Search Result

Search Results for " cd28 "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T3189	B7/CD28 interaction inhibitor 1	CTLA-4 inhibitor	Others
	B7/CD28 interaction inhibitor 1 (CTLA-4 inhibitor) is a potent CTLA-4 inhibitor.		Others
T78255	Anti-Mouse CD28 Antibody (37.51)
	Anti-Mouse CD28 Antibody is a Syrian Hamster-derived IgG inhibitor targeting mouse CD28.
T10722	CD80-IN-3		Bombesin Receptor
	CD80-IN-3 is a potent CD80 inhibitor and inhibits CD80/CD28 interaction (Kd: 125 nM; EC50: 630 nM).		Bombesin Receptor
T8924	MFCD28987368		Others
	MFCD28987368 is a degradable ADC linker that can be used in the synthesis of antibody coupled drugs (ADCs).		Others
T78274	Omburtamab
	Omburtamab, an anti-CD276 (also known as B7-H3) monoclonal antibody, targets the B7/CD28 family protein CD276, prevalent in solid human tumors. This binding capability positions omburtamab as a potential research tool in...
T77093	Theralizumab	TGN1412,TAB-08,TABO8	Others
	Theralizumab (TGN1412) is an anti-CD28-targeting monoclonal antibody that directly stimulates T cells. Theralizumab has antitumor activity and is used for the treatment of B-cell chronic lymphocytic leukemia and rheumato...		Others
T63790	Cbl-b-IN-3		E1/E2/E3 Enzyme
	Cbl-b-IN-3 is a potent proto-oncogene-B (CPL-B) inhibitor of casitas B-series lymphoma (ic50 < 1 nM). Cpl-b, a cyclic E3 ubiquitin protein ligase, is involved in the setting of T lymphocyte activation thresholds. Cpl-b n...		E1/E2/E3 Enzyme
T76817	Lulizumab
	Lulizumab, a humanized anti-CD28 recombinant antibody, functions as a selective CD28 blockade. By specifically targeting CD28 signaling, it inhibits T cell activation [1].
T26367	Reltecimod	NSC-37096,P2TA,AB-103,AB103,P-2TA
	Reltecimod, a CD28 antigen inhibitor, is used potentially for the treatment of necrotizing soft tissue infection.
T26367L	Reltecimod sodium	AB 103 sodium,AB-103 sodium,AB103 sodium
	Reltecimod sodium, a CD28 antigen inhibitor, is used potentially for the treatment of necrotizing soft tissue infection.
T78107	Reltecimod TFA	AB-103 TFA
	Reltecimod (AB-103) TFA is an antagonist of the T-cell-specific surface glycoprotein CD28 (TP44), demonstrating efficacy against various bacterial infections, including their exotoxins and endotoxins, as well as ionizing...
T77074	Lulizumab pegol
	Lulizumab pegol (BMS-931699) is an antagonist anti-CD28 antibody that effectively inhibits T-cell proliferation, making it a potential therapeutic agent for kidney transplantation and autoimmunity disease research [1].
T79791	Immunosuppressant-1		Apoptosis
	Immunosuppressant-1 (Compound 31) suppresses T-cell proliferation triggered by anti-CD3/anti-CD28 co-stimulation and demonstrates immunosuppressive effects, including the induction of apoptosis in activated lymph node ce...		Apoptosis
T37604	ITK inhibitor
	Interleukin-2-inducible T cell kinase (ITK) is a non-receptor tyrosine kinase expressed in T cells, NKT cells and mast cells which plays a crucial role in regulating the T cell receptor (TCR), CD28, CD2, chemokine recept...

Compounds

B7/CD28 interaction inhibitor 1

T3189

Synonym: CTLA-4 inhibitor

Target: Others

Anti-Mouse CD28 Antibody (37.51)

Target: Bombesin Receptor

Synonym: TGN1412,TAB-08,TABO8

Target: E1/E2/E3 Enzyme

Synonym: NSC-37096,P2TA,AB-103,AB103,P-2TA

Target:

Reltecimod sodium

T26367L

Synonym: AB 103 sodium,AB-103 sodium,AB103 sodium

Cat No.	Product Name	Synonyms	Targets
TN1110	Shanziside	Shanzhiside	IL Receptor
	Shanziside (Shanzhiside) has immunosuppressive activity, it shows significant inhibition of IL-2 secretion by phorbol myristate acetate and anti-CD28 monoclonal antibody co-stimulated activation of human peripheral blood...		IL Receptor
T72858	Maydispenoid B
	Maydispenoid B, a potent immunosuppressor, effectively inhibits the proliferation of murine splenocytes activated by anti-CD3/anti-CD28 monoclonal antibodies (mAbs) and lipopolysaccharide.
T72857	Maydispenoid A
	Maydispenoid A, a potent immunosuppressive compound, effectively inhibits murine splenocyte proliferation activated by both anti-CD3/anti-CD28 monoclonal antibodies (mAbs) and lipopolysaccharide.

