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Rimtuzalcap

Catalog No. T9522 CAS 2167246-24-2

Synonyms: CAD-1883

Rimtuzalcap (CAD-1883) (CAD-1883), a pioneering selective positive allosteric modulator of small-conductance calcium-activated potassium channels (SK channels), is employed in the study of movement disorders such as spinocerebellar ataxia (SCA) and essential tremor (ET).

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Rimtuzalcap, CAS 2167246-24-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 51.00
2 mg	In stock	$ 74.00
5 mg	In stock	$ 122.00
10 mg	In stock	$ 197.00
25 mg	In stock	$ 389.00
50 mg	In stock	$ 579.00
100 mg	In stock	$ 828.00
1 mL * 10 mM (in DMSO)	In stock	$ 163.00

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Purity: 99.54%

Biological Description

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Storage & Solubility Information

Description	Rimtuzalcap (CAD-1883) (CAD-1883), a pioneering selective positive allosteric modulator of small-conductance calcium-activated potassium channels (SK channels), is employed in the study of movement disorders such as spinocerebellar ataxia (SCA) and essential tremor (ET).
In vitro	Rimtuzalcap (Compound 1), a small-molecule modulator of potassium ion channels, exhibits significant therapeutic promise for addressing a range of diseases. These diseases are marked either by the dysfunction of potassium ion channels or by other factors affecting these channels[1].
In vivo	Rimtuzalcap (CAD-1883) effectively decreases Purkinje cell firing rate by about 40%, aligning with its expected therapeutic action of enhancing SK channel activity through positive allosteric modulation. When applied in sequence, either 1 or 3 µM of CAD-1883 can partially reverse the augmented coefficient of variation in interspike intervals noted in cerebellar slices from 11-month-old spinocerebellar ataxia-2 58Q mice[1].

Synonyms	CAD-1883
Molecular Weight	378.42
Formula	C18H24F2N6O
CAS No.	2167246-24-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 250 mg/mL (660.64 mM), Sonication is recommended.

References and Literature

1. Crystalline forms of potassium channel modulators. WO2020086456A1.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Bioactive Compound Library Ion Channel Inhibitor Library Bioactive Compounds Library Max Potassium Channel Blocker Library Clinical Compound Library Anti-Cancer Compound Library NO PAINS Compound Library

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Keywords

Rimtuzalcap 2167246-24-2 Membrane transporter/Ion channel Potassium Channel KcsA movement small-conductance channels CAD1883 CAD 1883 SK channels CAD-1883 tremor essential inhibit spinocerebellar potassium ataxia SCA Inhibitor disorders calcium-activated inhibitor

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