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Myricetin

Catalog No. T0579   CAS 529-44-2
Synonyms: Cannabiscetin

Myricetin (Cannabiscetin) is a naturally-occurring flavonoid found in many grapes, berries, fruits, vegetables, herbs, as well as other plants. Walnuts are a rich dietary source. It has been shown that myricetin has antioxidant properties.

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Myricetin Chemical Structure
Myricetin, CAS 529-44-2
Pack Size Availability Price/USD Quantity
20 mg In stock $ 33.00
25 mg In stock $ 37.00
50 mg In stock $ 55.00
100 mg In stock $ 76.00
500 mg In stock $ 175.00
1 mL * 10 mM (in DMSO) In stock $ 61.00
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Purity: 99.85%
Purity: 99.45%
Purity: 98.83%
Purity: 98.58%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Myricetin (Cannabiscetin) is a naturally-occurring flavonoid found in many grapes, berries, fruits, vegetables, herbs, as well as other plants. Walnuts are a rich dietary source. It has been shown that myricetin has antioxidant properties.
Targets&IC50 PI3Kγ:0.17 μM(Kd)
In vivo Treatment of orthotopic pancreatic tumors with myricetin results in tumor regression and decreases metastatic spread[3].
Cell Research Pancreatic cancer cells (MIA PaCa-2, Panc-1 or S2-013) or normal pancreatic ductal cells (PDCs) are treated with myricetin (12.5–200 μM). Cell viability is determined using the Dojindo Cell Counting Kit-8. Cells are seeded onto a 96-well plate at 1×104 cells per well and allowed to adhere overnight. After treatment with myricetin at various concentrations for 24 hours, 10 μL of the tetrazolium substrate is added to each well of the plate. Plates are incubated at 37°C for 1 hour, after which the absorbance at 450 nm is measured[2].
Source
Synonyms Cannabiscetin
Molecular Weight 318.24
Formula C15H10O8
CAS No. 529-44-2

Storage

keep away from direct sunlight,keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 20 mg/mL (62.84 mM), warmed

DMSO: 63 mg/mL (197.96 mM)

TargetMolReferences and Literature

1. Knekt P, et al. Am J Clin Nutr, 2002, 76(3), 560-568. 2. Nothlings U, et al. Am J Epidemiol, 2007, 166(8), 924-931. 3. Phillips PA, et al. Cancer Lett, 2011, 308(2), 181-188. 4. Lee KW, et al. Carcinogenesis. 2007, 28(9):1918-27. 5. Walker EH, et al. Mol Cell. 2000, 6(4):909-19. 6. Semwal DK, et al. Myricetin: A Dietary Molecule with Diverse Biological Activities. Nutrients. 2016 Feb 16;8(2):90. 7. Xu Y, et al. Myricetin induces apoptosis via endoplasmic reticulum stress and DNA double-strand breaks in human ovarian cancer cells. Mol Med Rep. 2016 Mar;13(3):2094-100. 8. Liang Y, Xu Z, Wu X, et al. Inhibition of hyperpolarization-activated cyclic nucleotide-gated channels with natural flavonoid quercetin[J]. Biochemical and Biophysical Research Communications. 2020 9. Li W, Xu C, Hao C, et al. Inhibition of herpes simplex virus by myricetin through targeting viral gD protein and cellular EGFR/PI3K/Akt pathway[J]. Antiviral Research. 2020: 104714. 10. Shim K S, Hwang Y H, Jang S A, et al. . Water Extract of Lysimachia christinae Inhibits Trabecular Bone Loss and Fat Accumulation in Ovariectomized Mice[J]. Nutrients.  2020, 12(7): 1927.

TargetMolCitations

1. Shim K S, Hwang Y H, Jang S A, et al.  Water Extract of Lysimachia christinae Inhibits Trabecular Bone Loss and Fat Accumulation in Ovariectomized Mice. Nutrients. 2020, 12(7): 1927 2. Li W, Xu C, Hao C, et al. Inhibition of herpes simplex virus by myricetin through targeting viral gD protein and cellular EGFR/PI3K/Akt pathway. Antiviral Research. 2020: 104714. 3. Liang Y, Xu Z, Wu X, et al. Inhibition of hyperpolarization-activated cyclic nucleotide-gated channels with natural flavonoid quercetin. Biochemical and Biophysical Research Communications. 2020 4. Tang X, Liu L, Li Y, et al.Chemical profiling and investigation of molecular mechanisms underlying anti-hepatocellular carcinoma activity of extracts from Polygonum perfoliatum L.Biomedicine & Pharmacotherapy.2023, 166: 115315. 5. Sinkar S, Kombe S, Malik N, et al.Myricetin and its derivatives; potential therapeutic effect on human health: a review.Arabian Journal of Medicinal and Aromatic Plants.2023, 9(2): 167-209. 6. Yuan N, Diao J, Dong J, et al.Targeting ROCK1 in diabetic kidney disease: Unraveling mesangial fibrosis mechanisms and introducing myricetin as a novel antagonist.Biomedicine & Pharmacotherapy.2024, 171: 116208.

Related compound libraries

This product is contained In the following compound libraries:
Tyrosine Kinase Inhibitor Library Tobacco Monomer Library Miao medicine Compound Library Anti-Cancer Active Compound Library Ferroptosis Compound Library The Yao nationality medicine Library Drug Metabolite/Impurity Library Reprogramming Compound Library Bioactive Compounds Library Max Anti-COVID-19 Traditional Chinese Medicine Compound Library

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Keywords

Myricetin 529-44-2 Apoptosis Autophagy Metabolism PI3K/Akt/mTOR signaling PI3K Endogenous Metabolite Inhibitor inhibit Cannabiscetin inhibitor

 

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