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Verubecestat

Catalog No. T7011 CAS 1286770-55-5

Synonyms: 维罗司他, MK-8931

Verubecestat (MK-8931) is an effective and specific β-secretase inhibitor and β-site APP-cleaving enzyme 1 inhibitor or BACE1 protein inhibitor.

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Verubecestat, CAS 1286770-55-5

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Verubecestat (MK-8931) is an effective and specific β-secretase inhibitor and β-site APP-cleaving enzyme 1 inhibitor or BACE1 protein inhibitor.
Targets&IC50	BACE1:1.75 nM(Ki), BACE2:0.37 nM(Ki)
In vitro	Verubecestat(MK-8931) effectively reduces Aβ40 in cells with a Ki of 7.8 nM and an IC50 of 13 nM[2].
In vivo	Verubecestat(MK-8931) dramatically lowers CSF and cortex Aβ40 in both rats and cynomolgus monkeys following a single oral dose. Due to the 20 h half-life of MK-8931 it is ideal for once-a-day dosing[2].

Synonyms	维罗司他, MK-8931
Molecular Weight	409.41
Formula	C17H17F2N5O3S
CAS No.	1286770-55-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: <1 mg/mL

Ethanol: 5 mg/mL (9.55 mM)

DMSO: 81 mg/mL (154.74 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Evin G, et al. BioDrugs. 2016, 30(3):173-94. 2. Yan R, et al. Transl Neurodegener. 2016, 5:13.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Anti-Cardiovascular Disease Compound Library Inhibitor Library Anti-Alzheimer's Disease Compound Library Fluorochemical Library Drug Repurposing Compound Library Ferroptosis Compound Library Neuronal Signaling Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library

Related Products

Related compounds with same targets

Lanabecestat Putraflavone Kushenol C Anatabine Bavachromene Epiberberine chloride PF-06751979 BACE1-IN-5

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Verubecestat 1286770-55-5 神经科学 BACE Beta-Secretase orally Beta-secretase β-Secretase inhibit Aβ40 MK-8931 BACE1 MK8931 Alzheimer's Inhibitor MK 8931 Disease BACE2 inhibitor

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