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LY2886721

Catalog No. T6058 CAS 1262036-50-9

LY2886721, a BACE inhibitor, is used for the therapy of Alzheimer's Disease.

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LY2886721, CAS 1262036-50-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 31.00
2 mg	In stock	$ 44.00
5 mg	In stock	$ 72.00
10 mg	In stock	$ 122.00
25 mg	In stock	$ 235.00
50 mg	In stock	$ 413.00
100 mg	In stock	$ 615.00
1 mL * 10 mM (in DMSO)	In stock	$ 79.00

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Purity: 99.94%

Purity: 99.45%

Purity: 99%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	LY2886721, a BACE inhibitor, is used for the therapy of Alzheimer's Disease.
Targets&IC50	BACE1:20.3 nM, BACE2:10.2 nM
In vitro	LY2886721 is an oral, small molecule of β-site amyloid protein cleaving enzyme (BACE) inhibitor with the potential to inhibit the synthesis of β-amyloid and thereby to slow the Clinicalal progression of AD. [1] LY2886721 can also targetγ-secretase to nhibit the synthesis of β-amyloid. [2]
Kinase Assay	The CTLs and NK cells (0.8×106/mL) are treated with the inhibitors L1 (10-20 μM) or Aloxistatin (20-30 μM) for 24 hr at 37°C in 24-well plates. Cells are then used in 51Cr-release assays or are lysed to examine perforin in Western blots. The inhibitor is also added at the same concentration during the 4 hr reactions in some 51Cr-release assays, as indicated. Cell lysates are prepared using NP-40 lysis buffer (25 mM HEPES, 250 mM NaCl, 2.5 mM ethylenediaminetetraacetic acid, 0.1% volume/volume Nonidet P-40) and total protein concentration is determined using the Bradford assay. Equal amounts of protein are loaded and resolved on 8% SDS-PAGE gels. Human or mouse perforin is detected using the appropriate antibodies as indicated. Anti-actin antibody is used as a loading control[2].

Molecular Weight	390.41
Formula	C18H16F2N4O2S
CAS No.	1262036-50-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 9 mg/mL (23.05 mM)

References and Literature

2. Townsend M, et al. J Alzheimers Dis, 2011, 24 Suppl 2, 43-52.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library Anti-Neurodegenerative Disease Compound Library Anti-Aging Compound Library Covalent Inhibitor Library Protease Inhibitor Library Orally Active Compound Library NO PAINS Compound Library Anti-Hypertension Compound Library ReFRAME Related Library

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BACE1-IN-10 Elenbecestat LX2343 LY2811376 Sophoflavescenol AZD3839 free base Eslicarbazepine Verubecestat

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Keywords

LY2886721 1262036-50-9 Neuroscience Beta-Secretase BACE BACE2 Inhibitor Beta-secretase BBB Alzheimer's BACE1 sAPPβ LY 2886721 C99 LY-2886721 inhibit disease β-Secretase inhibitor

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