Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Naftopidil hydrochloride (BM-15275 hydrochloride) is a selective alpha1-adrenoceptor antagonist with Ki of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-adrenoceptor, α1b-adrenoceptor and α1d-adrenoceptor, respectively. Naftopidil hydrochloride has antiproliferative effects.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 61.00 | |
2 mg | In stock | $ 87.00 | |
5 mg | In stock | $ 131.00 | |
10 mg | In stock | $ 198.00 | |
25 mg | In stock | $ 356.00 | |
50 mg | In stock | $ 533.00 | |
100 mg | In stock | $ 769.00 | |
500 mg | In stock | $ 1,580.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 163.00 |
Description | Naftopidil hydrochloride (BM-15275 hydrochloride) is a selective alpha1-adrenoceptor antagonist with Ki of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-adrenoceptor, α1b-adrenoceptor and α1d-adrenoceptor, respectively. Naftopidil hydrochloride has antiproliferative effects. |
Targets&IC50 | α1D-adrenoceptor:1.2 nM, α1A-adrenoceptor (human):3.7 nM, α1B-adrenoceptor:20 nM |
In vitro | Naftopidil hydrochloride reduced the extent of lung fibrosis and SP‐D production in bleomycin‐induced lung fibrosis in mice[1]. |
In vivo | Naftopidil hydrochloride strongly suppressed cell proliferation of stromal cells, resulting in decreased tumorigenic soluble factor, suggesting that naftopidil might be effective in preventing stromal support of tumor cells[2]. |
Synonyms | 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-, KT-611 hydrochloride, BM-15275 hydrochloride |
Molecular Weight | 428.95 |
Formula | C24H29ClN2O3 |
CAS No. | 1164469-60-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/ml (139.88 mM)
You can also refer to dose conversion for different animals. More
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Naftopidil hydrochloride 1164469-60-6 GPCR/G Protein Neuroscience Adrenergic Receptor BM-15275 BM15275 canine 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3- prostatic KT611 Hydrochloride Naftopidil prostate KT-611 Hydrochloride hyperplasia inhibit BM-15275 Hydrochloride KT 611 Hydrochloride Inhibitor KT-611 BM 15275 Hydrochloride KT611 Naftopidil Hydrochloride KT-611 hydrochloride BM-15275 hydrochloride KT 611 pressure BM15275 Hydrochloride BM 15275 Beta Receptor inhibitor