atm/atr — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3032	VE-821	ATR Inhibitor IV	ATM/ATR
	VE-821 (ATR Inhibitor IV) is a selective ATP competitive inhibitor of ATR( Ki/IC50: 13/26 nM in cell-free assays).		ATM/ATR
T5175	Azd1390		ATM/ATR
	AZD1390 is an exceptionally potent inhibitor of ATM in cells (IC50: 0.78 nM) with >10,000-fold selectivity over closely related members of the PIKK family of enzymes.		ATM/ATR
T6612	NU6027		ATM/ATR , DNA-PK , CDK
	NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurine-based inhibitors.		ATM/ATR , DNA-PK , CDK
T2685	KU-55933	ATM Kinase Inhibitor	ATM/ATR , DNA-PK , PI3K , mTOR , Autophagy
	KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor.		ATM/ATR , DNA-PK , PI3K , mTOR , Autophagy
T3338	Ceralasertib	AZD6738	ATM/ATR
	Ceralasertib (AZD6738) is an orally active, and selective ATR kinase inhibitor with IC50 of 1 nM.		ATM/ATR
T1958	AZ20		ATM/ATR , mTOR
	AZ20 is an effective and specific inhibitor of ATR kinase (IC50: 5 nM, in a cell-free assay), 8-fold selectivity over mTOR.		ATM/ATR , mTOR
T4443	AZ32		ATM/ATR
	AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell.		ATM/ATR
T6770	AZD0156		Apoptosis , ATM/ATR
	AZD0156 , an effective and specific inhibitors of ATM kinase, is potential antineoplastic activities and chemo-/radio-sensitizing.		Apoptosis , ATM/ATR
T1821	CGK733	CGK 733	ATM/ATR
	CGK733 (CGK 733) is a potent and selective inhibitor of ATM/ATR.		ATM/ATR
T6261	CP-466722	CP 466722,CP466722	ATM/ATR
	CP-466722, an effective and reversible ATM inhibitor, does not inhibit ATR and PI3K or PIKK family members in cells.		ATM/ATR
T2084	ETP-46464		ATM/ATR , DNA-PK , PI3K , mTOR
	ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).		ATM/ATR , DNA-PK , PI3K , mTOR
TN1673	Garcinone C		ATM/ATR , CDK , STAT , AChR , Antifection
	Garcinone C is a xanthone derivative extracted from Garcinia oblongifolia Champ with anti-inflammatory, astringency, and granulation-promoting activities. Garcinone C is an AChE inhibitor and has potential cytotoxic effe...		ATM/ATR , CDK , STAT , AChR , Antifection
T7318	Elimusertib	BAY-1895344	ATM/ATR
	Elimusertib (BAY-1895344) is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.Elimusertib shows potent anti-tumor efficacy in monotherapy and strong combination potential with the target...		ATM/ATR
T1923	BRD4770		Histone Methyltransferase
	BRD4770 is a histone methyltransferase G9a inhibitor and induces cell senescence.		Histone Methyltransferase
T7122	AZD-7648		DNA-PK
	AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.		DNA-PK
T6100	Torin 2		Apoptosis , ATM/ATR , DNA-PK , mTOR , Autophagy
	Torin 2(IC50=0.25 nM), a specific and effective mTOR inhibitor, is the 800-fold greater specific activity for mTOR than PI3K and improves pharmacokinetic properties. The EC50 of Torin 2 for ATM/ATR/DNA-PK inhibition is 2...		Apoptosis , ATM/ATR , DNA-PK , mTOR , Autophagy
T19671	AZ31	AZ 31,AZ-31	ATM/ATR
	AZ31 is an ATM inhibitor with potency, high selectivity, and oral activity.AZ31 inhibits ATM enzymes, intracellular ATM, with IC50 values of <1.2 nM and 46 nM, respectively.AZ31 exhibits excellent ATR selectivity, PIKK f...		ATM/ATR
T62083	Camonsertib	ATR inhibitor 4,RP-3500	ATM/ATR
	Camonsertib (RP-3500) is a selective, orally active ATR kinase inhibitor (ATRi) with an IC50: 1.00 nM in biochemical assays and exhibits potent antitumour effects. Camonsertib is 30 times more selective for ATR than mTOR...		ATM/ATR
T2433	NU 7026	NU7026,DNA-PK Inhibitor II,LY293646	Apoptosis , ATM/ATR , DNA-PK , PI3K
	NU 7026 (DNA-PK Inhibitor II) is an effective DNA-PK inhibitor (IC50: 0.23 μM, in cell-free assays), 60-fold selective for DNA-PK than PI3K and no inhibition against both ATM and ATR.		Apoptosis , ATM/ATR , DNA-PK , PI3K
T68845	Americanin A
	Americanin A natural thrombin inhibitor, suppressing melanin synthesis, regulating the ATM/ATR signaling pathway and the Skp2-p27 axis in human colon cancer cells.