15
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T7814 | Alloxan monohydrate | Proteasome | |
Alloxan Monohydrate is a glucose analog used to induce diabetes by destroying beta-cells. | |||
T2154 | MG-132 | Z-LLL-al,Z-Leu-Leu-Leu-CHO | Apoptosis , Proteasome , Autophagy |
MG-132 (Z-Leu-Leu-Leu-al) is a 26S proteasome inhibitor (IC50=100 nM) that is cell-permeable and reversible. MG-132 acts as an autophagy activator and also induces apoptosis. | |||
T78353 | Alpha-2,6-Sialyltransferase (Pd26ST) | ||
Alpha-2,6-Sialyltransferase (Pd26ST) efficiently catalyzes the sialylation of both terminal and internal galactose and N-acetylgalactosamine residues, resulting in the production of terminal α2,6-sialosides [1]. | |||
T9090 | MUN57694 | Proteasome | |
MUN57694 is an inhibitor of 26S proteasome. | |||
T1932 | B-AP15 | NSC 687852 | Apoptosis , DUB |
B-AP15 (NSC-687852)(NSC-687852) is a selective inhibitor of the deubiquitinating enzymes Usp14 and UCHL5 of the 26S proteasome. It blocks the deubiquitinating activity of the 26S proteasome. | |||
T60487 | DDO-7263 | Nrf2 | |
DDO-7263 is a 1,2,4-Oxadiazole derivative that upregulates Nrf2 through binding to Rpn6 to block the assembly of 26S proteasome and the subsequent degradation of ubiquitinated Nrf2. DDO-7263 is a potent Nrf2 activator th... | |||
T36902 | RA375 | RA375 | Proteasome |
RA375, an inhibitor of RPN13 (26S proteasome regulatory subunit), enhances UPR signaling, ROS production, and apoptosis. Demonstrating ten times the efficacy against cancer lines compared to RA190, RA375 owes its increas... | |||
T21617 | MG-115 | Z-LL-Nva-CHO | Proteasome |
MG-115 (Z-LL-Nva-CHO) is a potent and reversible inhibitor of proteasome , with K i s of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifically inhibit the chymotrypsin-like activity of the proteas... | |||
T77796 | DL-Borneol | (endo)-Borneol,Borneol,(±)-Borneol | GABA Receptor , Endogenous Metabolite |
DL-Borneol ((endo)-Borneol) is a small molecule extracted from traditional Chinese medicine (TCM). It is an orally bioadjuvant that improves drug delivery to the brain and is commonly used as an adjuvant ingredient in TC... | |||
T37011 | Boc-LRR-AMC | ||
Boc-LRR-AMC is a fluorogenic substrate for the trypsin-like activity of the 26S proteasome or 20S proteolytic core. Upon enzymatic cleavage by the 26S proteasome or 20S proteolytic core, amino-4-methylcoumarin (AMC) is r... | |||
T76038 | Ac-Nle-Pro-Nle-Asp-AMC | ||
Ac-Nle-Pro-Nle-Asp-AMC is a specific substrate for the 26S proteasome and is utilized in analyzing the proteasome's caspase-like activity [1] [2] [3]. | |||
T77939 | WBC100 | 14-D-Valine-TPL | c-Myc |
WBC100 (14-D-Valine-TPL) is a potent, selective, and orally active c-Myc glue degrader that targets the ubiquitin E3 ligase CHIP-mediated 26S proteasome pathway, primarily utilized in research for c-Myc overexpressing tu... | |||
T37417 | Z-LLE-AMC | ||
Z-LLE-AMC is a fluorogenic substrate for the caspase-like post-glutamate peptide hydrolase of the 26S proteasome or 20S proteolytic core. Caspase-like activity can be quantified by fluorescent detection of free AMC (also... | |||
T37418 | Z-LLL-AMC | ||
Z-LLL-AMC is a fluorogenic substrate for the chymotrypsin-like activity of the 26S proteasome or 20S proteolytic core. Chymotrypsin-like activity can be quantified by fluorescent detection of free AMC (also known as 7-am... | |||
T62080 | GSK3494245 | ||
GSK3494245 (DDD01305143) is a potent, selective, orally active inhibitor of chymotrypsin-like activity that binds to the proteasome of WTL.donovani at an IC50 of 0.16 μM, sandwiched between the β4 and β5 subunits. GSK349... |