Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Thiabendazole is a benzimidazole derivative with anthelminthic property.
Description | Thiabendazole is a benzimidazole derivative with anthelminthic property. |
Targets&IC50 | and B16F10 proliferation in vitro 72 h:238.5 +/- 19.8 microM, B16F10 proliferation in vitro 24 h:532.4 +/- 32.6 microM, B16F10 proliferation in vitro 48 h:322.9 +/- 28.9 microM |
In vitro | Thiabendazole provokes a strong DNA-damaging activity in the human lymphoblastoid cell line that constitutively expresses human CYP1A1 cDNA, but not in the parental line, indicating that CYP1A1 is chiefly implicated in carbaryl and thiabendazole genotoxicity. [1] Thiabendazole provokes a dose- and time-dependent increase in CYP1A1 (EROD activity, protein and mRNA levels) in primary culture of rat hepatocytes. [2] Thiabendazole results in the induction of 7-ethoxyresorufin O-deethylase and 7-pentoxyresorufin O-depentylase activities, CYP1A1, CYP1A2, CYP2B1 and CYP2B1/2 mRNA levels and CYP1A2 and CYP2B1/2 apoprotein levels. Thiabendazole markedly induces GSTP1 mRNA levels, but has only a small effect on GSTT1 mRNA levels. [3] Thiabendazole is rapidly transported by passive diffusion through the human intestinal cells by comparison with the protein-bound residues which are not able to cross the intestinal barrier. Thiabendazole will be firstly metabolized to 5OH-TBZ and subsequently converted to a chemically reactive metabolic intermediate binding to proteins. [4] |
In vivo | Thiabendazole results in nephrosis or hydronephrosis and this organ toxicity may lead to the high dose-dependent mortality in treated mice. Thiabendazole results in hormone imbalance and this imbalance may play an important role in the changes of the reproductive or endocrine system in treated mice. [5] |
Synonyms | 2-(4-Thiazolyl)benzimidazole |
Molecular Weight | 201.25 |
Formula | C10H7N3S |
CAS No. | 148-79-8 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
H2O: <1 mg/mL
Ethanol: 1 mg/mL (4.96 mM)
DMSO: 38 mg/mL (188.8 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Thiabendazole 148-79-8 Cytoskeletal Signaling Metabolism Microbiology/Virology Mitochondrial Metabolism Parasite Microtubule Associated 2-(4-Thiazolyl)benzimidazole inhibit Inhibitor inhibitor