Umibecestat

Umibecestat is an inhibitor of beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1), with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively. Umibecestat can be used for the research of alzheimer's disease.

Catalog No. T13253Cas No. 1387560-01-1

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Purity:100%

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COA HNMR HPLC

Umibecestat

Catalog No. T13253Cas No. 1387560-01-1

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Pack Size	Price	Availability
1 mg	$175	In Stock
5 mg	$372	In Stock
10 mg	$538	In Stock
25 mg	$896	In Stock
50 mg	$1,220	In Stock
100 mg	$1,650	In Stock
1 mL x 10 mM (in DMSO)	$455	In Stock

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Product Introduction

Bioactivity

Description	Umibecestat is an inhibitor of beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1), with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively. Umibecestat can be used for the research of alzheimer's disease.
Targets&IC50	BACE1 (mouse):10 nM , BACE1 (human):11 nM
In vitro	Umibecestat is a potent inhibitor of BACE-1 that is selective for BACE-1 over other human pepsin-like aspartic proteases, including BACE-2 and cathepsin D[1].
In vivo	In both rat brain and CSF, Umibecestat (CNP520) (1.5-51.3 mg/kg; given by oral gavage; 72 hours) shows dose-dependent effects on Aβ40 and a long duration of action. Umibecestat (3.1 mg/kg; p.o.; 7 days) shows a > 75% reduction on Aβ40 and Aβ42 in CSF after dosing and returns slowly to baseline over the next 7 days[1].
Alias	CNP520

Chemical Properties

Molecular Weight	513.8
Formula	C₁₉H₁₅ClF₇N₅O₂
Cas No.	1387560-01-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 95 mg/mL (184.90 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9463 mL	9.7314 mL	19.4628 mL	97.3141 mL
5 mM	0.3893 mL	1.9463 mL	3.8926 mL	19.4628 mL
10 mM	0.1946 mL	0.9731 mL	1.9463 mL	9.7314 mL
20 mM	0.0973 mL	0.4866 mL	0.9731 mL	4.8657 mL
50 mM	0.0389 mL	0.1946 mL	0.3893 mL	1.9463 mL
100 mM	0.0195 mL	0.0973 mL	0.1946 mL	0.9731 mL

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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