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BQR-695

Catalog No. T4220 CAS 1513879-21-4

Synonyms: BQR695, BQR 695, NVP-BQR695

BQR-695 is a phosphatidylinositol 4-kinase (PI4K) inhibitor with IC50s of 80 and 3.5 nM for human PI4KIIIβ and Plasmodium variant of PI4KIIIβ, respectively.

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BQR-695, CAS 1513879-21-4

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	BQR-695 is a phosphatidylinositol 4-kinase (PI4K) inhibitor with IC50s of 80 and 3.5 nM for human PI4KIIIβ and Plasmodium variant of PI4KIIIβ, respectively.
Targets&IC50	human PI4KIIIβ:80 nM, PlasmodiμM variant of PI4KIIIβ:3.5 nM
In vitro	BQR695 shows no evidence of toxicity against mature red blood cells (RBCs), induces a schizont-stage arrest indistinguishable from that observed in imidazopyrazine-treated parasites and exhibits cross-resistance with the imidazopyrazine-resistant lines. Treatment with 0.5 μM of either KAI407 or BQR695 causes GFP-PHOsh2 to redistribute to the parasite plasma membrane, consistent with depletion of intracellular PI4P upon inhibition of PfPI4K function.

Synonyms	BQR695, BQR 695, NVP-BQR695
Molecular Weight	352.394
Formula	C19H20N4O3
CAS No.	1513879-21-4

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 100 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Fowler ML, et al. Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIβ with Rab11. Protein Sci. 2016 Apr;25(4):826-39. 2. McNamara CW, et al. Targeting Plasmodium PI(4)K to eliminate malaria. Nature. 2013 Dec 12;504(7479):248-253.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Anti-Lung Cancer Compound Library HIF-1 Signaling Pathway Compound Library Cancer Cell Differentiation Compound Library Glycometabolism Compound Library Anti-Cancer Metabolism Compound Library Anti-Obesity Compound Library Anti-Pancreatic Cancer Compound Library Inhibitor Library Anti-Breast Cancer Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BQR-695 1513879-21-4 PI3K/Akt/mTOR信号通路微生物学 Parasite PI3K PI4K PI4 kinases BQR 695 Inhibitor BQR695 inhibit Phosphatidylinositol 4 kinases NVP-BQR695 inhibitor

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