Shopping Cart

Remove All
Your shopping cart is currently empty

Phenylephrine

Name: Phenylephrine
Brand: TargetMol
SKU: T17310
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T17310Cas No. 59-42-7

Alias L-Phenylephrine, (R)-(-)-Phenylephrine

Phenylephrine ((R)-(-)-Phenylephrine) is a selective α1-adrenoceptor agonist ( pKi: 5.86, 4.87 and 4.70 for α1D, α1B, and α1A receptors respectively).

Phenylephrine

🥰Excellent

Purity: 99.89%

Catalog No. T17310Alias L-Phenylephrine, (R)-(-)-PhenylephrineCas No. 59-42-7

Phenylephrine ((R)-(-)-Phenylephrine) is a selective α1-adrenoceptor agonist ( pKi: 5.86, 4.87 and 4.70 for α1D, α1B, and α1A receptors respectively).

Pack Size	Price	Availability	Quantity
500 mg	$42	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock

Add to Cart

Add to Quotation

Bulk & Custom

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.89%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Phenylephrine ((R)-(-)-Phenylephrine) is a selective α1-adrenoceptor agonist ( pKi: 5.86, 4.87 and 4.70 for α1D, α1B, and α1A receptors respectively).
Targets&IC50	α1A-adrenoceptor:4.70 (pKi), α1D-adrenoceptor:5.86 (pKi), α1B-adrenoceptor:4.87 (pKi)
In vitro	Phenylephrine promotes cardiac fibroblast proliferation. Phenylephrine activates CaN and evokes NFAT3 nuclear translocation. It suggests that the Ca(2+)/CaN/NFAT pathway mediates Phenylephrine-induced cardiac fibroblast proliferation, and this pathway might be a possible therapeutic target in cardiac fibrosis [1][2][3].
In vivo	Phenylephrine could enhance the alveolar fluid clearance in high tidal volume-ventilated rats and accelerate the absorption of pulmonary edema. Perfusion of hearts with Phenylephrine (100 μM) induces a rapid (maximal at 10 min) 12-fold activation of two p38-MAPK isoforms. α1-adrenoceptor agonists such as Phenylephrine increase the contractility of the heart. Phenylephrine also activates SAPKs/JNKs in neonatal ventricular myocytes [4][5].
Synonyms	L-Phenylephrine, (R)-(-)-Phenylephrine

Chemical Properties

Molecular Weight	167.21
Formula	C₉H₁₃NO₂
Cas No.	59-42-7
Smiles	CNC[C@H](O)c1cccc(O)c1
Relative Density.	1.1222 g/cm3 (Estimated)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (598.05 mM), Sonication is recommended.

H2O: 5 mg/mL (29.90 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (29.9 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.9805 mL	29.9025 mL	59.8050 mL	299.0252 mL
5 mM	1.1961 mL	5.9805 mL	11.9610 mL	59.8050 mL
10 mM	0.5981 mL	2.9903 mL	5.9805 mL	29.9025 mL
20 mM	0.2990 mL	1.4951 mL	2.9903 mL	14.9513 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.1196 mL	0.5981 mL	1.1961 mL	5.9805 mL
100 mM	0.0598 mL	0.2990 mL	0.5981 mL	2.9903 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc