Powder: -20°C for 3 years | In solvent: -80°C for 1 year
α1A-AR Degrader 9c is a potent, selective, and reversible PROTAC degrader targeting the α1A adrenergic receptor (α1A-AR) with a DC50 of 2.86 μM. It promotes the proteasomal degradation of the α1A-AR and exhibits anti-proliferative effects against PC-3 cells, presenting an IC50 value of 6.12 μM. This compound demonstrates antitumor activity and holds potential for prostate cancer research [1].
Pack Size | Availability | Price/USD | Quantity |
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5 mg | 35 days | $ 935.00 |
Description | α1A-AR Degrader 9c is a potent, selective, and reversible PROTAC degrader targeting the α1A adrenergic receptor (α1A-AR) with a DC50 of 2.86 μM. It promotes the proteasomal degradation of the α1A-AR and exhibits anti-proliferative effects against PC-3 cells, presenting an IC50 value of 6.12 μM. This compound demonstrates antitumor activity and holds potential for prostate cancer research [1]. |
Targets&IC50 | α1A-adrenergic receptor:2.86 μM (DC50) |
In vivo | Compound 9c, an α1A-AR degrader, at a dose of 50 mg/kg administered intraperitoneally once daily for 15 days, significantly suppresses tumor growth [1]. |
Molecular Weight | 829.82 |
Formula | C38H43N11O11 |
CAS No. | 2863635-02-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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α1A-AR Degrader 9c 2863635-02-1 PROTAC PROTACs inhibitor inhibit