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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T14971 | CIQ | NMDAR | |
CIQ is a subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit. EC50 value: 2.7 μM for NR2C and 2.8 μM for NR2D. | |||
T12406 | PEPA | iGluR | |
PEPA is an allosteric AMPA receptors modulator; binds to the GluA2o and GluA3o LBDs and can be utilized as an indicator of AMPA receptor heterogeneity. | |||
T16402 | Org-26576 | GluR , iGluR | |
Org-26576 is a positive allosteric modulator of the AMPA receptor. | |||
T12234 | NMDA-IN-1 | NMDAR | |
NMDA-IN-1 is a potent and NR2B-selective antagonist of NMDA(NMDA Ki of 0.85 nM; NR2B Ca2+ influx IC50 is 9.7 nM). | |||
T8920 | Sepimostat | iGluR | |
Sepimostat exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. Sepimostat dimethanesulfonate inhibits the Ifenprodil binding with a Ki v... | |||
T20993 | Memantine | Others | |
Memantine, an amantadine derivative with some dopaminergic effects, has been proposed as an antiparkinson agent and has may be used to treat moderate to severe Alzheimer's disease. It acts on the glutamatergic system by ... | |||
T2362 | QNZ46 | NMDAR , iGluR | |
QNZ46 is a NR2C/NR2D-selective NMDA receptor non-competitive antagonist. | |||
T15623 | JNJ-61432059 | iGluR | |
JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8 (pIC50: 9.7 for GluA1/γ-8). | |||
T17293 | ZL006 | NMDAR , iGluR | |
ZL006 is an effective inhibitor of nNOS/PSD-95 interaction. ZL006 also inhibits NMDA receptor-mediated NO synthesis. | |||
T9626 | Cycloleucine | NMDAR | |
Cycloleucine is an antagonist of NMDA receptor associated glycine receptor with a Ki of 600 μM. Cycloleucine is also a competitive inhibitor of S-adenosyl-methionine mediated methylation with anxiolytic and cytostatic ef... | |||
T7355 | IC87201 | Others , iGluR | |
IC87201 is a nNOS-PDZ/PSD-95-PDZ inhibitor. IC87201 showed great promise in cellular experiments and animal models of ischemic stroke and pain. | |||
T1897 | MDL-29951 | NMDAR , iGluR | |
MDL-29951 is a novel glycine antagonist of NMDA receptor activation. | |||
T4573 | Cyclothiazide | GluR | |
Cyclothiazide is a benzothiadiazide that acts as a potentiator of AMPA receptorsthat potently inhibits AMPA receptor desensitization, positively modulating its response to glutamic acid (EC50 = 3.8 M). | |||
T5522 | NMDAR antagonist 1 | Others , iGluR | |
NMDAR antagonist 1 is an orally active, NR2B-selective NMDAR antagonist. | |||
TQ0289 | LY450108 | iGluR | |
LY450108 is a potentiator of the AMPA receptor that can be used in Parkinson's disease studies. | |||
TQ0233 | Traxoprodil | CP101606 | NMDAR , iGluR |
Traxoprodil (CP101606) is a selective NMDA antagonist and protects hippocampal neurons (IC50: 10 nM). | |||
T8458 | CNQX disodium | iGluR | |
CNQX disodium is a competitive non-NMDA receptor antagonist and competitive AMPA/kainate receptor antagonist in neuronal cultures. | |||
T4171 | PEAQX | NVP-AAM077 | NMDAR , iGluR |
PEAQX (NVP-AAM077)(NVP-AAM 077) is an effective and orally available NMDA antagonist. It can inhibit human NMDA receptors for 1A/2A(IC50: 270 nM), rather than 1A/2B(29, 600 nM). | |||
T1186 | Ifenprodil Tartrate | Potassium Channel , NMDAR , iGluR | |
Ifenprodil is a selective NMDA receptor (glutamate) antagonist. | |||
T5385 | Radiprodil | RGH-896 | NMDAR , iGluR |
Radiprodil (RGH-896) (RGH-896) is an orally active and selective NMDA NR2B receptors antagonist. It was a potential treatment of neuropathic pain associated with diabetic peripheral neuropathy (DPNP). |