α1a — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T74557	α1A-AR Degrader 9c		PROTACs
	α1A-AR Degrader 9c is a potent, selective, and reversible PROTAC degrader targeting the α1A adrenergic receptor (α1A-AR) with a DC50 of 2.86 μM. It promotes the proteasomal degradation of the α1A-AR and exhibits anti-pro...		PROTACs
T1132	Nicergoline	Nicergolinum,Nimergoline	Adrenergic Receptor
	Nicergoline (Nicergolinum) is an ergot derivative used to treat senile dementia and other disorders with vascular origins.		Adrenergic Receptor
T16798	RS 17053 hydrochloride	RS-17053	Others , Adrenergic Receptor
	RS 17053 hydrochloride is a potent and selective antagonist of α1A adrenoceptor. RS 17053 hydrochloride exhibits a pKi value of 9.1 in native cell membrane and a pA2 value of 9.8 in functional assays.		Others , Adrenergic Receptor
T17310	Phenylephrine	L-Phenylephrine,(R)-(-)-Phenylephrine	Adrenergic Receptor
	Phenylephrine ((R)-(-)-Phenylephrine) is a selective α1-adrenoceptor agonist ( pKi: 5.86, 4.87 and 4.70 for α1D, α1B, and α1A receptors respectively).		Adrenergic Receptor
T23301	(S)-(+)-Niguldipine hydrochloride		Others
	(S)-(+)-Niguldipine hydrochloride is a L-type Ca2+ channel blocker and α1A-adrenoceptor antagonist.		Others
T23253	RS 100329 hydrochloride	RS-100329	Adrenergic Receptor
	RS 100329 hydrochloride is an antagonist of α1A-adrenergic receptor.		Adrenergic Receptor
T12643	(R)-Terazosin		Adrenergic Receptor
	(R)-Terazosin is an active R-enantiomer of Terazosin. (R)-Terazosin is a potent antagonist of α1-adrenoceptor (α1a, α1b and α1d-adrenoceptor with Ki values of 6.51 nM, 1.01 nM and 1.97 nM, respectively).		Adrenergic Receptor
T9220	Naftopidil hydrochloride	1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-,KT-611 hydrochloride,BM-15275 hydrochloride	Adrenergic Receptor
	Naftopidil hydrochloride (BM-15275 hydrochloride) is a selective alpha1-adrenoceptor antagonist with Ki of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-adrenoceptor, α1b-adrenoceptor and α1d-adrenoceptor, respective...		Adrenergic Receptor
T13110	Tedatioxetine hydrobromide	Lu AA 24530 hydrobromide	Dopamine Receptor , 5-HT Receptor , Norepinephrine
	Tedatioxetine hydrobromide (Lu AA 24530 hydrobromide) is a serotonin-norepinephrine-dopamine reuptake inhibitor and an antagonist of 5-HT2A, 5-HT2C, 5-HT3, and α1A-adrenergic receptors, which can be used to treat depress...		Dopamine Receptor , 5-HT Receptor , Norepinephrine
T34795	Tedatioxetine	Lu AA-24530,Lu AA24530,Lu AA 24530
	Tetaxetine( LU AA24530) has been reported as a triple reuptake inhibitor (5-HT > NE > DA) and 5-HT2A, 5-HT2C, 5-HT3 and α1A-adrenergic receptor antagonist.Meanwhile, it is an antidepressant agent.
T1504	Silodosin	KAD 3213,KMD 3213	Adrenergic Receptor
	Silodosin (KAD 3213) is an alpha-Adrenergic Blocker. The mechanism of action of silodosin is as an Adrenergic alpha-Antagonist.		Adrenergic Receptor
T15688	L-771688	SNAP 6383	Adrenergic Receptor
	L-771688 (SNAP 6383) is a novel potent and selective α1A-adrenoceptor antagonist with a Ki value of 0.43±0.02 nM.L-771688 KE is used for the treatment of benign prostatic hyperplasia.		Adrenergic Receptor
T11286	Fiduxosin	A 185980.1,ABT 980	Adrenergic Receptor
	Fiduxosin is a selective and potent α1-adrenoceptor antagonist with inhibitory effects on α1a-adrenoceptor, α1b-adrenoceptor and α1d-adrenoceptor, with Ki values of 0.160 nM, 24.9 nM and 0.920 nM, respectively. Fiduxosin...		Adrenergic Receptor
T9762	Upidosin	SB-216469,SB 216469,Rec 15-2739,Recordati 15/2739	Adrenergic Receptor
	Upidosin (SB-216469) is a potential uroselective α1-adrenoceptor antagonist, α1a subtype Ki=0.34 nM, α1b subtype Ki=3.9 nM, α1d subtype Ki=1.5 nM, α2-adrenoceptor Ki=33.3 nM.		Adrenergic Receptor
T0453	Phenylephrine hydrochloride	NCI-c55641,Phenylephrine HCl,(R)-(-)-Phenylephrine hydrochloride	Endogenous Metabolite , Adrenergic Receptor
	Phenylephrine hydrochloride (NCI-c55641) is a selective agonist of the α1-adrenergic receptor.		Endogenous Metabolite , Adrenergic Receptor
T1090	Perphenazine	Perphenazin,Etaperazine,Trilafon	CaMK , Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , Histamine Receptor
	Perphenazine (Trilafon) is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.
T0696	Naftopidil	KT-611,BM-15275	Adrenergic Receptor
	Naftopidil (KT-611) (INN, marketed under the brand name Flivas), an antihypertensive medicine, is used as a selective α1-adrenergic receptor antagonist or α-blocker.		Adrenergic Receptor
T6600	Naftopidil dihydrochloride	KT-611,KT-611 2HCl,Naftopidil DiHCl	5-HT Receptor , Adrenergic Receptor
	Naftopidil dihydrochloride (KT-611 2HCl) is a selective 5-HT1A and α1-adrenergic receptor antagonist with IC50 of 0.1 μM and 0.2 μM, respectively.		5-HT Receptor , Adrenergic Receptor
T3046	BMY 7378 dihydrochloride	BMY7378 HCl	Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor
	BMY 7378 dihydrochloride (BMY7378 HCl) , α1D-adrenergic receptor antagonist, is a weak partial agonist/antagonist of 5-HT1A receptor.		Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor
T23532	WB 4101 hydrochloride		Others
	α1A-adrenergic antagonist		Others