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RS 100329 hydrochloride

Catalog No. T23253   CAS 1215654-26-4
Synonyms: RS-100329

RS 100329 hydrochloride is an antagonist of α1A-adrenergic receptor.

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RS 100329 hydrochloride Chemical Structure
RS 100329 hydrochloride, CAS 1215654-26-4
Pack Size Availability Price/USD Quantity
1 mg In stock $ 44.00
5 mg In stock $ 97.00
10 mg In stock $ 178.00
25 mg In stock $ 387.00
50 mg In stock $ 576.00
100 mg In stock $ 823.00
500 mg In stock $ 1,680.00
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Purity: 100%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description RS 100329 hydrochloride is an antagonist of α1A-adrenergic receptor.
In vitro In intact CHO-K1 cells expressing human cloned alpha1A-, alpha1B- and alpha1D-AR showed nanomolar affinity and significant alpha1A-AR subtype selectivity for RS 100329 hydrochloride (pKi 9.6: 126 and 50 fold selectivity) over the alpha1B- and alpha1D-AR subtypes respectively. Noradrenaline-induced contractions of human lower urinary tract (LUT) tissues or rabbit bladder neck were competitively antagonized by RS 100329 hydrochloride (pA2 9.2 and 9.2)[1].
Synonyms RS-100329
Molecular Weight 462.89
Formula C20H26ClF3N4O3
CAS No. 1215654-26-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 40 mg/mL (86.4 mM)

TargetMolReferences and Literature

1. Williams TJ, et al. In vitro alpha1-adrenoceptor pharmacology of Ro 70-0004 and RS-100329, novel alpha1A-adrenoceptor selective antagonists. Br J Pharmacol. 1999 May;127(1):252-8. 2. Ribeiro CA, Pupo AS. Involvement of α1B-adrenoceptors in the anti-immobility effect of imipramine in the tail suspension test. Eur J Pharmacol. 2015 Mar 5;750:39-42.

Related compound libraries

This product is contained In the following compound libraries:
Neuronal Signaling Compound Library Neurotransmitter Receptor Compound Library Anti-Cancer Compound Library Inhibitor Library Bioactive Compounds Library Max Bioactive Compound Library

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Keywords

RS 100329 hydrochloride 1215654-26-4 GPCR/G Protein Neuroscience Adrenergic Receptor RS 100329 RS-100329 RS100329 inhibitor inhibit

 

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