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Capecitabine

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Purity:100%

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COA HPLC HNMR

Capecitabine

Catalog No. T1408Cas No. 154361-50-9

Capecitabine (Capecitibine) is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moiety, 5-fluorouracil (5-FU); subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate for incorporation into the RNA strand.

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Pack Size	Price	Availability
500 mg	$46	In Stock
1 g	$62	In Stock
5 g	$163	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock

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Product Introduction

Bioactivity

Description	Capecitabine (Capecitibine) is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moiety, 5-fluorouracil (5-FU); subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate for incorporation into the RNA strand.
In vitro	When administered to mice with a high propensity for liver metastasis, Capecitabine exhibits inhibitory effects on both the growth and metastatic recurrence of human hepatocellular carcinoma. This phenomenon is attributed to the high expression of platelet-driven endothelial growth factor within the tumors. Compared to 5-FU, UFT, and the intermediate metabolite 5'-DFUR, Capecitabine demonstrates a broader spectrum of anticancer activity against human transplant tumors, which is associated with the tumor levels of dThdPase.
In vivo	Capecitabine induces apoptosis in a Fas-dependent manner and exhibits toxicity sevenfold higher towards LS174T-c2 cells, which are transfected with thymidine phosphorylase, leading to more pronounced apoptosis. When cultured in the same plate as HepG2 cells, both LS174TWT and LS174T-c2 cells show increased sensitivity to Capecitabine, with IC50 values decreasing from 890 μM when LS174TWT cells are cultured alone to 630 μM when co-cultured with HepG2 cells. Additionally, for the LS174T-C2 subtype co-cultured with HepG2 cells, the IC50 significantly drops from 330±4 μM to 89±6 μM.
Cell Research	HepG2 and either LS174T WT or LS174T-c2 cells are seeded, respectively, in the top and bottom chambers of 8-well strip membranes in 96-well plates. The exponentially growing cells are exposed to increasing concentrations of capecitabine. The medium is supplemented with 750 ng/mL ZB4 MoAB or 100 ng/mL BR17 MoAB when the latter are used in the experiments. After 72 hours of continuous exposure, LS174T viability is assessed using the classic colorimetric MTT test.(Only for Reference)
Alias	Xeloda, Capecitibine, Capiibine, RO 09-1978

Chemical Properties

Molecular Weight	359.35
Formula	C15H22FN3O6
Cas No.	154361-50-9

Storage & Solubility Information

Storage

|Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

5% DMSO+95% Saline: 1.8 mg/mL (5 mM)

Ethanol: 35.9 mg/mL (100 mM)

DMSO: 35.9 mg/mL (100 mM)

Solution Preparation Table

Ethanol/5% DMSO+95% Saline

	1mg	5mg	10mg	50mg
1 mM	2.7828 mL	13.9140 mL	27.8280 mL	139.1401 mL

Ethanol

	1mg	5mg	10mg	50mg
5 mM	0.5566 mL	2.7828 mL	5.5656 mL	27.8280 mL
10 mM	0.2783 mL	1.3914 mL	2.7828 mL	13.9140 mL
20 mM	0.1391 mL	0.6957 mL	1.3914 mL	6.9570 mL
50 mM	0.0557 mL	0.2783 mL	0.5566 mL	2.7828 mL
100 mM	0.0278 mL	0.1391 mL	0.2783 mL	1.3914 mL

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