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Phenylephrine

Catalog No. T17310   CAS 59-42-7
Synonyms: L-Phenylephrine, (R)-(-)-Phenylephrine

Phenylephrine ((R)-(-)-Phenylephrine) is a selective α1-adrenoceptor agonist ( pKi: 5.86, 4.87 and 4.70 for α1D, α1B, and α1A receptors respectively).

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Phenylephrine Chemical Structure
Phenylephrine, CAS 59-42-7
Pack Size Availability Price/USD Quantity
500 mg In stock $ 42.00
1 mL * 10 mM (in DMSO) In stock $ 46.00
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Purity: 99.92%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Phenylephrine ((R)-(-)-Phenylephrine) is a selective α1-adrenoceptor agonist ( pKi: 5.86, 4.87 and 4.70 for α1D, α1B, and α1A receptors respectively).
Targets&IC50 α1B-adrenergic receptor:4.87 (pKi), α1A-adrenergic receptor:4.70 (pKi), α1D-adrenergic receptor:5.86 (pKi)
In vitro Phenylephrine promotes cardiac fibroblast proliferation. Phenylephrine activates CaN and evokes NFAT3 nuclear translocation. It suggests that the Ca(2+)/CaN/NFAT pathway mediates Phenylephrine-induced cardiac fibroblast proliferation, and this pathway might be a possible therapeutic target in cardiac fibrosis [1][2][3].
In vivo Phenylephrine could enhance the alveolar fluid clearance in high tidal volume-ventilated rats and accelerate the absorption of pulmonary edema. Perfusion of hearts with Phenylephrine (100 μM) induces a rapid (maximal at 10 min) 12-fold activation of two p38-MAPK isoforms. α1-adrenoceptor agonists such as Phenylephrine increase the contractility of the heart. Phenylephrine also activates SAPKs/JNKs in neonatal ventricular myocytes [4][5].
Synonyms L-Phenylephrine, (R)-(-)-Phenylephrine
Molecular Weight 167.21
Formula C9H13NO2
CAS No. 59-42-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 50 mg/mL (245.50 mM), sonification is recommended.

DMSO: 150 mg/mL (736.49 mM)

TargetMolReferences and Literature

1. Ford AP, et al. Pharmacological pleiotropism of the human recombinant alpha1A-adrenoceptor: implications foralpha1-adrenoceptor classification. Br J Pharmacol. 1997 Jul;121(6):1127-35. 2. Minneman KP, et al. Selectivity of agonists for cloned alpha 1-adrenergic receptor subtypes. Mol Pharmacol. 1994 Nov;46(5):929-36. 3. Wang J, et al. Phenylephrine promotes cardiac fibroblast proliferation through calcineurin-NFAT pathway. Front Biosci (Landmark Ed). 2016 Jan 1;21:502-13. 4. Lazou A, et al. Activation of mitogen-activated protein kinases (p38-MAPKs, SAPKs/JNKs and ERKs) by the G-protein-coupled receptor agonist phenylephrine in the perfused rat heart. Biochem J. 1998 Jun 1;332 ( Pt 2):459-65. 5. Li NJ, et al. Effect of phenylephrine on alveolar fluid clearance in ventilator-induced lung injury. Chin Med Sci J. 2013 Mar;28(1):1-6. 6. Chen F, Xu Y, Wang J, et al. Relaxation Effect of Patchouli Alcohol in Rat Corpus Cavernous and Its Underlying Mechanisms[J]. Evidence-Based Complementary and Alternative Medicine. 2020, 2020.

TargetMolCitations

1. Chen F, Xu Y, Wang J, et al. Relaxation Effect of Patchouli Alcohol in Rat Corpus Cavernous and Its Underlying Mechanisms. Evidence-Based Complementary and Alternative Medicine. 2020.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Anti-Neurodegenerative Disease Compound Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Anti-Cancer Compound Library Natural Product Library for HTS Anti-Alzheimer's Disease Compound Library Endocrinology-Hormone Compound Library FDA-Approved Drug Library

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Keywords

Phenylephrine 59-42-7 GPCR/G Protein Neuroscience Adrenergic Receptor inhibit L-Phenylephrine (R)-(-)-Phenylephrine Inhibitor Beta Receptor inhibitor

 

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