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AZ31

Catalog No. T19671 CAS 2088113-98-6

Synonyms: AZ 31, AZ-31

AZ31 is an ATM inhibitor with potency, high selectivity, and oral activity.AZ31 inhibits ATM enzymes, intracellular ATM, with IC50 values of <1.2 nM and 46 nM, respectively.AZ31 exhibits excellent ATR selectivity, PIKK family selectivity, and pan-kinase selectivity.AZ31 is a potent in vitro radiosensitizer that can be used for cancer research.

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AZ31, CAS 2088113-98-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 59.00
5 mg	In stock	$ 132.00
10 mg	In stock	$ 193.00
25 mg	In stock	$ 423.00
50 mg	In stock	$ 627.00
100 mg	In stock	$ 893.00
1 mL * 10 mM (in DMSO)	In stock	$ 166.00

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Purity: 98.01%

ee: 100%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	AZ31 is an ATM inhibitor with potency, high selectivity, and oral activity.AZ31 inhibits ATM enzymes, intracellular ATM, with IC50 values of <1.2 nM and 46 nM, respectively.AZ31 exhibits excellent ATR selectivity, PIKK family selectivity, and pan-kinase selectivity.AZ31 is a potent in vitro radiosensitizer that can be used for cancer research.
Targets&IC50	ATM (oral):1.2 nM, ATM:46 nM
In vitro	AZ31 (0.3-3 μM ; 1 h) modulates the phosphorylation of a range of ATM targets.[2] AZ31 (10 μM ; 1 h) influences the stabilization of p53 in H2228 lung cancer cells post-radiation.[2]
In vivo	AZ31 (50-100 mg/kg ; p.o. twice daily) exhibits limited penetration into the brain.[2]

Synonyms	AZ 31, AZ-31
Molecular Weight	420.5
Formula	C24H28N4O3
CAS No.	2088113-98-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (59.45 mM)

References and Literature

1. Kiesel BF, et al. LC-MS/MS assay for the simultaneous quantitation of the ATM inhibitor AZ31 and the ATR inhibitor AZD6738 in mouse plasma. J Pharm Biomed Anal. 2017 ; 138:158-165. 2. Karlin J, et al. Orally Bioavailable and Blood-Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice. Mol Cancer Ther. 2018 ; 17(8):1637-1647. 3. Iglesias C, et al. Fracture bone healing and biodegradation of AZ31 implant in rats. Biomed Mater. 2015 ; 10(2):025008. 4. Song Y, et al. In vitro and in vivo assessment of biocompatibility of AZ31 alloy as biliary stents: a preclinical approach. Arch Med Sci. 2020 ; 18(1):195-205.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Inhibitor Library Highly Selective Inhibitor Library Anti-Obesity Compound Library Bioactive Compounds Library Max Anti-Cancer Compound Library DNA Damage & Repair Compound Library Kinase Inhibitor Library Bioactive Compound Library

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Keywords

AZ31 2088113-98-6 DNA Damage/DNA Repair PI3K/Akt/mTOR signaling ATM/ATR AZ 31 AZ-31 inhibitor inhibit

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