p53 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T72026	p53-MDM2-IN-1		Mdm2 , p53
	p53-MDM2-IN-1 (Example 30), an inhibitor targeting the p53-MDM2/X protein interaction, exhibits a K i value of 23.35 µM. This compound holds potential for applications in anti-tumor research.		Mdm2 , p53
T67698	p53-Mdm2 inhibitor 4		Mdm2 , p53
	p53-Mdm2 inhibitor 4 inhibits the p53-MDM2 protein-protein interaction.		Mdm2 , p53
T72771	p53 Activator 7
	P53 Activator 7 is an activator of the p53 Y220C mutation (MDM-2/p53), featuring an EC50 value of 104 nM. It has the capability to bind to the mutated p53, reinstating its DNA-binding function.
T80233	p53 CBS	p53 Consensus binding sequence
	p53 CBS (p53 Consensus binding sequence), a biologically active peptide, functions as the p53 consensus DNA binding site.
T24440	MDM2-p53-IN-1b	MDM2-p53 inhibitor 1b,MDM2 p53 IN 1b
	MDM2-p53-IN-1b is the MDM2-p53 interaction inhibitor.
TP1794	p53 (17-26)	p53 17-26
	This peptide is amino acids 17 to 26 fragment of p53, the Mdm-2 binding domain of p53 known also as p53N. This sequence contains all of the residues that contact the binding domain of Mdm-2.
T12351	p53 and MDM2 proteins-interaction-inhibitor (racemic)	p53-and-mdm2-proteins-interaction-inhibitor-racemic	Others
	p53 and MDM2 proteins-interaction-inhibitor (racemic) is an inhibitor of the interaction between p53 and MDM2 proteins.		Others
T67858	STIMA-1	2-Vinylquinazolin-4-ol,p53 Activator VII	Others
	STIMA-1 (2-Vinylquinazolin-4-ol), an active compound, can restore the activity of p63. STIMA-1 can stimulate the proliferation and differentiation of keratinocytes.		Others
TP2281	p53 tumor suppressor fragment		Others
	p53 tumor suppressor fragment (232-240) is a peptide with the sequence H2N-Lys-Tyr-Met-Cys-Asn-Ser-Ser-Cys-Met-OH, MW= 1066.3. p53 is a tumor suppressor protein that in humans is encoded by the TP53 gene. p53 is crucial ...		Others
T72770	p53 Activator 5
	P53 Activator 5 is a potent activator of p53, exhibiting a SC150 value of less than 0.05 mM. It effectively binds to mutant p53, restoring its DNA-binding capability. Additionally, P53 Activator 5 demonstrates significan...
T12350	p53 and MDM2 proteins-interaction-inhibitor dihydrochloride		Others
	p53 and MDM2 proteins-interaction-inhibitor dihydrochloride is a interaction inhibitor between p53 and MDM2 proteins.		Others
T72769	p53 Activator 3
	p53 Activator 3 is a potent activator of p53, demonstrating notable efficacy with an SC150 value of less than 0.05 mM. It effectively binds to mutant p53, reinstating its DNA-binding capability, and exhibits anti-tumor a...
T61369	p53 Activator 2
	p53 Activator 2 (compound 10ah) intercalates into DNA, causing significant DNA double-strand breaks and upregulates the expression of p53, p-p53, CDK4, and p21, leading to cell cycle arrest at the G2/M phase. It induces ...
T72877	p53-HDM2-IN-1
	p53-HDM2-IN-1 is a potent inhibitor of the p53-HDM2 protein-protein interaction, demonstrating an inhibitory concentration (IC 50) of 0.103 μM. This compound has significant applications in cancer research.
T74935	MDM2/4-p53-IN-2
	MDM2/4-p53-IN-2 (2q) is a potent dual inhibitor of MDM2/MDM4 and activator of p53, demonstrating IC50 values of 70.7 nM for MDM2-p53 and 81.4 nM for MDM4-p53 complexes. It facilitates cell cycle regulation, promotes apop...
T64079	Mutant p53 modulator-1
	Mutant p53 modulator-1 is a mutant p53 modulator. mutant p53 modulator-1 is able to hinder the progression of cancers containing p53 mutations.
T72832	MDM2-p53-IN-16
	MDM2-p53-IN-16 is a potent inhibitor of the MDM2-p53 complex, exhibiting an IC 50 value of 4.3 nM for the dissociation of the human p53/MDM2 complex. It effectively reactivates p53, leading to apoptosis and cell-cycle ar...
T63373	S100A2-p53-IN-1
	S100A2-p53-IN-1 (compound 51), an inhibitor of S100A2-p53 interactions, targets S100A2, a Ca 2+ binding protein involved in cell signaling and commonly upregulated in pancreatic cancer. This compound effectively inhibits...
T22980	MIRA-1	p53 Activator VIII,1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione,(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl propionate,NSC 19630,WRN Helicase Inhibitor	DNA/RNA Synthesis , p53
	MIRA-1 (WRN Helicase Inhibitor) is a restorer of wild-type p53 conformation/cellular function and selectively inhibits Werner syndrome WRN helicase activity with an IC50 of 20 µM.		DNA/RNA Synthesis , p53
T34830	Tetrofosmin	P 53,P53
	Tetrofosmin is a phosphine developed to overcome the non-target uptake of radioligands by the generation of hetero-atomic compounds.