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Tumor Necrosis Factor family, TNFs

The tumor necrosis factor (TNF) superfamily is a protein superfamily of type II transmembrane proteins containing TNF homology domain and forming trimers. Members of this superfamily can be released from the cell membrane by extracellular proteolytic cleavage and function as a cytokine. These proteins are expressed predominantly by immune cells and they regulate diverse cell functions, including immune response and inflammation, but also proliferation, differentiation, apoptosis and embryogenesis. The superfamily contains 19 members that bind to 29 members of TNF receptor superfamily. The tumor necrosis factor receptor superfamily (TNFRSF) is a protein superfamily of cytokine receptors characterized by the ability to bind tumor necrosis factors (TNFs) via an extracellular cysteine-rich domain.The PROSITE pattern of this superfamily is located in a beta sheet in the central section of the protein that is conserved across all members.

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Species
Canine (4)
Cynomolgus (19)
Ferret (2)
Human (70)
Mouse (30)
Rabbit (1)
Rat (9)
Rhesus (5)
Expression System
Baculovirus Insect Cells (4)
E. coli (23)
HEK293 Cells (107)
P. pastoris (Yeast) (3)
Tag
Avi (1)
C-6xHis (3)
C-His (4)
C-His-Avi (2)
C-hFc (2)
C-mFc (1)
N-10xHis (1)
N-6xHis (5)
N-6xHis-Avi (1)
N-6xHis-Flag (3)
N-8xHis (1)
N-Avi-Fc (1)
N-Avi-hFc (3)
N-Flag (4)
N-Flag-His (1)
N-His (20)
N-His-Avi (7)
N-His-Flag (11)
N-hFc (30)
N-mFc (8)
N-monomeric hFc (2)
N-rFc (6)
Tag Free (24)
hFc (1)
Cat No. product name / Synonyms Species Expression System
TMPK-00591 RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (aa 70-316, His)
RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (aa 70-316, His)
Mouse HEK293 Cells
Receptor activator of nuclear factor x03BA;B (RANK) and its ligand (RANKL) have originally been described for their key roles in bone metabolism and the immune s...
TMPK-00666 CD27 Ligand/CD70 Protein, Cynomolgus, Recombinant (His)
CD27 Ligand/CD70 Protein, Cynomolgus, Recombinant (His)
Cynomolgus HEK293 Cells
CD70, also named CD27 ligand (CD27L), is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and has been designated TNFSF7.  CD70 is a...
TMPK-00716 RANKL/TNFSF11/CD254 Protein, Human, Recombinant (aa 63-244)
RANKL/TNFSF11/CD254 Protein, Human, Recombinant (aa 63-244)
Human HEK293 Cells
Receptor activator of nuclear factor x03BA;B (RANK) and its ligand (RANKL) have originally been described for their key roles in bone metabolism and the immune s...
TMPK-00717 RANKL/TNFSF11/CD254 Protein, Human, Recombinant (His & Flag)
RANKL/TNFSF11/CD254 Protein, Human, Recombinant (His & Flag)
Human HEK293 Cells
Receptor activator of nuclear factor x03BA;B (RANK) and its ligand (RANKL) have originally been described for their key roles in bone metabolism and the immune s...
TMPK-00727 TNFSF12/TWEAK Protein, Human, Recombinant (hFc)
TNFSF12/TWEAK Protein, Human, Recombinant (hFc)
Human HEK293 Cells
Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a well known multifunctional cytokine extensively distributed in cell types and tissues. Accumula...
TMPK-00860 CD40 Ligand Protein, Mouse, Recombinant (monomeric hFc)
CD40 Ligand Protein, Mouse, Recombinant (monomeric hFc)
Mouse HEK293 Cells
CD40 ligand or CD40L, also called CD154,  is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It b...
TMPK-01011 TL1A/TNFSF15 Protein, Mouse, Recombinant (His & Avi)
TL1A/TNFSF15 Protein, Mouse, Recombinant (His & Avi)
Mouse HEK293 Cells
TNFSF15 Protein, Mouse, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with N-His-Avi tag. The predicted molecular weight is 24.40 kDa and the ac...
