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Capecitabine

Catalog No. T1408   CAS 154361-50-9
Synonyms: Xeloda, Capecitibine, Capiibine, RO 09-1978

Capecitabine (Capecitibine) is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moiety, 5-fluorouracil (5-FU); subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate for incorporation into the RNA strand.

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Capecitabine Chemical Structure
Capecitabine, CAS 154361-50-9
Pack Size Availability Price/USD Quantity
500 mg In stock $ 46.00
1 g In stock $ 62.00
5 g In stock $ 163.00
1 mL * 10 mM (in DMSO) In stock $ 48.00
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Purity: 100%
Purity: 99.89%
Purity: 99.53%
Purity: 99.37%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Capecitabine (Capecitibine) is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moiety, 5-fluorouracil (5-FU); subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate for incorporation into the RNA strand.
Cell Research HepG2 and either LS174T WT or LS174T-c2 cells are seeded, respectively, in the top and bottom chambers of 8-well strip membranes in 96-well plates. The exponentially growing cells are exposed to increasing concentrations of capecitabine. The medium is supplemented with 750 ng/mL ZB4 MoAB or 100 ng/mL BR17 MoAB when the latter are used in the experiments. After 72 hours of continuous exposure, LS174T viability is assessed using the classic colorimetric MTT test.(Only for Reference)
Synonyms Xeloda, Capecitibine, Capiibine, RO 09-1978
Molecular Weight 359.35
Formula C15H22FN3O6
CAS No. 154361-50-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 35.9 mg/mL (100 mM)

DMSO: 35.9 mg/mL (100 mM)

TargetMolReferences and Literature

1. Ciccolini J, et al. Mol Cancer Ther. 2002, 1(11), 923-927. 2. Ishikawa T, et al. Biochem Pharmacol. 1998, 55(7), 1091-1097. 3. Zhou J, et al. Clin Cancer Res. 2003, 9(16), 6030-6037.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Approved Drug Library Anti-Cancer Active Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Fluorochemical Library Target-Focused Phenotypic Screening Library Anti-Aging Compound Library Human Metabolite Library Anti-Cancer Compound Library Anti-Cardiovascular Disease Compound Library

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Keywords

Capecitabine 154361-50-9 Apoptosis Cell Cycle/Checkpoint DNA Damage/DNA Repair Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Xeloda inhibit Capecitibine Inhibitor Capiibine RO 09-1978 inhibitor

 

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