store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
M443 is a potent small molecule inhibitor of MRK that inhibits radiation-induced activation of p38 and Chk2 and can be used in cancer research.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | 6-8 weeks | $ 427.00 | |
25 mg | 6-8 weeks | $ 1,330.00 | |
50 mg | 6-8 weeks | $ 1,740.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | M443 is a potent small molecule inhibitor of MRK that inhibits radiation-induced activation of p38 and Chk2 and can be used in cancer research. |
Targets&IC50 | MRK:<125 nM |
In vitro | The osmotic pumps were filled with a solution of 0.05 mg/ml M443 or vehicle [0.01% DMSO in PBS], and implanted into the backs of animals. The results showed that treatment with M443 alone extended the survival of mice by 5.5 days. |
In vivo | As a time-dependent irreversible MRK inhibitor, M443 (500 nM) significantly inhibits the activation of MRK, Chk2, and p38 stimulated by IR. |
Molecular Weight | 589.61 |
Formula | C31H30F3N7O2 |
CAS No. | 1820684-31-8 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (50.88 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
M443 1820684-31-8 Cell Cycle/Checkpoint MAPK Chk p38 MAPK M 443 M-443 inhibitor inhibit