Powder: -20°C for 3 years
In solvent: -80°C for 2 years
BQR-695 is a phosphatidylinositol 4-kinase (PI4K) inhibitor with IC50s of 80 and 3.5 nM for human PI4KIIIβ and Plasmodium variant of PI4KIIIβ, respectively.
Description | BQR-695 is a phosphatidylinositol 4-kinase (PI4K) inhibitor with IC50s of 80 and 3.5 nM for human PI4KIIIβ and Plasmodium variant of PI4KIIIβ, respectively. |
Targets&IC50 | human PI4KIIIβ:80 nM, PlasmodiμM variant of PI4KIIIβ:3.5 nM |
In vitro | BQR695 shows no evidence of toxicity against mature red blood cells (RBCs), induces a schizont-stage arrest indistinguishable from that observed in imidazopyrazine-treated parasites and exhibits cross-resistance with the imidazopyrazine-resistant lines. Treatment with 0.5 μM of either KAI407 or BQR695 causes GFP-PHOsh2 to redistribute to the parasite plasma membrane, consistent with depletion of intracellular PI4P upon inhibition of PfPI4K function. |
Synonyms | BQR695, BQR 695, NVP-BQR695 |
Molecular Weight | 352.394 |
Formula | C19H20N4O3 |
CAS No. | 1513879-21-4 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 100 mg/mL
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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BQR-695 1513879-21-4 PI3K/Akt/mTOR信号通路 微生物学 Parasite PI3K PI4K PI4 kinases BQR 695 Inhibitor BQR695 inhibit Phosphatidylinositol 4 kinases NVP-BQR695 inhibitor