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Umibecestat

Umibecestat
Umibecestat is an inhibitor of beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1), with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively. Umibecestat can be used for the research of alzheimer's disease.
Catalog No. T13253Cas No. 1387560-01-1
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Umibecestat

Catalog No. T13253Cas No. 1387560-01-1
Umibecestat is an inhibitor of beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1), with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively. Umibecestat can be used for the research of alzheimer's disease.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$175In Stock
5 mg$372In Stock
10 mg$538In Stock
25 mg$896In Stock
50 mg$1,220In Stock
100 mg$1,650In Stock
1 mL x 10 mM (in DMSO)$455In Stock
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Product Introduction

Bioactivity
Description
Umibecestat is an inhibitor of beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1), with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively. Umibecestat can be used for the research of alzheimer's disease.
Targets&IC50
BACE1 (mouse):10 nM , BACE1 (human):11 nM
In vitro
Umibecestat is a potent inhibitor of BACE-1 that is selective for BACE-1 over other human pepsin-like aspartic proteases, including BACE-2 and cathepsin D[1].
In vivo
In both rat brain and CSF, Umibecestat (CNP520) (1.5-51.3 mg/kg; given by oral gavage; 72 hours) shows dose-dependent effects on Aβ40 and a long duration of action. Umibecestat (3.1 mg/kg; p.o.; 7 days) shows a > 75% reduction on Aβ40 and Aβ42 in CSF after dosing and returns slowly to baseline over the next 7 days[1].
AliasCNP520
Chemical Properties
Molecular Weight513.8
FormulaC19H15ClF7N5O2
Cas No.1387560-01-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 95 mg/mL (184.90 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9463 mL9.7314 mL19.4628 mL97.3141 mL
5 mM0.3893 mL1.9463 mL3.8926 mL19.4628 mL
10 mM0.1946 mL0.9731 mL1.9463 mL9.7314 mL
20 mM0.0973 mL0.4866 mL0.9731 mL4.8657 mL
50 mM0.0389 mL0.1946 mL0.3893 mL1.9463 mL
100 mM0.0195 mL0.0973 mL0.1946 mL0.9731 mL

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