TMPK-01012 TL1A/TNFSF15 Protein, Mouse, Recombinant (His & Avi), Biotinylated
TL1A/TNFSF15 Protein, Mouse, Recombinant (His & Avi), Biotinylated
Mouse HEK293 Cells
TNFSF15 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with N-His-Avi tag. The predicted molecular weight is 24.40 ...
TMPK-01013 TL1A/TNFSF15 Protein, Mouse, Recombinant (hFc)
TL1A/TNFSF15 Protein, Mouse, Recombinant (hFc)
Mouse HEK293 Cells
TNFSF15 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The predicted molecular weight is 48.8 kDa and the accession num...
TMPK-01064 GITR Ligand/TNFSF18 Protein, Mouse, Recombinant (hFc)
GITR Ligand/TNFSF18 Protein, Mouse, Recombinant (hFc)
Mouse HEK293 Cells
Glucocorticoid-induced TNFR-related protein (TNFRSF18, GITR, CD357), expressed by T cells, and its ligand (TNFSF18, GITRL), expressed by myeloid populations, pro...
TMPK-01163 APRIL/TNFSF13 Protein, Mouse, Recombinant (His & Flag)
APRIL/TNFSF13 Protein, Mouse, Recombinant (His & Flag)
Mouse HEK293 Cells
The APRIL (a proliferation-inducing ligand), also known as TNFSF13, TALL2, TRDL1, and CD256, is a member of the TNF ligand superfamily.Both APRIL and its close r...
TMPK-01349 APRIL/TNFSF13 Trimer Protein, Cynomolgus, Recombinant (His & Avi, Flag)
APRIL/TNFSF13 Trimer Protein, Cynomolgus, Recombinant (His & Avi, Flag)
Cynomolgus HEK293 Cells
The APRIL (a proliferation-inducing ligand), also known as TNFSF13, TALL2, TRDL1, and CD256, is a member of the TNF ligand superfamily.Both APRIL and its close r...
TMPJ-01472 RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (Flag & His)
RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (Flag & His)
Mouse HEK293 Cells
RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with N-6xHis-Flag tag. The predicted molecular weight is 23-2...
TMPK-01398 CD40 Ligand Trimer Protein, Human, Recombinant (hFc)
CD40 Ligand Trimer Protein, Human, Recombinant (hFc)
Human HEK293 Cells
CD40 ligand or CD40L, also called CD154, is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It b...
TMPY-00248 Lymphotoxin Beta Protein, Cynomolgus, Recombinant (His)
Lymphotoxin Beta Protein, Cynomolgus, Recombinant (His)
Cynomolgus Baculovirus Insect Cells
LTB (Lymphotoxin Beta) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. Lymphotoxin beta is a type II membrane protein of the...
TMPY-00537 RANKL/TNFSF11/CD254 Protein, Cynomolgus, Recombinant (hFc)
RANKL/TNFSF11/CD254 Protein, Cynomolgus, Recombinant (hFc)
Cynomolgus HEK293 Cells
RANKL/TNFSF11/CD254 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 48.9 kDa and th...
TMPY-00584 TWEAK/TNFSF12 Protein, Mouse, Recombinant (hFc)
TWEAK/TNFSF12 Protein, Mouse, Recombinant (hFc)
Mouse HEK293 Cells
TWEAK/TNFSF12 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 44.4 kDa and the accession...
TMPY-00618 BAFF/TNFSF13B Protein, Canine, Recombinant (hFc)
BAFF/TNFSF13B Protein, Canine, Recombinant (hFc)
Canine HEK293 Cells
BAFF/TNFSF13B Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.5 kDa and the accessio...
TMPY-00959 4-1BB Ligand/TNFSF9 Protein, Mouse, Recombinant (His)
4-1BB Ligand/TNFSF9 Protein, Mouse, Recombinant (His)
Mouse HEK293 Cells
4-1BB Ligand/TNFSF9 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25 kDa and the acces...
TMPY-01239 BAFF/TNFSF13B Protein, Human, Recombinant (hFc)
BAFF/TNFSF13B Protein, Human, Recombinant (hFc)
Human HEK293 Cells
BAFF/TNFSF13B Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43.7 kDa and the accession...
RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (aa 70-316, His)
TMPK-00591
Receptor activator of nuclear factor x03BA;B (RANK) and its ligand (RANKL) have originally been described for their key roles in bone metabolism and the immune s...
CD27 Ligand/CD70 Protein, Cynomolgus, Recombinant (His)
TMPK-00666
CD70, also named CD27 ligand (CD27L), is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and has been designated TNFSF7.  CD70 is a...
RANKL/TNFSF11/CD254 Protein, Human, Recombinant (aa 63-244)
TMPK-00716
Receptor activator of nuclear factor x03BA;B (RANK) and its ligand (RANKL) have originally been described for their key roles in bone metabolism and the immune s...
RANKL/TNFSF11/CD254 Protein, Human, Recombinant (His & Flag)
TMPK-00717
Receptor activator of nuclear factor x03BA;B (RANK) and its ligand (RANKL) have originally been described for their key roles in bone metabolism and the immune s...
TNFSF12/TWEAK Protein, Human, Recombinant (hFc)
TMPK-00727
Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a well known multifunctional cytokine extensively distributed in cell types and tissues. Accumula...
CD40 Ligand Protein, Mouse, Recombinant (monomeric hFc)
TMPK-00860
CD40 ligand or CD40L, also called CD154,  is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It b...
TL1A/TNFSF15 Protein, Mouse, Recombinant (His & Avi)
TMPK-01011
TNFSF15 Protein, Mouse, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with N-His-Avi tag. The predicted molecular weight is 24.40 kDa and the ac...
TL1A/TNFSF15 Protein, Mouse, Recombinant (His & Avi), Biotinylated
TMPK-01012
TNFSF15 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with N-His-Avi tag. The predicted molecular weight is 24.40 ...
TL1A/TNFSF15 Protein, Mouse, Recombinant (hFc)
TMPK-01013
TNFSF15 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The predicted molecular weight is 48.8 kDa and the accession num...
GITR Ligand/TNFSF18 Protein, Mouse, Recombinant (hFc)
TMPK-01064
Glucocorticoid-induced TNFR-related protein (TNFRSF18, GITR, CD357), expressed by T cells, and its ligand (TNFSF18, GITRL), expressed by myeloid populations, pro...
APRIL/TNFSF13 Protein, Mouse, Recombinant (His & Flag)
TMPK-01163
The APRIL (a proliferation-inducing ligand), also known as TNFSF13, TALL2, TRDL1, and CD256, is a member of the TNF ligand superfamily.Both APRIL and its close r...
APRIL/TNFSF13 Trimer Protein, Cynomolgus, Recombinant (His & Avi, Flag)
TMPK-01349
The APRIL (a proliferation-inducing ligand), also known as TNFSF13, TALL2, TRDL1, and CD256, is a member of the TNF ligand superfamily.Both APRIL and its close r...
RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (Flag & His)
TMPJ-01472
RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with N-6xHis-Flag tag. The predicted molecular weight is 23-2...
CD40 Ligand Trimer Protein, Human, Recombinant (hFc)
TMPK-01398
CD40 ligand or CD40L, also called CD154, is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It b...
Lymphotoxin Beta Protein, Cynomolgus, Recombinant (His)
TMPY-00248
LTB (Lymphotoxin Beta) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. Lymphotoxin beta is a type II membrane protein of the...
RANKL/TNFSF11/CD254 Protein, Cynomolgus, Recombinant (hFc)
TMPY-00537
RANKL/TNFSF11/CD254 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 48.9 kDa and th...
TWEAK/TNFSF12 Protein, Mouse, Recombinant (hFc)
TMPY-00584
TWEAK/TNFSF12 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 44.4 kDa and the accession...
BAFF/TNFSF13B Protein, Canine, Recombinant (hFc)
TMPY-00618
BAFF/TNFSF13B Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.5 kDa and the accessio...
4-1BB Ligand/TNFSF9 Protein, Mouse, Recombinant (His)
TMPY-00959
4-1BB Ligand/TNFSF9 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25 kDa and the acces...
BAFF/TNFSF13B Protein, Human, Recombinant (hFc)
TMPY-01239
BAFF/TNFSF13B Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43.7 kDa and the accession...
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TargetMol