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Cytoskeletal Signaling Akt Boehmenan

Boehmenan

Catalog No. TN3525   CAS 57296-22-7

(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in a competitive manner. Boehmenan exhibits the potent cytotoxic effects against many cancer cell lines, boehmenan-mediated anti-tumor property is mediated by modulation of mitochondria and EGFR signaling pathway in A549 NSCLC cells.

Boehmenan, CAS 57296-22-7
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1 mg Inquiry 307.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description (±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in a competitive manner. Boehmenan exhibits the potent cytotoxic effects against many cancer cell lines, boehmenan-mediated anti-tumor property is mediated by modulation of mitochondria and EGFR signaling pathway in A549 NSCLC cells.
Targets&IC50 Akt ,   Caspase ,   EGFR ,   ERK ,   MEK ,   p21 ,   p53 ,   PARP ,   PTP1B ,   STAT ,   Wnt/β-catenin
Molecular Weight 712.8
Formula C40H40O12
CAS No. 57296-22-7

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Chemical constituents from Sambucus adnata and their protein-tyrosine phosphatase 1B inhibitory activities. Chem Pharm Bull (Tokyo). 2011;59(11):1396-9. 2. Boehmenan, a lignan from the Chinese medicinal plant Clematis armandii, induces apoptosis in lung cancer cells through modulation of EGF-dependent pathways. Phytomedicine. 2016 May 15;23(5):468-76.

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