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Ziprasidone hydrochloride

Catalog No. T0031L CAS 122883-93-6

Synonyms: CP-88059 hydrochloride, CP-88059, Ziprasidone HCl

Ziprasidone hydrochloride (CP-88059 hydrochloride) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of antipsychotic activity.

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Ziprasidone hydrochloride Chemical Structure

Ziprasidone hydrochloride, CAS 122883-93-6

Pack Size	Availability	Price/USD
5 mg	In stock	$ 37.00
10 mg	In stock	$ 50.00
25 mg	In stock	$ 85.00
50 mg	In stock	$ 135.00
100 mg	In stock	$ 169.00
500 mg	In stock	$ 418.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.34%

Purity: 98.37%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Ziprasidone hydrochloride (CP-88059 hydrochloride) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of antipsychotic activity.
Targets&IC50	5-HT2A:0.42 nM (Ki), 5-HT1A receptor (human):2.5 nM (Ki), D2 receptor (rat):4.8 nM (Ki), 5-HT1A receptor (rat):3.4 nM (Ki)
In vitro	Ziprasidone exhibits an inherent protective mechanism against drug-induced increases in food intake, demonstrated by its ability to inhibit the significant enhancement of food consumption caused by olanzapine in rats. It also induces a notable upregulation of NGF and ChAT immunoreactivity in the hippocampal regions dentate gyrus, CA1, and CA3 of rats. Furthermore, Ziprasidone dose-dependently decreases the activity of midbrain central tegmental field neurons (ED50 = 300 mg/kg i.v.), similar to atypical antipsychotics like clozapine (ED50 = 250 mg/kg i.v.) and olanzapine (ED50 = 1000 mg/kg i.v.) in anesthetized rats. In Xenopus oocytes, Ziprasidone displays a lower inhibitory effect (IC50 = 2.8 mM) on the wild-type hERG current.
In vivo	Ziprasidone blocks wild-type hERG currents in a voltage and concentration-dependent manner with an IC(50) of 120 nM in stably transfected HEK-293 cells. Minimal hERG current blockade by ziprasidone is estimated during depolarized voltages (-20 or +30 mV) or assessed via envelope of tail test (+30 mV). The compound significantly prolongs the time constant of the slow component of hERG current deactivation at -50 mV. Ziprasidone acts as a 5-HT(1A) receptor agonist and antagonizes 5-HT(2A), 5-HT(2C), and 5-HT(1B/1D) receptors, similar to the antidepressant imipramine in inhibiting serotonin and norepinephrine neuronal uptake. It also exhibits high affinity for human 5-HT receptors and dopamine D(2) receptors.

Synonyms	CP-88059 hydrochloride, CP-88059, Ziprasidone HCl
Molecular Weight	449.4
Formula	C21H22CL2N4OS
CAS No.	122883-93-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 83 mg/mL (184.7 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Seeger TF, et al. J Pharmacol Exp Ther. 1995 Oct;275(1):101-13.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library GPCR Compound Library Inhibitor Library Anti-Cancer Drug Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library Anti-Neurodegenerative Disease Compound Library Membrane Protein-targeted Compound Library Histamine & Melatonin Receptor-Targeted Compound Library Anti-Cancer Compound Library

Related Products

Related compounds with same targets

PF-00217830 Oxolinic acid Tiospirone SLV-310 SB-277011 Propionylpromazine hydrochloride Risperidone Doxepin hydrochloride

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Keywords

Ziprasidone hydrochloride 122883-93-6 GPCR/G Protein Immunology/Inflammation Neuroscience 5-HT Receptor Dopamine Receptor Norepinephrine Histamine Receptor Adrenergic Receptor neuronal inhibit uptake rats Serotonin Receptor antipsychotic CP 88059 Hydrochloride CP-88059 hydrochloride 5-hydroxytryptamine Receptor CP88059 CP 88059 CP88059 Hydrochloride CP-88059 Hydrochloride CP-88059 Ziprasidone norepinephrine Ziprasidone HCl Sprague-Dawley Inhibitor Ziprasidone Hydrochloride inhibitor

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