Natural Products

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-01941	CD28 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	CD28 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42 kDa and the accession number is P10747-1.
TMPJ-00103	CD28 Protein, Human/Cynomolgus, Recombinant (His)	Human,Cynomolgus	HEK293 Cells
	CD28 Protein, Human/Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 30-40 KDa and the accession number is P10747.
TMPY-06021	CD28 Protein, Human, Cynomolgus, Rhesus, Recombinant (His)	Human,Cynomolgus,Rhesus	HEK293 Cells
	CD28 Protein, Human, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16.6 kDa and the accession number is Q0PDN3.
TMPY-05354	CD28 Protein, Human, Recombinant (hFc & Avi), Biotinylated	Human	HEK293 Cells
	CD28 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 43.7 kDa and the accession number is P10747-1.
TMPK-01176	CD28 Protein, Canine, Recombinant (His)	Canine	HEK293 Cells
	CD28 is the receptor for CD80 (B7-1) and CD86 (B7-2) proteins.When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting...
TMPK-01177	CD28 Protein, Canine, Recombinant (mFc)	Canine	HEK293 Cells
	CD28 is the receptor for CD80 (B7-1) and CD86 (B7-2) proteins.When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting...
TMPY-00004	CD28 Protein, Rat, Recombinant (hFc)	Rat	HEK293 Cells
	CD28 (Cluster of Differentiation 28) is a disulphide-bonded glycoprotein belonging to the immunoglobulin (Ig) superfamily, and structurally consists of a single Ig V-like extracellular domain, a transmembrane domain and ...
TMPY-04252	CD28 Protein, Rat, Recombinant (His)	Rat	HEK293 Cells
	CD28 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16.4 kDa and the accession number is A6IPD4.
TMPY-00036	CD28 Protein, Cynomolgus, Recombinant (hFc)	Cynomolgus	HEK293 Cells
	CD28 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 41.9 kDa and the accession number is Q0PDN3.
TMPY-05391	CD28 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	CD28 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 41.8 kDa and the accession number is P31041.
TMPY-01955	CD28 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	CD28 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16.5 kDa and the accession number is P31041.
TMPY-05652	CD28 Protein, Mouse, Recombinant (His), Biotinylated	Mouse	HEK293 Cells
	CD28 Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16.5 kDa and the accession number is P31041.
TMPY-06374	CD28 Protein, Human, Cynomolgus, Rhesus, Recombinant (mFc)	Human,Cynomolgus,Rhesus	HEK293 Cells
	CD28 Protein, Human, Cynomolgus, Rhesus, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 41.52 kDa and the accession number is P10747-1.
TMPJ-00102	CD28 Protein, Human/Cynomolgus, Recombinant (hFc & Avi), Biotinylated	Human,Cynomolyus	HEK293 Cells
	CD28 Protein, Human/Cynomolgus, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-Fc-Avi tag. The predicted molecular weight is 60-90 KDa and the accession number is P10747.
TMPJ-00099	CD28 Protein, Mouse, Recombinant (hFc & His)	Mouse	HEK293 Cells
	T-cell-specific surface glycoprotein CD28, contains an Ig-like V-type domain. CD28 is one of the proteins expressed on T cells that provide co-stimulatory signals, which are required for their activation. It is the recep...
TMPK-00110	CD28 Protein, Human/Cynomolgus/Rhesus macaque, Recombinant (His & Avi)	Human,Cynomolgus,Rhesus	HEK293 Cells
	CD28 is the receptor for CD80 (B7-1) and CD86 (B7-2) proteins.When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting...
TMPY-06622	CD28 Protein, Human, Cynomolgus, Rhesus, Recombinant (His & Avi), Biotinylated	Human,Cynomolgus,Rhesus	HEK293 Cells
	CD28 Protein, Human, Cynomolgus, Rhesus, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 18.40 kDa and the accession number is P10747-1...
TMPK-00111	CD28 Protein, Human/Cynomolgus/Rhesus macaque, Recombinant (His & Avi), Biotinylated	Human,Cynomolgus,Rhesus	HEK293 Cells
	CD28 is the receptor for CD80 (B7-1) and CD86 (B7-2) proteins.When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting...
TMPY-05586	CD28H/TMIGD2 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	The orthologue of human IGPR-1 is found only in eukaryotes, including primates, the guinea pig, canines, felines, dolphins, bovines, the llama, bats, the common shrew, and horses. Of interest, the IGPR-1 gene is absent i...
TMPY-00478	CD28H/TMIGD2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	The orthologue of human IGPR-1 is found only in eukaryotes, including primates, the guinea pig, canines, felines, dolphins, bovines, the llama, bats, the common shrew, and horses. Of interest, the IGPR-1 gene is absent i...
TMPY-05440	CD28H/TMIGD2 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	The orthologue of human IGPR-1 is found only in eukaryotes, including primates, the guinea pig, canines, felines, dolphins, bovines, the llama, bats, the common shrew, and horses. Of interest, the IGPR-1 gene is absent i...
