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Thiabendazole

Catalog No. T0938 CAS 148-79-8

Synonyms: 2-(4-Thiazolyl)benzimidazole

Thiabendazole is a benzimidazole derivative with anthelminthic property.

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Thiabendazole, CAS 148-79-8

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Thiabendazole is a benzimidazole derivative with anthelminthic property.
Targets&IC50	and B16F10 proliferation in vitro 72 h:238.5 +/- 19.8 microM, B16F10 proliferation in vitro 24 h:532.4 +/- 32.6 microM, B16F10 proliferation in vitro 48 h:322.9 +/- 28.9 microM
In vitro	Thiabendazole provokes a strong DNA-damaging activity in the human lymphoblastoid cell line that constitutively expresses human CYP1A1 cDNA, but not in the parental line, indicating that CYP1A1 is chiefly implicated in carbaryl and thiabendazole genotoxicity. [1] Thiabendazole provokes a dose- and time-dependent increase in CYP1A1 (EROD activity, protein and mRNA levels) in primary culture of rat hepatocytes. [2] Thiabendazole results in the induction of 7-ethoxyresorufin O-deethylase and 7-pentoxyresorufin O-depentylase activities, CYP1A1, CYP1A2, CYP2B1 and CYP2B1/2 mRNA levels and CYP1A2 and CYP2B1/2 apoprotein levels. Thiabendazole markedly induces GSTP1 mRNA levels, but has only a small effect on GSTT1 mRNA levels. [3] Thiabendazole is rapidly transported by passive diffusion through the human intestinal cells by comparison with the protein-bound residues which are not able to cross the intestinal barrier. Thiabendazole will be firstly metabolized to 5OH-TBZ and subsequently converted to a chemically reactive metabolic intermediate binding to proteins. [4]
In vivo	Thiabendazole results in nephrosis or hydronephrosis and this organ toxicity may lead to the high dose-dependent mortality in treated mice. Thiabendazole results in hormone imbalance and this imbalance may play an important role in the changes of the reproductive or endocrine system in treated mice. [5]

Synonyms	2-(4-Thiazolyl)benzimidazole
Molecular Weight	201.25
Formula	C10H7N3S
CAS No.	148-79-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: <1 mg/mL

Ethanol: 1 mg/mL (4.96 mM)

DMSO: 38 mg/mL (188.8 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Delescluse C, et al. Biochem Pharmacol, 2001, 61(4), 399-407. 2. Lemaire G, et al. Life Sci, 2004, 74(18), 2265-2278. 3. Price RJ, et al. Food Chem Toxicol, 2004, 42(6), 899-908. 4. Coulet M, et al. Chem Biol Interact, 2000, 127(2), 109-124. 5. Tada Y, et al. Toxicology, 2001, 169(3), 163-176.

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You can also refer to dose conversion for different animals. More

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Thiabendazole 148-79-8 Cytoskeletal Signaling Metabolism Microbiology/Virology Mitochondrial Metabolism Parasite Microtubule Associated 2-(4-Thiazolyl)benzimidazole inhibit Inhibitor inhibitor

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