate monohydrate,LY-2606368,LY 2606368,LY2606368,Prexasertib monolactate monohydrate salt
Target:
Prexasertib mesylate
T4310L2
Synonym: LY-2606368,LY2606368,LY 2606368
Target:
Poloxipan
T71156
Synonym:
Target:
M443
T15943
Synonym:
Target: p38 MAPK, Chk
NSC 109555
T33737
Synonym: NSC-109555,DDUG dimethanesulfonate,NSC109555,DDUG diMS
Target:
Prexasertib Mesylate Hydrate
T63152
Synonym:
Target:

Recombinant Proteins

Species：
Human (2)
Mouse (1)
Expression System：
Baculovirus Insect Cells (2)
HEK293 Cells (1)
Tag：
C-mFc (1)
His, GST (1)
N-GST (1)
Cat No. Product Name Species Expression System
TMPY-04435 CHEK2 Protein, Mouse, Recombinant (His & GST) Mouse Baculovirus Insect Cells
CHEK2 Protein, Mouse, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 89 kDa and the accession number is Q9Z265.
TMPY-04681 CHEK2 Protein, Human, Recombinant (GST) Human Baculovirus Insect Cells
CHEK2 Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 88.1 kDa and the accession number is O96017-1.
TMPY-00369 LY6D Protein, Human, Recombinant (mFc) Human HEK293 Cells
LY6D (Lymphocyte Antigen 6 Family Member D) is a Protein Coding gene. It may act as a specification marker at the earliest stage specification of lymphocytes between B- and T-cell development. Marks the earliest stage of...
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