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Phenylephrine

Phenylephrine
Phenylephrine ((R)-(-)-Phenylephrine) is a selective α1-adrenoceptor agonist ( pKi: 5.86, 4.87 and 4.70 for α1D, α1B, and α1A receptors respectively).
Catalog No. T17310Cas No. 59-42-7
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Purity:99.92%
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Phenylephrine

Catalog No. T17310Cas No. 59-42-7

Phenylephrine ((R)-(-)-Phenylephrine) is a selective α1-adrenoceptor agonist ( pKi: 5.86, 4.87 and 4.70 for α1D, α1B, and α1A receptors respectively).
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Pack SizePriceAvailabilityQuantity
500 mg$42In Stock
1 mL x 10 mM (in DMSO)$46In Stock
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Product Introduction

Bioactivity
Description
Phenylephrine ((R)-(-)-Phenylephrine) is a selective α1-adrenoceptor agonist ( pKi: 5.86, 4.87 and 4.70 for α1D, α1B, and α1A receptors respectively).
Targets&IC50
α1A-adrenoceptor:4.70 (pKi), α1D-adrenoceptor:5.86 (pKi), α1B-adrenoceptor:4.87 (pKi)
In vitro
Phenylephrine promotes cardiac fibroblast proliferation. Phenylephrine activates CaN and evokes NFAT3 nuclear translocation. It suggests that the Ca(2+)/CaN/NFAT pathway mediates Phenylephrine-induced cardiac fibroblast proliferation, and this pathway might be a possible therapeutic target in cardiac fibrosis [1][2][3].
In vivo
Phenylephrine could enhance the alveolar fluid clearance in high tidal volume-ventilated rats and accelerate the absorption of pulmonary edema. Perfusion of hearts with Phenylephrine (100 μM) induces a rapid (maximal at 10 min) 12-fold activation of two p38-MAPK isoforms. α1-adrenoceptor agonists such as Phenylephrine increase the contractility of the heart. Phenylephrine also activates SAPKs/JNKs in neonatal ventricular myocytes [4][5].
AliasL-Phenylephrine, (R)-(-)-Phenylephrine
Chemical Properties
Molecular Weight167.21
FormulaC9H13NO2
Cas No.59-42-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 100 mg/mL (598.05 mM), Sonication is recommended.
H2O: 5 mg/mL (29.90 mM), Sonication is recommended.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM5.9805 mL29.9025 mL59.8050 mL299.0252 mL
5 mM1.1961 mL5.9805 mL11.9610 mL59.8050 mL
10 mM0.5981 mL2.9903 mL5.9805 mL29.9025 mL
20 mM0.2990 mL1.4951 mL2.9903 mL14.9513 mL
DMSO
1mg5mg10mg50mg
50 mM0.1196 mL0.5981 mL1.1961 mL5.9805 mL
100 mM0.0598 mL0.2990 mL0.5981 mL2.9903 mL

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