Powder: -20°C for 3 years
In solvent: -80°C for 2 years
NB-360 is a potent and brain-penetrable inhibitor of <a href="/target/BACE" style="display: inline; color: #c13a36">BACE</a>1 and <a href="/target/BACE" style="display: inline; color: #c13a36">BACE</a>2 with IC50s of 5, 5, and 6 nM for mouse and human <a href="/target/BACE" style="display: inline; color: #c13a36">BACE</a>1 and <a href="/target/BACE" style="display: inline; color: #c13a36">BACE</a>2. NB-360 exhibits excellent selectivity over the related aspartyl proteases pepsin, cathepsin E, and cathepsin D.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 237.00 | |
5 mg | In stock | $ 437.00 | |
10 mg | In stock | $ 725.00 | |
25 mg | In stock | $ 1,487.00 | |
50 mg | In stock | $ 2,345.00 |
Description | NB-360 is a potent and brain-penetrable inhibitor of BACE1 and BACE2 with IC50s of 5, 5, and 6 nM for mouse and human BACE1 and BACE2. NB-360 exhibits excellent selectivity over the related aspartyl proteases pepsin, cathepsin E, and cathepsin D. |
Targets&IC50 | Mouse , human BACE1:5 nM , BACE2:6 nM |
In vivo | NB-360 blocks the progression of Aβ deposition in the brains of APP transgenic mice, a model for amyloid pathology. Almost complete reduction of Aβ was achieved also in rats and in dogs. NB-360 stops accumulation of activated inflammatory cells in the brains of APP transgenic mice. Upon chronic treatment of APP transgenic mice, patches of grey hairs appeared[2]. |
Molecular Weight | 449.4 |
Formula | C21H19F4N5O2 |
CAS No. | 1262857-73-7 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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NB-360 1262857-73-7 Neuroscience BACE Inhibitor NB 360 β-Secretase inhibit NB360 Beta-secretase inhibitor