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LY2886721

Catalog No. T6058 CAS 1262036-50-9

LY2886721, a BACE inhibitor, is used for the therapy of Alzheimer's Disease.

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LY2886721, CAS 1262036-50-9

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Purity: 98%

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Description	LY2886721, a BACE inhibitor, is used for the therapy of Alzheimer's Disease.
Targets&IC50	BACE2:10.2 nM, BACE1:20.3 nM
In vitro	LY2886721 is an oral, small molecule of β-site amyloid protein cleaving enzyme (BACE) inhibitor with the potential to inhibit the synthesis of β-amyloid and thereby to slow the Clinicalal progression of AD. [1] LY2886721 can also targetγ-secretase to nhibit the synthesis of β-amyloid. [2]
Kinase Assay	The CTLs and NK cells (0.8×106/mL) are treated with the inhibitors L1 (10-20 μM) or Aloxistatin (20-30 μM) for 24 hr at 37°C in 24-well plates. Cells are then used in 51Cr-release assays or are lysed to examine perforin in Western blots. The inhibitor is also added at the same concentration during the 4 hr reactions in some 51Cr-release assays, as indicated. Cell lysates are prepared using NP-40 lysis buffer (25 mM HEPES, 250 mM NaCl, 2.5 mM ethylenediaminetetraacetic acid, 0.1% volume/volume Nonidet P-40) and total protein concentration is determined using the Bradford assay. Equal amounts of protein are loaded and resolved on 8% SDS-PAGE gels. Human or mouse perforin is detected using the appropriate antibodies as indicated. Anti-actin antibody is used as a loading control[2].

Molecular Weight	390.41
Formula	C18H16F2N4O2S
CAS No.	1262036-50-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

Ethanol: <1 mg/mL

H2O: <1 mg/mL

DMSO: 9 mg/mL (23.05 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

2. Townsend M, et al. J Alzheimers Dis, 2011, 24 Suppl 2, 43-52.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Anti-Cardiovascular Disease Compound Library Inhibitor Library Anti-Alzheimer's Disease Compound Library Fluorochemical Library Drug Repurposing Compound Library Neuronal Signaling Compound Library CNS-Penetrant Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library

Related Products

Related compounds with same targets

Lanabecestat Putraflavone Kushenol C Anatabine Bavachromene Epiberberine chloride PF-06751979 BACE1-IN-5

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Keywords

LY2886721 1262036-50-9 神经科学 BACE Beta-Secretase BACE2 Inhibitor Beta-secretase LY 2886721 LY-2886721 BBB Alzheimer's BACE1 sAPPβ C99 inhibit disease β-Secretase inhibitor

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