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Catalog No. T0938   CAS 148-79-8
Synonyms: 2-(4-Thiazolyl)benzimidazole

Thiabendazole is a benzimidazole derivative with anthelminthic property.

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Thiabendazole, CAS 148-79-8
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Thiabendazole is a benzimidazole derivative with anthelminthic property.
Targets&IC50 and B16F10 proliferation in vitro 72 h:238.5 +/- 19.8 microM, B16F10 proliferation in vitro 24 h:532.4 +/- 32.6 microM, B16F10 proliferation in vitro 48 h:322.9 +/- 28.9 microM
In vitro Thiabendazole provokes a strong DNA-damaging activity in the human lymphoblastoid cell line that constitutively expresses human CYP1A1 cDNA, but not in the parental line, indicating that CYP1A1 is chiefly implicated in carbaryl and thiabendazole genotoxicity. [1] Thiabendazole provokes a dose- and time-dependent increase in CYP1A1 (EROD activity, protein and mRNA levels) in primary culture of rat hepatocytes. [2] Thiabendazole results in the induction of 7-ethoxyresorufin O-deethylase and 7-pentoxyresorufin O-depentylase activities, CYP1A1, CYP1A2, CYP2B1 and CYP2B1/2 mRNA levels and CYP1A2 and CYP2B1/2 apoprotein levels. Thiabendazole markedly induces GSTP1 mRNA levels, but has only a small effect on GSTT1 mRNA levels. [3] Thiabendazole is rapidly transported by passive diffusion through the human intestinal cells by comparison with the protein-bound residues which are not able to cross the intestinal barrier. Thiabendazole will be firstly metabolized to 5OH-TBZ and subsequently converted to a chemically reactive metabolic intermediate binding to proteins. [4]
In vivo Thiabendazole results in nephrosis or hydronephrosis and this organ toxicity may lead to the high dose-dependent mortality in treated mice. Thiabendazole results in hormone imbalance and this imbalance may play an important role in the changes of the reproductive or endocrine system in treated mice. [5]
Synonyms 2-(4-Thiazolyl)benzimidazole
Molecular Weight 201.25
Formula C10H7N3S
CAS No. 148-79-8


Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: <1 mg/mL

Ethanol: 1 mg/mL (4.96 mM)

DMSO: 38 mg/mL (188.8 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Delescluse C, et al. Biochem Pharmacol, 2001, 61(4), 399-407. 2. Lemaire G, et al. Life Sci, 2004, 74(18), 2265-2278. 3. Price RJ, et al. Food Chem Toxicol, 2004, 42(6), 899-908. 4. Coulet M, et al. Chem Biol Interact, 2000, 127(2), 109-124. 5. Tada Y, et al. Toxicology, 2001, 169(3), 163-176.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box


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Thiabendazole 148-79-8 Cytoskeletal Signaling Metabolism Microbiology/Virology Mitochondrial Metabolism Parasite Microtubule Associated 2-(4-Thiazolyl)benzimidazole inhibit Inhibitor inhibitor