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Verubecestat

Catalog No. T7011 CAS 1286770-55-5

Synonyms: MK-8931

Verubecestat (MK-8931) (MK-8931) is an effective and specific β-secretase inhibitor and β-site APP-cleaving enzyme 1 inhibitor or BACE1 protein inhibitor.

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Verubecestat, CAS 1286770-55-5

Pack Size	Availability	Price/USD
2 mg	In stock	$ 34.00
5 mg	In stock	$ 55.00
10 mg	In stock	$ 80.00
25 mg	In stock	$ 155.00
50 mg	In stock	$ 228.00
100 mg	In stock	$ 372.00
500 mg	In stock	$ 869.00
1 mL * 10 mM (in DMSO)	In stock	$ 61.00

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Purity: 99.49%

Purity: 92.24%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Verubecestat (MK-8931) (MK-8931) is an effective and specific β-secretase inhibitor and β-site APP-cleaving enzyme 1 inhibitor or BACE1 protein inhibitor.
Targets&IC50	BACE1:1.75 nM(Ki), BACE2:0.37 nM(Ki)
In vitro	Verubecestat(MK-8931) effectively reduces Aβ40 in cells with a Ki of 7.8 nM and an IC50 of 13 nM[2].
In vivo	Verubecestat(MK-8931) dramatically lowers CSF and cortex Aβ40 in both rats and cynomolgus monkeys following a single oral dose. Due to the 20 h half-life of MK-8931 it is ideal for once-a-day dosing[2].

Synonyms	MK-8931
Molecular Weight	409.41
Formula	C17H17F2N5O3S
CAS No.	1286770-55-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 5 mg/mL (9.55 mM)

DMSO: 81 mg/mL (154.74 mM)

References and Literature

1. Evin G, et al. BioDrugs. 2016, 30(3):173-94. 2. Yan R, et al. Transl Neurodegener. 2016, 5:13.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Neurodegenerative Disease Compound Library Inhibitor Library Anti-Alzheimer's Disease Compound Library Neuronal Signaling Compound Library Ferroptosis Compound Library Bioactive Compounds Library Max Fluorochemical Library Anti-Hypertension Compound Library Anti-Cardiovascular Disease Compound Library

Related Products

Related compounds with same targets

BACE1-IN-10 Se-Methylselenocysteine hydrochloride β-Secretase inhibitor-STA LY2811376 Epiberberine chloride AZD3839 free base LY2886721 Eslicarbazepine

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Verubecestat 1286770-55-5 Neuroscience Beta-Secretase BACE MK-8931 orally Beta-secretase β-Secretase inhibit Aβ40 BACE1 Alzheimer's Inhibitor MK 8931 Disease BACE2 MK8931 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.