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Setrobuvir

Catalog No. T28762 CAS 1071517-39-9

Synonyms: RO-5466731, ANA-598, RG7790, ANA598, RG-7790

Setrobuvir (ANA-598) is an orally active non-nucleoside HCV NS5B polymerase inhibitor with inhibitory effects on de novo RNA synthesis and primer extension with IC50s between 4 and 5 nM. setrobuvir shows good binding affinity for SARS-CoV-2 RdRp and induces inhibition of RdRp.

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Setrobuvir, CAS 1071517-39-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 240.00
5 mg	In stock	$ 600.00
10 mg	In stock	$ 855.00
25 mg	In stock	$ 1,280.00
50 mg	In stock	$ 1,750.00
100 mg	In stock	$ 2,360.00
500 mg	In stock	$ 4,730.00
1 mL * 10 mM (in DMSO)	In stock	$ 776.00

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Purity: 100%

Purity: 98.92%

ee: 96.18%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Setrobuvir (ANA-598) is an orally active non-nucleoside HCV NS5B polymerase inhibitor with inhibitory effects on de novo RNA synthesis and primer extension with IC50s between 4 and 5 nM. setrobuvir shows good binding affinity for SARS-CoV-2 RdRp and induces inhibition of RdRp.
Targets&IC50	RNA synthesis and primer extension:4~5 nM
In vivo	Setrobuvir (200, 400, and 800 mg) BID were -2.1, -2.2, and -2.9 log10 IU/mL, respectively (vs ≤0.1 log10 IU/mL with placebo).[3]

Synonyms	RO-5466731, ANA-598, RG7790, ANA598, RG-7790
Molecular Weight	560.62
Formula	C25H25FN4O6S2
CAS No.	1071517-39-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5.61 mg/mL (10 mM)

References and Literature

1. Yi G, et al. Biochemical study of the comparative inhibition of hepatitis C virus RNA polymerase by VX-222 and filibuvir. Antimicrob Agents Chemother. 2012 ; 56(2):830-837. 2. Elfiky AA. SARS-CoV-2 RNA dependent RNA polymerase (RdRp) targeting: an in silico perspective. J Biomol Struct Dyn. 2021 ; 39(9):3204-3212. doi:10.1080/07391102.2020.1761882 3. Mallalieu NL, et al. Pharmacokinetics and pharmacodynamics of setrobuvir, an orally administered hepatitis C virus non-nucleoside analogue inhibitor. Clin Ther. 2014 ; 36(12):2047-2063. 4. Eltahla AA, et al. Cross-genotypic examination of hepatitis C virus polymerase inhibitors reveals a novel mechanism of action for thumb binders. Antimicrob Agents Chemother. 2014 ; 58(12):7215-7224. 5. De Clercq E. Current race in the development of DAAs (direct-acting antivirals) against HCV. Biochem Pharmacol. 2014 ; 89(4):441-452.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Inhibitor Library Drug Repurposing Compound Library Anti-Cancer Drug Library Bioactive Compound Library Anti-Cancer Compound Library Bioactive Compounds Library Max Immunology/Inflammation Compound Library Clinical Compound Library

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Setrobuvir 1071517-39-9 Cell Cycle/Checkpoint DNA Damage/DNA Repair Microbiology/Virology Proteases/Proteasome SARS-CoV HCV Protease DNA/RNA Synthesis RO5466731 RO-5466731 ANA-598 RG7790 RO 5466731 ANA 598 ANA598 RG-7790 RG 7790 inhibitor inhibit

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