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Pregnenolone

Catalog No. T0851   CAS 145-13-1
Synonyms: 3β-Hydroxy-5-pregnen-20-one, Arthenolone

Pregnenolone (Arthenolone) is an endogenous steroid hormone synthesized from cholesterol, used in the treatment of Alzheimer's disease.

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Pregnenolone Chemical Structure
Pregnenolone, CAS 145-13-1
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500 mg In stock $ 45.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 100%
Purity: 99.5%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Pregnenolone (Arthenolone) is an endogenous steroid hormone synthesized from cholesterol, used in the treatment of Alzheimer's disease.
In vitro Pregnenolone induces a large, dose-related increase of both the rate and extent of MAP2-induced tubulin assembly, whereas progesterone, inactive per se, counteracted the stimulatory effect of Pregnenolone. Pregnenolone-increased assembly of microtubules produces a completely normal structure. [1] Pregnenolone preserves microtubule abundance and promotes cell movement during epiboly. [2] Pregnenolone results in dramatic reduction in GR nuclear localization in mouse hippocampal cell line (HT-22). Pregnenolone has neuroprotective effects against both glutamate and amyloid beta protein neuropathology. [3]
In vivo Pregnenolone sustains its proliferative activity in vivo and stimulates the growth of LNCaP-tumor xenografts in intact male SCID mice as well as in castrated animals. Pregnenolone is shown to activate transcription through the LNCaP androgen receptor (AR), but not the wild-type AR. [4] Pregnenolone results in a significant decrease in the accumulation of astrocytes in the proximity of the wound and in a decreased bromodeoxyuridine incorporation in reactive astrocytes of rats. [5] Pregnenolone administration results in elevations in downstream neurosteroids such as allopregnanolone, a molecule with neuroprotective effects that also increases neurogenesis, decreases apoptosis and inflammation, modulates the hypothalamic-pituitary-adrenal axis, and markedly increases GABA(A) receptor responses. Pregnenolone administration elevates pregnenolone sulfate, a neurosteroid that positively modulates NMDA receptors. [6]
Source
Synonyms 3β-Hydroxy-5-pregnen-20-one, Arthenolone
Molecular Weight 316.48
Formula C21H32O2
CAS No. 145-13-1

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 21 mg/mL (66.4 mM)

DMSO: 3.33 mg/mL (10.53 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

TargetMolReferences and Literature

1. Murakami K, et al. Proc Natl Acad Sci U S A, 2000, 97(7), 3579-3584. 2. Hsu HJ, et al. Nature,2006, 439(7075), 480-483. 3. Gursoy E, et al. Neurochem Res,2001, 26(1), 15-21. 4. Grigoryev DN, et al. J Steroid Biochem Mol Biol, 2000, 75(1), 1-10. 5. García-Estrada J, et al. Int J Dev Neurosci. 1999 Apr;17(2):145-51.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Approved Drug Library Human Endogenous Metabolite Library Anti-Neurodegenerative Disease Compound Library Tobacco Monomer Library Anti-Cancer Drug Library Inhibitor Library Natural Product Library Membrane Protein-targeted Compound Library Traditional Chinese Medicine Monomer Library Natural Product Library for HTS

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Keywords

Pregnenolone 145-13-1 Autophagy GPCR/G Protein Membrane transporter/Ion channel Metabolism Neuroscience Endogenous Metabolite Cannabinoid Receptor AChR TRP/TRPV Channel 3β-Hydroxy-5-pregnen-20-one Transient receptor potential channels inhibit 3beta-Hydroxy-5-pregnen-20-one TRP Channel Arthenolone 3b-Hydroxy-5-pregnen-20-one Inhibitor inhibitor

 

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