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Almonertinib mesylate

Catalog No. T9865 CAS 2134096-06-1

Almonertinib mesylate is an irreversible inhibitor of EGFR tyrosine kinase with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib mesylate can be used in the non-small cell lung cancer studies.

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Almonertinib mesylate Chemical Structure

Almonertinib mesylate, CAS 2134096-06-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 84.00
5 mg	In stock	$ 197.00
10 mg	In stock	$ 328.00
25 mg	In stock	$ 558.00
50 mg	In stock	$ 788.00
100 mg	In stock	$ 1,120.00
500 mg	In stock	$ 2,230.00
1 mL * 10 mM (in DMSO)	In stock	$ 288.00

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Purity: 98.85%

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Description	Almonertinib mesylate is an irreversible inhibitor of EGFR tyrosine kinase with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib mesylate can be used in the non-small cell lung cancer studies.
Targets&IC50	EGFR (T790M):0.37 nM, EGFR (L858R/T790M):0.29 nM, EGFR (del19/T790M):0.21 nM
In vitro	Almonertinib shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 (IC50: 0.37, 0.29 and 0.21 nM, respectively), and is less effective against wild type (3.39 nM)[1]. Additionaly, HS-10296 could also inhibit other EGFR sensitive mutations, including G719X, del19, L858R and L861Q[2].

Molecular Weight	621.75
Formula	C31H39N7O5S
CAS No.	2134096-06-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (48.25 mM), Sonication and heating to 60℃ are recommended.

References and Literature

1. Sullivan I, et al. Next-Generation EGFR Tyrosine Kinase Inhibitors for Treating EGFR-Mutant Lung Cancer beyond First Line. Front Med (Lausanne). 2017 Jan 18;3:76. 2. Wu SG, et al. Management of acquired resistance to EGFR TKI-targeted therapy in advanced non-small cell lung cancer. Mol Cancer. 2018 Feb 19;17(1):38. 3. Yang JC, et al. Safety, Efficacy, and Pharmacokinetics of Almonertinib (HS-10296) in Pretreated Patients With EGFR-Mutated Advanced NSCLC: A Multicenter, Open-label, Phase 1 Trial [published online ahead of print, 2020 Sep 9]. J Thorac Oncol. 2020;S1556-0864(20)30714-0.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Kinase Inhibitor Library Tyrosine Kinase Inhibitor Library Anti-Cancer Active Compound Library Membrane Protein-targeted Compound Library Highly Selective Inhibitor Library Anti-Pancreatic Cancer Compound Library Anti-Cancer Compound Library Bioactive Compound Library Anti-Breast Cancer Compound Library

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BKI-1369 Mutated EGFR-IN-1 LY 456236 hydrochloride WZ4002 Biochanin A Erlotinib Alflutinib EGFR-IN-81

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Keywords

Almonertinib mesylate 2134096-06-1 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR Almonertinib EGFR tyrosine kinase inhibitor Inhibitor HER1 ErbB-1 third-generation HS-10296 HS 10296 orally available inhibit Epidermal growth factor receptor irreversible Almonertinib Mesylate HS10296 non-small cell lung cancer inhibitor

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