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NB-360

Catalog No. T12188 CAS 1262857-73-7

NB-360 is a potent and brain-penetrable inhibitor of BACE1 and BACE2 with IC50s of 5, 5, and 6 nM for mouse and human BACE1 and BACE2. NB-360 exhibits excellent selectivity over the related aspartyl proteases pepsin, cathepsin E, and cathepsin D.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

NB-360, CAS 1262857-73-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 187.00
5 mg	In stock	$ 397.00
10 mg	In stock	$ 589.00
25 mg	In stock	$ 945.00
50 mg	In stock	$ 1,280.00
100 mg	In stock	$ 1,730.00
500 mg	In stock	$ 3,460.00
1 mL * 10 mM (in DMSO)	In stock	$ 437.00

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Purity: 99.25%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	NB-360 is a potent and brain-penetrable inhibitor of BACE1 and BACE2 with IC50s of 5, 5, and 6 nM for mouse and human BACE1 and BACE2. NB-360 exhibits excellent selectivity over the related aspartyl proteases pepsin, cathepsin E, and cathepsin D.
Targets&IC50	BACE2:6 nM , Mouse , human BACE1:5 nM
In vivo	NB-360 blocks the progression of Aβ deposition in the brains of APP transgenic mice, a model for amyloid pathology. Almost complete reduction of Aβ was achieved also in rats and in dogs. NB-360 stops accumulation of activated inflammatory cells in the brains of APP transgenic mice. Upon chronic treatment of APP transgenic mice, patches of grey hairs appeared[2].

Molecular Weight	449.4
Formula	C21H19F4N5O2
CAS No.	1262857-73-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 45 mg/mL (100.13 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Neumann U, et al. Mol Neurodegener. 2015 Sep 3;10:44. doi: 10.1186/s13024-015-0033-8. 2. Neumann U, et al. The β-secretase (BACE) inhibitor NB-360 in preclinical models: From amyloid-β reduction to downstream disease-relevant effects. Br J Pharmacol. 2019 Sep;176(18):3435-3446.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Bioactive Compounds Library Max Inhibitor Library Neuronal Signaling Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

NB-360 1262857-73-7 Neuroscience BACE Inhibitor NB 360 β-Secretase inhibit NB360 Beta-secretase inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.