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Triamcinolone acetonide

Catalog No. T0820 CAS 76-25-5

Synonyms: Aristogel, Azmacort, Aristoderm

Triamcinolone acetonide (Azmacort) is a Corticosteroid. The mechanism of action of triamcinolone acetonide is as a Corticosteroid Hormone Receptor Agonist. It is an anti-inflammatory glucocorticoid used topically in the treatment of various skin disorders. Intralesional, intramuscular, and intra-articular injections are also administered under certain conditions.

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Triamcinolone acetonide Chemical Structure

Triamcinolone acetonide, CAS 76-25-5

Pack Size	Availability	Price/USD	Quantity
1 g	In stock	$ 48.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.84%

Purity: 99.81%

Purity: 99.61%

Purity: 99.6%

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Description	Triamcinolone acetonide (Azmacort) is a Corticosteroid. The mechanism of action of triamcinolone acetonide is as a Corticosteroid Hormone Receptor Agonist. It is an anti-inflammatory glucocorticoid used topically in the treatment of various skin disorders. Intralesional, intramuscular, and intra-articular injections are also administered under certain conditions.
In vitro	In horses subjected to a second injection of lipopolysaccharide, Triamcinolone Acetonide reduced edema, lameness, and joint fluid protein concentration. In mice, Triamcinolone Acetonide, a synthetic glucocorticoid, induced cleft palate resulting from impaired palatal development. In the jaws of rat embryos, Triamcinolone Acetonide inhibited the proliferation of mesenchymal cells and affected the differentiation of MEE (Medial Edge Epithelium) cells into stratified squamous epithelial cells. Compared to methoxycarbonyl alone, Triamcinolone Acetonide increased both the white blood cell count and methoxycarbonyl concentration in the synovial fluid.
In vivo	Triamcinolone Acetonide reduced polysaccharide synthesis and increased the glycosaminoglycan (GAG) content in the culture medium compared to the blank group and IL-1 group. It also augmented GAG degradation. This compound significantly decreased the paracellular permeability of ECV304 cells and downregulated ICAM-1 expression, corroborating with immunocytochemical observations. In rat retinas, Triamcinolone reversed Müller glial cell swelling, a phenomenon observed under various experimental conditions: in retinas isolated 3 days post-transient retinal ischemia, in control retinas with 1 mM Ba^2+, 10 μM arachidonic acid, 200 μM H2O2, or 30 nM prostaglandin E2, and in retinas with lipopolysaccharide-induced ocular inflammation.

Synonyms	Aristogel, Azmacort, Aristoderm
Molecular Weight	434.5
Formula	C24H31FO6
CAS No.	76-25-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 13 mg/mL (29.91 mM)

DMSO: 87 mg/mL (200.23 mM)

References and Literature

1. Penfold PL, et al. Clin Exp Immunol,2000, 121(3), 458-465. 2. Uckermann O, et al. J Pharmacol Exp Ther,2005, 315(3), 1036-1045. 3. Dechant JE, et al. Equine Vet J. 2003 Jul;35(5):444-50. 4. Furukawa S, et al. J Vet Med Sci,2004, 66(4), 397-402. 5. Kay AT, et al. Am J Vet Res,2008, 69(12), 1646-1654. 6. Luo X L, Li J X, Huang H R, et al. LL37 inhibits Aspergillus fumigatus infection via directly binding to the fungus and preventing excessive inflammation[J]. Frontiers in immunology. 2019 Feb 20;10:283.

Citations

1. Luo X L, Li J X, Huang H R, et al. LL37 inhibits Aspergillus fumigatus infection via directly binding to the fungus and preventing excessive inflammation. Frontiers in Immunology. 2019, 10: 283

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Fluorochemical Library Anti-Fibrosis Compound Library Glutamine Metabolism Compound Library Pediatric Drug Library Anti-Cancer Compound Library ReFRAME Related Library Approved Drug Library

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Keywords

Triamcinolone acetonide 76-25-5 Endocrinology/Hormones Glucocorticoid Receptor inhibit Inhibitor Aristogel Azmacort Aristoderm inhibitor

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