Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Verubecestat (MK-8931) is an effective and specific β-secretase inhibitor and β-site APP-cleaving enzyme 1 inhibitor or BACE1 protein inhibitor.
Description | Verubecestat (MK-8931) is an effective and specific β-secretase inhibitor and β-site APP-cleaving enzyme 1 inhibitor or BACE1 protein inhibitor. |
Targets&IC50 | BACE1:1.75 nM(Ki), BACE2:0.37 nM(Ki) |
In vitro | Verubecestat(MK-8931) effectively reduces Aβ40 in cells with a Ki of 7.8 nM and an IC50 of 13 nM[2]. |
In vivo | Verubecestat(MK-8931) dramatically lowers CSF and cortex Aβ40 in both rats and cynomolgus monkeys following a single oral dose. Due to the 20 h half-life of MK-8931 it is ideal for once-a-day dosing[2]. |
Synonyms | 维罗司他, MK-8931 |
Molecular Weight | 409.41 |
Formula | C17H17F2N5O3S |
CAS No. | 1286770-55-5 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
H2O: <1 mg/mL
Ethanol: 5 mg/mL (9.55 mM)
DMSO: 81 mg/mL (154.74 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Verubecestat 1286770-55-5 神经科学 BACE Beta-Secretase orally Beta-secretase β-Secretase inhibit Aβ40 MK-8931 BACE1 MK8931 Alzheimer's Inhibitor MK 8931 Disease BACE2 inhibitor