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Silodosin

Name: Silodosin
Brand: TargetMol
SKU: T1504
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1504Cas No. 160970-54-7

Alias KMD 3213, KAD 3213

Silodosin (KAD 3213) is an alpha-Adrenergic Blocker. The mechanism of action of silodosin is as an Adrenergic alpha-Antagonist.

Silodosin

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Purity: 99.76%

Catalog No. T1504Alias KMD 3213, KAD 3213Cas No. 160970-54-7

Silodosin (KAD 3213) is an alpha-Adrenergic Blocker. The mechanism of action of silodosin is as an Adrenergic alpha-Antagonist.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$30	In Stock	In Stock
10 mg	$48	In Stock	In Stock
25 mg	$71	In Stock	In Stock
50 mg	$88	In Stock	In Stock
100 mg	$106	In Stock	In Stock
200 mg	$135	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$32	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.76%

Color:White

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COA

Product Introduction

Bioactivity

Description	Silodosin (KAD 3213) is an alpha-Adrenergic Blocker. The mechanism of action of silodosin is as an Adrenergic alpha-Antagonist.
Targets&IC50	α1D-adrenoceptor:2 nM (Ki), α1B-adrenoceptor:21 nM (Ki), α1A-adrenoceptor:0.036 nM (Ki)
In vitro	Silodosin (0.1-0.3 mg/kg) significantly reduces intralumenal ureteral pressure by 21-37% in obstruction-induced scenarios, whereas Phentolamine (0.03-0.1 mg/kg) can increase it by 18-40%. In dogs with benign prostatic hyperplasia, Silodosin (0.3-300 mg/kg) dose-dependently inhibits the increase in urethral pressure induced by pelvic nerve stimulation without notable hypotensive effects. In rabbit lower urinary tract tissues, Silodosin markedly antagonizes contractions induced by norepinephrine (including in the prostate, urethra, and bladder trigone, with PA(2) or pKb values of 9.60, 8.71, and 9.35, respectively). Oral administration of Silodosin in rats significantly inhibits the increase in urethral pressure caused by phenylephrine at 12 h, 18 h, and 24 h post-administration compared to the control group. Silodosin exhibits inhibitory effects on isolated contractions of rat and human ureters and possesses strong functional selectivity for relieving pressure in ureteral obstruction in rats.
In vivo	Silodosin and tadalafil synergistically inhibit neurally-mediated contraction effects in human and rat ex vivo prostates. Compared to tamsulosin hydrochloride, naftopidil, or prazosin hydrochloride, Silodosin exhibits higher selectivity for the α(1A)-AR subtype, with the affinity order being highest for tamsulosin hydrochloride, followed by Silodosin, prazosin hydrochloride, or naftopidil.
Synonyms	KMD 3213, KAD 3213

Chemical Properties

Molecular Weight	495.53
Formula	C₂₅H₃₂F₃N₃O₄
Cas No.	160970-54-7
Smiles	C(CCO)N1C=2C(=CC(C[C@H](NCCOC3=C(OCC(F)(F)F)C=CC=C3)C)=CC2C(N)=O)CC1
Relative Density.	1.249 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store under nitrogen | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 92 mg/mL (185.66 mM), Sonication is recommended.

Ethanol: 92 mg/mL (185.66 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.66 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.0180 mL	10.0902 mL	20.1804 mL	100.9021 mL
5 mM	0.4036 mL	2.0180 mL	4.0361 mL	20.1804 mL
10 mM	0.2018 mL	1.0090 mL	2.0180 mL	10.0902 mL
20 mM	0.1009 mL	0.5045 mL	1.0090 mL	5.0451 mL
50 mM	0.0404 mL	0.2018 mL	0.4036 mL	2.0180 mL
100 mM	0.0202 mL	0.1009 mL	0.2018 mL	1.0090 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc