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TargetMol | Compound Library

Tyrosine Kinase Inhibitor Library

Catalog No. L2200

A protein kinase is a kinase enzyme that modifies other molecules, mostly proteins, by chemically adding phosphate groups to them (phosphorylation) to regulate the majority of cellular pathways, especially those involved in signal transduction. Phosphorylation usually results in a functional change of the target protein (substrate) by changing enzyme activity, cellular location, or association with other proteins. Of the 518 known kinases, the most successful class for drug targeting is the tyrosine kinase family consisting of 90 distinct and diverse members. Abnormal expression of PTK usually leads to cell proliferation disorders, and is closely related to tumor invasion, metastasis and tumor angiogenesis. More recently, PTKs play a pivotal role in inflammatory diseases such as idiopathic pulmonary fibrosis.

The Tyrosine Kinase Inhibitors Library by TargetMol, containing 1120 tyrosine kinase inhibitors, can be used for research in tyrosine kinase signaling, and drug screening for related diseases.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L2200

Tyrosine Kinase Inhibitor Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Packaging And Storage Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
  • This compound library is provided at a concentration of 10 mM in DMSO. A small number of compounds may be provided in different solvents or concentrations due to solubility or stability requirements. Please refer to the specific product information for details.

Product Description Product Description

  • A unique collection of 1120 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase related diseases;
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA;
  • Targets include c-Kit, c-Met, EGFR, FGFR, SRC, JAK, SYK, Btk, Bcr-Abl, etc;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

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Library Customization | TargetMol Library Composition

EGFR
Apoptosis
VEGFR
JAK
Src
FLT
Autophagy
PDGFR
FGFR
c-Met/HGFR
c-Kit
Bcr-Abl
ALK
PKA
Tyrosine Kinases
CDK
IGF-1R
FAK
c-RET
c-Fms
TAM Receptor
Trk receptor
HER
TGF-beta/Smad
Akt
Potassium Channel
Syk
Aurora Kinase
Raf
PKC
DYRK
BTK
ERK
p38 MAPK
Ephrin Receptor
STAT
Endogenous Metabolite
ROS Kinase
NF-κB
CSF-1R
PI3K
GSK-3
S6 Kinase
Antibacterial
Discoidin Domain Receptor (DDR)
mTOR
5-HT Receptor
Tie-2
PYK2
Caspase
ROCK
ROS
MEK
TNF
JNK
Serine/threonin kinase
Calcium Channel
Reactive Oxygen Species
Ferroptosis
Parasite
Drug Metabolite
Chk
Cytochromes P450
MAPK
Casein Kinase
Influenza Virus
Microtubule Associated
Antibiotic
HIV Protease
PROTACs
Virus Protease
IκB/IKK
Tyrosinase
Ligands for Target Protein for PROTAC
Mitophagy
ACK1
COX
DNA/RNA Synthesis
SARS-CoV
HDAC
Sodium Channel
MLK
Antifungal
Histamine Receptor
Phosphatase
Pim
RIP kinase
PDE
CaMK
Bcl-2 Family
Beta Amyloid
AMPK
SGK
AChR
Histone Methyltransferase
HCV Protease
PARP
Hck
Adrenergic Receptor
MAO
IL Receptor
Interleukin
MNK
Antiviral
HSP
TLR
PDK
Phospholipase
PLK
IRAK
Ras
GPCR
Integrin
Dehydrogenase
Antioxidant
Adenosine Receptor
IFNAR
PPAR
Serine Protease
Topoisomerase
IRE1
Myosin
LDL
GRK
PAK
HSV
MMP
GluR
Wee1
Prostaglandin Receptor
Reverse Transcriptase
Anti-infection
Sigma receptor
p53
Monoamine Oxidase
NO Synthase
IKZF
Melanin-concentrating Hormone Receptor (MCHR)
Proton pump
Carbonic Anhydrase
DHFR
GDNF
ROR
DNA-PK
Estrogen/progestogen Receptor
YAP
Na+/Ca2+ Exchanger
NADPH
PERK
GTPase
c-Myc
Estrogen Receptor/ERR
HBV
Wnt/beta-catenin
Rho
Antifolate
Serotonin Transporter
Cell Cycle Arrest
Nucleoside Antimetabolite/Analog
LIM Kinase
FXR
Glucokinase
NAMPT
iGluR
E1/E2/E3 Enzyme
Haspin Kinase
Gamma-secretase
NMDAR
Mitochondrial Metabolism
Monoamine Transporter
DNA Alkylation
Hedgehog/Smoothened
FAAH
CCR
Angiotensin-converting Enzyme (ACE)
PAD
Lipoxygenase
Epigenetic Reader Domain
Norepinephrine
DUB
Telomerase
BCRP
P-gp
LRRK2
Sirtuin
Histone Acetyltransferase
transporter
cGAS
PAI-1
MELK
RSV
Hippo pathway
Kras
Protease
CRISPR/Cas9
GABA Receptor
Hydroxylase
HIF
MDM-2/p53
Gap Junction Protein
DAPK
NADPH-oxidase
p97
HIF/HIF Prolyl-Hydroxylase
IGF-2R