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LY 456236 hydrochloride

Catalog No. T22954 CAS 338736-46-2

Synonyms: MPMQ hydrochloride

LY 456236 hydrochloride (MPMQ hydrochloride) is an mGlu1 receptor antagonist with an ic50 value of 143 nM. LY456236 has selective, non-competitive and oral activity, and can inhibit the hydrolysis of inositol phosphate with IC50 of 0.145 μM. LY 456236 hydrochloride inhibited EGFR with IC50 of 0.91 μM.

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LY 456236 hydrochloride Chemical Structure

LY 456236 hydrochloride, CAS 338736-46-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 119.00
5 mg	In stock	$ 296.00
10 mg	In stock	$ 472.00
25 mg	In stock	$ 758.00
50 mg	In stock	$ 987.00
100 mg	In stock	$ 1,380.00
500 mg	In stock	$ 2,790.00

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Purity: 99.89%

Biological Description

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Description	LY 456236 hydrochloride (MPMQ hydrochloride) is an mGlu1 receptor antagonist with an ic50 value of 143 nM. LY456236 has selective, non-competitive and oral activity, and can inhibit the hydrolysis of inositol phosphate with IC50 of 0.145 μM. LY 456236 hydrochloride inhibited EGFR with IC50 of 0.91 μM.
Targets&IC50	mGlu1:0.145 μM, EGFR:0.91 μM
In vitro	LY456236 (2 μM; 30 min) reduces the proliferation of OCCM-30 cells stimulated by DHPG .[1]
In vivo	LY456236 exhibits anticonvulsant effects in mice (3-100 mg/kg; i.p.; once) and rats (10-60 mg/kg; oral; once).[2]

Synonyms	MPMQ hydrochloride
Molecular Weight	317.77
Formula	C16H16ClN3O2
CAS No.	338736-46-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 225.0 mg/mL (708.1 mM), Sonication and heating to 60℃ are recommended.

References and Literature

1. Kanaya S, et al. Metabotropic glutamate receptor 1 promotes cementoblast proliferation via MAP kinase signaling pathways. Connect Tissue Res. 2016;57(5):417-426. 2. Shannon HE,et al. Anticonvulsant effects of LY456236, a selective mGlu1 receptor antagonist. Neuropharmacology. 2005;49 Suppl 1:188-195. 3. Ravikumar B,et al. Chemogenomic Analysis of the Druggable Kinome and Its Application to Repositioning and Lead Identification Studies. Cell Chem Biol. 2019;26(11):1608-1622.e6.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Tyrosine Kinase Inhibitor Library Membrane Protein-targeted Compound Library Anti-Cancer Compound Library Bioactive Compounds Library Max Neuronal Signaling Compound Library Bioactive Compound Library

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PD153035 PD168393 Tyrphostin B44, (+) enantiomer ALK-IN-1 AG-825 TAK-285 Pimurutamab Neolinine

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Keywords

LY 456236 hydrochloride 338736-46-2 Angiogenesis JAK/STAT signaling Neuroscience Tyrosine Kinase/Adaptors EGFR GluR MPMQ hydrochloride LY 456236 Hydrochloride LY-456236 Hydrochloride MPMQ Hydrochloride LY456236 Hydrochloride inhibitor inhibit

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