Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 38.00 | |
2 mg | In stock | Inquiry | |
5 mg | In stock | $ 88.00 | |
10 mg | In stock | $ 139.00 | |
25 mg | In stock | $ 247.00 | |
50 mg | In stock | $ 368.00 | |
100 mg | In stock | $ 543.00 | |
500 mg | In stock | $ 1,160.00 |
Description | Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). |
In vitro | Polyinosinic-polycytidylic acid (polyi:c) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor (TLR) 3 and retinoic acid inducible gene I (RIG-I)-like receptors (RLRs), including RIG-I and melanoma differentiation-associated gene 5 (MDA5). The effect of polyi:c on tumor immunotherapy has been well explored for several decades. The accumulated evidence suggests that polyi:c could be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Recent studies have also shown that activation of TLR3 and RLR signaling by polyi:c can directly trigger apoptosis in some cancer cells[2]. |
In vivo | Polyinosinic-polycytidylic acid inhibits tumor growth in NOD/SCID immunodeficient mice injected with 1205Lu cells. The level of human DNA is 50% lower in mice treated with Polyinosinic-polycytidylic acid[1]. |
Synonyms | Poly(I:C) sodium |
Molecular Weight | 695.403 |
Formula | (C10H13N4O8P)x.(C9H14N3O8P)x.xNa |
CAS No. | 42424-50-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 10 mg/mL, Sonication and heating are recommended.
You can also refer to dose conversion for different animals. More
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