TMPK-00087	ICOS Protein, Human, Recombinant (C136S & C137S, His)	Human	HEK293 Cells
	Inducible co-stimulator (ICOS), also called AILIM (activiation-inducible lymphocyte immunomediatory molecule) and CRP-1 (CD28-related protein-1), is a member of the growing CD28 family of immune costimulatory receptors. ...
TMPK-00086	ICOS Protein, Human, Recombinant (aa 21-134, His)	Human	HEK293 Cells
	Inducible co-stimulator (ICOS), also called AILIM (activiation-inducible lymphocyte immunomediatory molecule) and CRP-1 (CD28-related protein-1), is a member of the growing CD28 family of immune costimulatory receptors. ...
TMPJ-00958	B7-1 Protein, Rabbit, Recombinant (His)	Rabbit	HEK293 Cells
	Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily which plays key, yet distinct roles in the activation of T cells. B7-1/CD80 and B7-2/CD86, together with their recep...
TMPJ-00420	CTLA-4 Protein, Mouse, Recombinant (Flag)	Mouse	HEK293 Cells
	Mouse Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule. Within the ECD, Mouse CTLA-4 shares 68% aa sequence identity with human. CTLA4 is similar to the T cell costimulatory pro...
TMPJ-00630	B7-1 Protein, Cynomolgus, Recombinant (hFc)	Cynomolgus	HEK293 Cells
	Cynomologous Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily.It is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and...
TMPH-01871	Plastin-2 Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69. Plastin-2 Protein, Human, Recom...
TMPH-01872	Plastin-2 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69. Plastin-2 Protein, Human, Recom...
TMPK-00178	B7-1 Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	Cluster of differentiation 80 (also CD80 and B7-1) is a protein found on dendritic cells, activated B cells and monocytes that provides a costimulatory signal necessary for T cell activation and survival. It is the ligan...
TMPK-00179	B7-1 Protein, Human, Recombinant (aa 35-242, His & Avi), Biotinylated	Human	HEK293 Cells
	Cluster of differentiation 80 (also CD80 and B7-1) is a protein found on dendritic cells, activated B cells and monocytes that provides a costimulatory signal necessary for T cell activation and survival. It is the ligan...
TMPK-00166	PD-L2 Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	PD-1 ligand 2 (PD-L2) as a second ligand for PD-1 and compare the function and expression of PD-L1 and PD-L2. Engagement of PD-1 by PD-L2 dramatically inhibits T cell receptor (TCR)-mediated proliferation and cytokine pr...
TMPK-00882	B7-2 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	B7-1 and B7-2 are homologous costimulatory ligands expressed on the surface of antigen presenting cells (APCs). Binding of these molecules to the T cell costimulatory receptors, CD28 and CTLA-4, is essential for the acti...
TMPK-01290	PD-L2 Protein, Cynomolgus, Recombinant (aa 20-220, His)	Cynomolgus	HEK293 Cells
	PD-1 ligand 2 (PD-L2) as a second ligand for PD-1 and compare the function and expression of PD-L1 and PD-L2. Engagement of PD-1 by PD-L2 dramatically inhibits T cell receptor (TCR)-mediated proliferation and cytokine pr...
TMPK-01066	BTLA Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	B- and T-lymphocyte attenuator (BTLA; CD272) is a 35 kDa type I transmembrane glycoprotein in the CD28 family of T cell costimulatory molecules. BTLA is a inhibitory receptor on lymphocytes that negatively regulates anti...
TMPK-00653	B7-2 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	B7-1 and B7-2 are homologous costimulatory ligands expressed on the surface of antigen presenting cells (APCs). Binding of these molecules to the T cell costimulatory receptors, CD28 and CTLA-4, is essential for the acti...
TMPK-00530	BTLA Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	B- and T-lymphocyte attenuator (BTLA; CD272) is a 35 kDa type I transmembrane glycoprotein in the CD28 family of T cell costimulatory molecules. BTLA is a inhibitory receptor on lymphocytes that negatively regulates anti...
TMPK-00880	B7-2 Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	B7-1 and B7-2 are homologous costimulatory ligands expressed on the surface of antigen presenting cells (APCs). Binding of these molecules to the T cell costimulatory receptors, CD28 and CTLA-4, is essential for the acti...
TMPK-00881	B7-2 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	B7-1 and B7-2 are homologous costimulatory ligands expressed on the surface of antigen presenting cells (APCs). Binding of these molecules to the T cell costimulatory receptors, CD28 and CTLA-4, is essential for the acti...
TMPJ-00629	TIGIT Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	T cell immunoreceptor with Ig and ITIM domains (TIGIT), also called VSIG9 and Vstm3, is a member of the CD28 family within the Ig superfamily of proteins. TIGIT contains an immunoglobulin variable domain, a transmembrane...
TMPJ-00181	PD-1 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell pr...