b16f10 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TN6901	Methyl myristate	methyl tetradecanoate	Others
	Methyl myristate (methyl tetradecanoate) is a natural product.		Others
T1992	Mertansine	DM1,Maytansinoid DM1	Microtubule Associated
	Mertansine (DM1) refers to the thiol-containing maytansinoid, DM1 (N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through reaction of the thiol group with the SPP (N-succinimidyl 4...		Microtubule Associated
T22136	PRL-3 Inhibitor I	PRL-3 Inhibitor,BR-1	Phosphatase , Others
	PRL-3 Inhibitor I (BR-1) is a phosphatase of regenerating liver 3 (PRL-3) inhibitor which blocks the migration and invasion of metastatic cancer cells.		Phosphatase , Others
T2586	Cabozantinib	XL184,BMS-907351	Apoptosis , VEGFR , FLT , c-Met/HGFR , c-RET , TAM Receptor , c-Kit
	Cabozantinib (XL184) is a multi-targeted tyrosine kinase receptor inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt3 (IC50=0.035/1.3/4.6/7/11.3 nM). Cabozantinib exhibits both antitumor and antiangiogenic activity...
T5164	Cabozantinib hydrochloride	XL184,Cabozantinib hydrochloride (849217-68-1(free base)),BMS-907351	VEGFR , FLT , c-Met/HGFR , TAM Receptor , c-Kit , ROR
	Cabozantinib hydrochloride (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6 nM).		VEGFR , FLT , c-Met/HGFR , TAM Receptor , c-Kit , ROR
TMA0958	Forsythoside F	Arenarioside	Xanthine Oxidase
	Forsythoside F (Arenarioside) is a natural product, and GI50 values of 10-16 microM against B16F10 cell.		Xanthine Oxidase
TN6972	Methyl pentadecanoate		Others
	Methyl pentadecanoate is a natural product.		Others
T77743	TT-012		Others
	TT-012 has anti-tumor activity, selectively binds dynamic MITF and disrupts the dimer formation and DNA binding of the latter. TT-012 can inhibit the transcription of MITF in B16F10 melanoma cells. TT-012 inhibited the g...		Others
T0938	Thiabendazole	2-(4-Thiazolyl)benzimidazole	Microtubule Associated , Mitochondrial Metabolism , Parasite
	Thiabendazole (2-(4-Thiazolyl)benzimidazole) is a benzimidazole derivative with anthelminthic property.
TN5300	Citrostadienol
	Citrostadienol shows cytotoxic activity against B16F10 melanoma cells.
TN3605	Casegravol		Others
	Casegravol shows antiproliferative activity against human gastric adenocarcinoma (MK-1), human uterus carcinoma (HeLa), and murine melanoma (B16F10) cells.		Others
TN5086	Syringetin		Others
	Syringetin, a flavonoid derivative found in grapes and wine, promotes melanogenesis in B16F10 cells and inhibits osteoblast-mediated osteoclastogenesis in human lung adenocarcinoma.		Others
T28522	Reticulol
	Reticulol is an isocoumarin derivative produced by certain species of Streptomyces. Reticulol inhibits cAMP phosphodiesterase (IC50 = 41 µM). Recticulol (M.W. 222.2) exhibits a potent in vitro cytotoxicity against the hu...
TN3644	Chlorophorin		Tyrosinase , Antifection
	Chlorophorin shows high anti-protozoal activity with an MIC of 0.25 microg/ml. Chlorophorin can strongly inhibit mushroom tyrosinase activity with IC50 values of 2.5 ± 0.408 uM; it inhibits α-melanocyte-stimulating hormo...		Tyrosinase , Antifection
T69447	APBC
	APBC is a novel PD-L1 inhibitor, effectively interrupting the PD-1/PD-L1 interaction by directly binding to PD-L1, presenting the KD and IC50 values at low-micromolar level, displaying superior antitumor efficacy in hPD-...
TN5477	GB-2a
	GB 2a shows antioxidant and anti-inflammatory effects, it can prevent the carrageenan-induced paw oedema. GB 2a biflavonoid can promote inhibition on tyrosinase activity and reduced melanin biosynthesis in B16F10 cells, ...
T79401	Tyrosinase-IN-13		Tyrosinase
	Tyrosinase-IN-13 (compound 3c), stemming from Flurbiprofen, acts as a potent non-competitive inhibitor of tyrosinase, exhibiting IC50 and Ki values of 68 μM and 36.3 μM respectively. This compound demonstrates cytotoxici...		Tyrosinase
T76072L	CCZ01048 TFA
	CCZ01048 TFA, an α-MSH analogue, demonstrates a strong binding affinity for the melanocortin 1 receptor (MC1R), displaying a K i value of 0.31 nM. It exhibits rapid internalization into B16F10 melanoma cells and maintain...
T75554	6-O-Isobutyrylbritannilactone
	6-O-Isobutyrylbritannilactone, a sesquiterpene natural melanogenesis inhibitor, can be extracted from Inula britannica flowers. It effectively suppresses IBMX-induced melanin production in B16F10 cells and exerts antimel...
T82524	Dual photoCORM 1
	Dual photoCORM 1 (compound 5), a metal-free, photoactive, dual carbon monoxide releasing molecule (CORM), demonstrates efficient cellular uptake and enables real-time tracking of CO release via a colorimetric change in B...