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Search Results for " iglur "

20

Compounds

Cat No. Product Name Synonyms Targets
T14971 CIQ NMDAR
CIQ is a subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit. EC50 value: 2.7 μM for NR2C and 2.8 μM for NR2D.
T12406 PEPA iGluR
PEPA is an allosteric AMPA receptors modulator; binds to the GluA2o and GluA3o LBDs and can be utilized as an indicator of AMPA receptor heterogeneity.
T16402 Org-26576 GluR , iGluR
Org-26576 is a positive allosteric modulator of the AMPA receptor.
T12234 NMDA-IN-1 NMDAR
NMDA-IN-1 is a potent and NR2B-selective antagonist of NMDA(NMDA Ki of 0.85 nM; NR2B Ca2+ influx IC50 is 9.7 nM).
T8920 Sepimostat iGluR
Sepimostat exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. Sepimostat dimethanesulfonate inhibits the Ifenprodil binding with a Ki v...
T20993 Memantine Others
Memantine, an amantadine derivative with some dopaminergic effects, has been proposed as an antiparkinson agent and has may be used to treat moderate to severe Alzheimer's disease. It acts on the glutamatergic system by ...
T2362 QNZ46 NMDAR , iGluR
QNZ46 is a NR2C/NR2D-selective NMDA receptor non-competitive antagonist.
T15623 JNJ-61432059 iGluR
JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8 (pIC50: 9.7 for GluA1/γ-8).
T17293 ZL006 NMDAR , iGluR
ZL006 is an effective inhibitor of nNOS/PSD-95 interaction. ZL006 also inhibits NMDA receptor-mediated NO synthesis.
T9626 Cycloleucine NMDAR
Cycloleucine is an antagonist of NMDA receptor associated glycine receptor with a Ki of 600 μM. Cycloleucine is also a competitive inhibitor of S-adenosyl-methionine mediated methylation with anxiolytic and cytostatic ef...
T7355 IC87201 Others , iGluR
IC87201 is a nNOS-PDZ/PSD-95-PDZ inhibitor. IC87201 showed great promise in cellular experiments and animal models of ischemic stroke and pain.
T1897 MDL-29951 NMDAR , iGluR
MDL-29951 is a novel glycine antagonist of NMDA receptor activation.
T4573 Cyclothiazide GluR
Cyclothiazide is a benzothiadiazide that acts as a potentiator of AMPA receptorsthat potently inhibits AMPA receptor desensitization, positively modulating its response to glutamic acid (EC50 = 3.8 M).
T5522 NMDAR antagonist 1 Others , iGluR
NMDAR antagonist 1 is an orally active, NR2B-selective NMDAR antagonist.
TQ0289 LY450108 iGluR
LY450108 is a potentiator of the AMPA receptor that can be used in Parkinson's disease studies.
TQ0233 Traxoprodil CP101606 NMDAR , iGluR
Traxoprodil (CP101606) is a selective NMDA antagonist and protects hippocampal neurons (IC50: 10 nM).
T8458 CNQX disodium iGluR
CNQX disodium is a competitive non-NMDA receptor antagonist and competitive AMPA/kainate receptor antagonist in neuronal cultures.
T4171 PEAQX NVP-AAM077 NMDAR , iGluR
PEAQX (NVP-AAM077)(NVP-AAM 077) is an effective and orally available NMDA antagonist. It can inhibit human NMDA receptors for 1A/2A(IC50: 270 nM), rather than 1A/2B(29, 600 nM).
T1186 Ifenprodil Tartrate Potassium Channel , NMDAR , iGluR
Ifenprodil is a selective NMDA receptor (glutamate) antagonist.
T5385 Radiprodil RGH-896 NMDAR , iGluR
Radiprodil (RGH-896) (RGH-896) is an orally active and selective NMDA NR2B receptors antagonist. It was a potential treatment of neuropathic pain associated with diabetic peripheral neuropathy (DPNP).
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TargetMol