1a2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9704	1-Ethynylpyrene		P450
	1-Ethynylpyrene is an aryl acetylenic inhibitor of CYTP450 1A1(IC50=0.18 μM), 1A2(IC50 = 0.32 μM), and 2B1(IC50 = 0.04 μM).		P450
T39675	ALDH1A2-IN-1	ALDH1A2-IN-1
	ALDH1A2-IN-1 is a reversible inhibitor of the active site of ALDH1A2, showing a significant affinity for the enzyme with an IC50 value of 0.91 μM and a Kd value of 0.26 μM. This compound interacts hydrophobically with th...
T29468	61A2	61-A-2,61 A 2
	61A2, known as a stabilizer of the active LPL dimer can prevents LPL inactivation.
T7410	Furafylline		P450
	Furafylline is a selective inhibitor of human cytochrome P450 (CYP)1A2 (IC50 : 0.07 µM),		P450
T23533	WIN 18446		Dehydrogenase
	inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2)		Dehydrogenase
T2753	Avasimibe	PD-148515,CI-1011	P450 , Acyltransferase
	Avasimibe (PD-148515) is an orally bioavailable inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT, IC50: 3.3 μM) that prevents cholesterol deposition in the arterial wall. It also inhibits human P450 isoenz...		P450 , Acyltransferase
T0671	2-Naphthol	Betanaphthol	Others , Endogenous Metabolite
	2-Naphthol (Betanaphthol) is an isomer of 1-naphthol, differing by the location of the hydroxyl group on the naphthalene ring.		Others , Endogenous Metabolite
T3215	JNJ-42165279	JNJ42165279	FAAH , Autophagy
	JNJ-42165279 covalently inactivates the FAAH enzyme but is highly selective with regard to other enzymes, ion channels, transporters, and receptors. JNJ-42165279 (10 μM) exhibits high selectivity against a panel of 50 re...		FAAH , Autophagy
T1540	Doxepin hydrochloride	Toruan,Doxepin HCl,Aponal,Novoxapin	P450 , Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , AChR , Norepinephrine , Histamine Receptor
	Doxepin hydrochloride (Aponal) is a dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it ap...
T1415	Gemfibrozil	CI-719,Jezil,Decrelip,Lopid	P450 , Adrenergic Receptor , PPAR
	Gemfibrozil (CI-719) interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. Gemfi...		P450 , Adrenergic Receptor , PPAR
T13520	6-Hydroxymelatonin		Others
	6-Hydroxymelatonin is a primary metabolic of Melatonin, which is metabolized by CYP 1A2.		Others
T24988	7ETMC	7 ETMC,7-ETMC
	7ETMC is a selective Human Cytochrome P450s 1A1 and 1A2 inhibitor. 7ETMC showed IC50s of 0.46 μM and 0.50 μM for P450s 1A1 and 1A2 in the first six minutes, respectively, and did not show any inhibition activity for P450...
T39371	LKY-047
	LKY-047, a derivative of Decursin, is a highly effective and specific reversible competitive inhibitor of cytochrome P45022J2 (CYP2J2), with an IC 50 value of 1.7 μM. LKY-047 does not display inhibitory activity against ...
TN5133	3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone		HIV Protease , Topoisomerase
	5,7,3',5'-tetrahydroxy-6,4'-dimethoxyflavone exhibits anti-HIV-1 activity in the anti-syncytium assay using (∆Tat/rev)MC99 virus and 1A2 cell line system, it shows considerably activity against HIV-1 reverse transcriptas...		HIV Protease , Topoisomerase
T70782	PF-05139962
	PF-05139962 is a novel potent mTOR inhibitor with excellent mTOR biochemical inhibition, cellular potency, kinase selectivity and in vitro ADME properties. PF-05139962 has pS473 and pS6 cellular IC50 = 48 and 6 nM respec...
T11088	Doxepin D3 Hydrochloride		Histamine Receptor
	Doxepin D3 Hydrochloride is a deuterium-labeled doxepin hydrochloride.Doxepin hydrochloride is an oral active tricyclic antidepressant used as a sedative.Doxepin hydrochloride is also an effective CYP450 inhibitor, signi...		Histamine Receptor