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BQR-695
🥰Excellent
Catalog No. T4220Cas No. 1513879-21-4
Alias NVP-BQR695, BQR695
BQR-695 (NVP-BQR695) is a phosphatidylinositol 4-kinase (PI4K) inhibitor with IC50s of 80 and 3.5 nM for human PI4KIIIβ and Plasmodium variant of PI4KIIIβ, respectively.
BQR-695
🥰Excellent
Purity: 99.69%
Catalog No. T4220Alias NVP-BQR695, BQR695Cas No. 1513879-21-4
BQR-695 (NVP-BQR695) is a phosphatidylinositol 4-kinase (PI4K) inhibitor with IC50s of 80 and 3.5 nM for human PI4KIIIβ and Plasmodium variant of PI4KIIIβ, respectively.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $64 | In Stock | |
| 10 mg | $89 | In Stock | |
| 25 mg | $197 | In Stock | |
| 50 mg | $289 | In Stock | |
| 100 mg | $455 | In Stock | |
| 500 mg | $987 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $70 | In Stock |
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Purity:99.69%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | BQR-695 (NVP-BQR695) is a phosphatidylinositol 4-kinase (PI4K) inhibitor with IC50s of 80 and 3.5 nM for human PI4KIIIβ and Plasmodium variant of PI4KIIIβ, respectively. |
| Targets&IC50 | PI4KIIIβ (human):80 nM, P. falciparum (PI4KIIIβ):3.5 nM |
| In vitro | BQR695 demonstrates no toxicity towards mature red blood cells (RBCs), triggers a schizont-stage halt akin to the effects seen in imidazopyrazine-treated parasites, and shows cross-resistance with imidazopyrazine-resistant strains. Administering 0.5 μM of KAI407 or BQR695 leads to the redistribution of GFP-PHOsh2 to the parasite's plasma membrane, indicating a decrease in intracellular PI4P due to the inhibition of PfPI4K activity. |
| Alias | NVP-BQR695, BQR695 |
| Molecular Weight | 352.39 |
| Formula | C19H20N4O3 |
| Cas No. | 1513879-21-4 |
| Smiles | CNC(=O)CNc1cnc2ccc(cc2n1)-c1ccc(OC)c(OC)c1 |
| Relative Density. | 1.250 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (141.89 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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