Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Phenylephrine ((R)-(-)-Phenylephrine) is a selective α1-adrenoceptor agonist ( pKi: 5.86, 4.87 and 4.70 for α1D, α1B, and α1A receptors respectively).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
500 mg | In stock | $ 42.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 46.00 |
Description | Phenylephrine ((R)-(-)-Phenylephrine) is a selective α1-adrenoceptor agonist ( pKi: 5.86, 4.87 and 4.70 for α1D, α1B, and α1A receptors respectively). |
Targets&IC50 | α1B-adrenergic receptor:4.87 (pKi), α1A-adrenergic receptor:4.70 (pKi), α1D-adrenergic receptor:5.86 (pKi) |
In vitro | Phenylephrine promotes cardiac fibroblast proliferation. Phenylephrine activates CaN and evokes NFAT3 nuclear translocation. It suggests that the Ca(2+)/CaN/NFAT pathway mediates Phenylephrine-induced cardiac fibroblast proliferation, and this pathway might be a possible therapeutic target in cardiac fibrosis [1][2][3]. |
In vivo | Phenylephrine could enhance the alveolar fluid clearance in high tidal volume-ventilated rats and accelerate the absorption of pulmonary edema. Perfusion of hearts with Phenylephrine (100 μM) induces a rapid (maximal at 10 min) 12-fold activation of two p38-MAPK isoforms. α1-adrenoceptor agonists such as Phenylephrine increase the contractility of the heart. Phenylephrine also activates SAPKs/JNKs in neonatal ventricular myocytes [4][5]. |
Synonyms | L-Phenylephrine, (R)-(-)-Phenylephrine |
Molecular Weight | 167.21 |
Formula | C9H13NO2 |
CAS No. | 59-42-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 50 mg/mL (245.50 mM), sonification is recommended.
DMSO: 150 mg/mL (736.49 mM)
You can also refer to dose conversion for different animals. More
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Phenylephrine 59-42-7 GPCR/G Protein Neuroscience Adrenergic Receptor inhibit L-Phenylephrine (R)-(-)-Phenylephrine Inhibitor Beta Receptor inhibitor