bace — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3161L	BACE-IN-1 acetate	BACE-IN-1 acetate (350228-37-4，Free base)	BACE
	BACE-IN-1 acetate (BACE-IN-1 acetate (350228-37-4，Free base)) has been used as β-site amyloid precursor protein (APP) cleaving enzyme-1 (BACE1) inhibitor in BACE1 inhibitor assay. β-Site amyloid precursor protein (APP) c...		BACE
T10449	BACE-1 inhibitor 1		Others
	BACE-1 inhibitor 1 (Compound 8a) is an effective BACE-1 inhibitor (IC50: 56 nM).		Others
T62181	BACE-IN-1
	BACE-IN-1 is an imidazo[1,2-a]pyridine derivative that inhibits the β-site amyloid precursor protein cleavage enzyme (BACE) sentence.BACE-IN-1 has the potential to investigate diseases involving BACE, such as Alzheimer's...
T62995	BACE-1 inhibitor 2
	BACE-1 Inhibitor 2 is a potent, CNS-permeable inhibitor of BACE-1, exhibiting an IC50 value of 1.5 nM in enzymatic assays [1].
T60691	AChE/BChE/BACE-1-IN-2
	AChE/BChE/BACE-1-IN-2 (Compound 4o) exhibits remarkable antioxidant potential and considerable binding capability towards PAS-AChE. AChE/BChE/BACE-1-IN-2 is an orally active AChE, BACE-1 and BChE inhibitor with IC 50 val...
T61206	AChE/BChE/BACE-1-IN-1
	AChE/BChE/BACE-1-IN-1 (Compound 4k) is an orally active inhibitor that targets acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and β-site amyloid precursor protein cleaving enzyme 1 (BACE-1). It displays IC50 ...
T11175	Elenbecestat	E2609	Beta-Secretase , BACE
	Elenbecestat (E2609) is an effective oral bioutilization and CNS penetrating ACE-1 inhibitor for the treatment of Alzheimer's disease.		Beta-Secretase , BACE
T5S2361	Epiberberine		ERK , Beta-Secretase , MEK , BACE , AMPK , AChR , AChE
	1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf/MEK1/ERK1/2 and AMPKα/Akt pathways during 3T3-L1 adipocyte diffe...		ERK , Beta-Secretase , MEK , BACE , AMPK , AChR , AChE
T3769	Tenuifolin		Others , Beta-Secretase , AChE
	Tenuifolin has no inherent toxicity to either the transfected or wild type cells at the effective concentrations, it inhibits amyloid-β secretion in vitro.		Others , Beta-Secretase , AChE
T12188	NB-360		BACE
	NB-360 is a potent and brain-penetrable inhibitor of BACE1 and BACE2 with IC50s of 5, 5, and 6 nM for mouse and human BACE1 and BACE2. NB-360 exhibits excellent selectivity over the related aspartyl proteases pepsin, cat...		BACE
T2639	LY2811376		Beta Amyloid , Beta-Secretase , BACE
	LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM). It has 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition...		Beta Amyloid , Beta-Secretase , BACE
T13253	Umibecestat	CNP520	BACE
	Umibecestat is an inhibitor of beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1), with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively. Umibecestat can be used for the research of al...		BACE
T8179	Aloeresin D		Beta-Secretase , BACE
	Aloeresin D, a natural chromone glycoside, inhibits β-Secretase (BACE1) activity (IC50: 39 μM).		Beta-Secretase , BACE
TN2190	Scoulerine		Apoptosis , Beta-Secretase , BACE , Parasite
	Scoulerine is an inhibitor of ß-site amyloid precursor protein cleaving enzyme 1(BACE1). Scoulerine a potent antimitotic compound that inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells.		Apoptosis , Beta-Secretase , BACE , Parasite
T6058	LY2886721		Beta-Secretase , BACE
	LY2886721, a BACE inhibitor, is used for the therapy of Alzheimer's Disease.		Beta-Secretase , BACE
T2S1181	Aloenin	Aloenin A,Aloearbonaside	Beta-Secretase , AChR
	1. Aloenin (Aloenin A) and aloe-emodin are active principles for inhibition of c-ADH and c-ALDH activities in vitro.		Beta-Secretase , AChR
T6772	AZD3839 free base	AZD3839	Beta-Secretase , BACE
	AZD3839 free base is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold selectivity over BACE2. Phase 1.		Beta-Secretase , BACE
T4398	LX2343		Beta Amyloid , Beta-Secretase , BACE , PI3K , Autophagy
	LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23 μM. LX2343 stimulates autophagy in its promotion of Aβ clearance.		Beta Amyloid , Beta-Secretase , BACE , PI3K , Autophagy
T7011	Verubecestat	MK-8931	Beta-Secretase , BACE
	Verubecestat (MK-8931) (MK-8931) is an effective and specific β-secretase inhibitor and β-site APP-cleaving enzyme 1 inhibitor or BACE1 protein inhibitor.		Beta-Secretase , BACE
T10451	BACE1-IN-2		BACE
	BACE1-IN-2 is a BACE1 inhibitor (IC50: 22 nM).		BACE