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Search Results for " kcsa "

20

Compounds

Cat No. Product Name Synonyms Targets
T10977 DCEBIO Potassium Channel
DCEBIO stimulates the secretion of Cl- through the activation of the hIK1 K + channel and the activation of the apical Cl- conductance. DCEBIO is a derivative of 1-EBIO and a very strong activator of Cl- secretion by T84...
T20968 CyPPA Potassium Channel , Dopamine Receptor
CyPPA, a subtype-selective positive modulator of SK channels, decreased spontaneous firing rate, increased the duration of the apamin-sensitive afterhyperpolarization.
T13164 Tipepidine hydrochloride Potassium Channel , Dopamine Receptor
Tipepidine hydrochloride is a reversible inhibitor of dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) (IC50: 7.0 μM), with antidepressant-like effect.
T2604 1-EBIO Calcium Channel
1-EBIO (1-EBIO) is a calium channel agonist.
T14982 Clofilium tosylate Potassium Channel
Clofilium tosylate is a potassium channel blocker. It induces apoptosis of human promyelocytic leukemia (HL-60) cells via Bcl-2-insensitive activation of caspase-3.
TN1092 O-Nornuciferine Potassium Channel , HER
O-Nornuciferine reveals distinct in vitro hERG blockages measured in HEK293 cells with the IC50 value of 2.89 uM.
T8189 Dihydroberberine Potassium Channel , HSP , HER
Dihydroberberine has anti-atherosclerotic, anti-inflammatory, hypolipidemic and antitumor activities. It inhibits human ether-a-go-go-related gene (hERG) channels and remarkably reduces Hsp90 expression and its interacti...
T4224 ML335 Potassium Channel
ML335 is a selective activator of TREK-1 and TREK-2.
T15385 Glibornuride Potassium Channel
Glibornuride is an ATP-sensitive K+ channels (KATP channel) blocker ( pKi: 5.75). It is an antidiabetic agent.
T7653 JNJ 303 Potassium Channel
JNJ 303 is a potent blocker of IKs (IC50 : 64 nM).
T10566 BMS-191095 Potassium Channel
BMS-191095 is mitochondrial ATP-sensitive potassium (mitoKATP) channel activator.
T0690 Quinine Potassium Channel , Platelet aggregation , Parasite
Quinine is a natural cinchona alkaloid that has been used for centuries in the prevention and therapy of malaria. Quinine is also used for idiopathic muscle cramps. Quinine therapy has been associated with rare instances...
T3959 ICA-069673 ICA069673 Potassium Channel
ICA-069673 is an activator of KCNQ2/Q3 potassium channel (IC50: 0.69 μM).
T3192 NS1643 Potassium Channel , HER , Autophagy
NS1643 is a potent human ether-a-go-go related gene (hERG) KV11.1 channel activator with EC50 of 10.5 μM.
T16110 ML418 Potassium Channel
ML418 is a potent, selective and CNS penetrating Kir7.1 potassium channel blocker (IC50 = 310 nM), and also potently inhibits Kir6.2/SUR1.
T22745 DPO-1 Potassium Channel
DPO-1 is a blocker of IKur ultrarapid delayed rectifier potassium current and KV1.5 channels
T7612 ICA 110381 Potassium Channel
ICA 110381 is a KCNQ2/Q3 potassium channel opener for the treatment of epilepsy
T12255 NS19504 Potassium Channel
NS19504 is an activator of Ca2+-activated K+ channel with EC50 of 11.0 µM. NS19504 shows relaxing effect on bladder smooth muscle spontaneous phasic contractions[1].
T5444 CLP290 CLP-290 Potassium Channel
CLP290 is an activator of the neuron-specific K+-Cl cotransporter KCC2 and displays potential for the treatment of a wide range of neurological and psychiatric indications.
T60061 RU-TRAAK-2 Potassium Channel
RU-TRAAK-2 is a reversible inhibitor of TWIK-related arachidonic acid-stimulated K+ channel with no activity for non-K2P channels including Kv1.2, GIRK2, and Slo1.
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